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Stefano Cianfarani
Curriculum Vitae et Studiorum
e
Pubblicazioni
del
Prof. Stefano Cianfarani
19.6.2024
“… Noi non cerchiamo quello che Iddio poteva fare, ma quello che Egli ha fatto…poi finalmente sollevandoci all’ultimo scopo delle nostre fatiche, cioè all’amore del Divino Artefice, ci conservino la speranza di poter apprendere in Lui, fonte di luce e di verità ogni altro vero.” (Galileo Galilei)
Stefano Cianfarani
Nome: Stefano Cianfarani
Indirizzo Università: Clinica Pediatrica-Dipartimento di Medicina dei Sistemi, Università degli Studi di Roma “Tor Vergata”, Via Montpellier 1, 00133-Roma
Tel: 06-6859 3074 (Osp.)
Tel: 06-7259 6178 (Lab.)
Fax: 06-6859 2508
Indirizzo casa: Via Città di Castello 35,
00191 - Roma
Tel: 06- 33 30 813
E-Mail: stefano.cianfarani@uniroma2.it
Codice Fiscale: CNFSFN57T20H501C
Data di nascita: 20 Dicembre 1957
Luogo di nascita: Roma
Nazionalità: Italiana
Stato Civile: Sposato con Teresa Maria Martino. Padre di Francesco, Eugenia, Agnese, Bernardo, Bartolomeo e Giovanni Maria
Scolarità: Diploma di Maturità (60/60) presso il Liceo Classico della Scuola Pontificia Scuola "Pio IX" nel 1976.
Facoltà di Medicina
e Chirurgia: Universita' degli Studi di Roma
"La Sapienza" 1976-1982.
Voto di Laurea 110/110 con Lode
Scuola di
Specializzazione: Pediatria, Universita' degli Studi
di Roma "La Sapienza" 1982-1986.
Voto diploma di Specializzazione 70/70 con Lode.
Attuale posizione : Professore Ordinario di Pediatria Generale e Specialistica (MED/38). Dipartimento Medicina dei Sistemi, Facoltà di Medicina e Chirurgia dell’Università di Roma Tor Vergata, Roma.
Responsabile della Unità Operativa Complessa (U.O.C.) di “Endocrinologia e Diabetologia”, presso Ospedale Pediatrico I.R.C.C.S. Bambino Gesù, Roma.
Dal 1/11/2012 Visiting Professor presso il Department of Women´s and Children´s Health, al Karolinska Institute, Stoccolma, Svezia.
Attualmente: Affiliated Researcher presso il Department of Women´s and Children´s Health, al Karolinska Institute, Stoccolma, Svezia.
Referente dell’Unità di Ricerca “Fisiopatologia della Crescita”, Ospedale Pediatrico “Bambino Gesù”, Roma.
Chair of Clinical Practice Committee della European Society fo Pediatric Endocrinology (ESPE), 2022-2025.
Posizioni Precedenti: Professore Associato di Pediatria Generale e Specialistica (MED/38), Facoltà di Medicina e Chirurgia, Università degli Studi di Roma Tor Vergata.
Dal 1.11.2002 al 27/2/2018
Responsabile della Unità Operativa Complessa (U.O.C.) di “Diabetologia e Patologia dell’Accrescimento”, presso Ospedale Pediatrico I.R.C.C.S. Bambino Gesù, Roma.
Dal 2017 al 2018 Responsabile della Struttura Semplice Dipartimentale di “Diabetologia”, presso Ospedale Pediatrico I.R.C.C.S. Bambino Gesù, Roma.
Dal 1/10/2009 al 15/5/2017 Responsabile Struttura Semplice di “Endocrinologia Molecolare” presso Ospedale Pediatrico I.R.C.C.S. Bambino Gesù, Roma.
Dal 1/7/1988, Funzionario Tecnico, Clinica Pediatrica, Dipartimento di Sanità Pubblica e Biologia Cellulare, Università degli Studi di Roma, "Tor Vergata", Roma.
Dal 25/11/1988, Dirigente I livello (Assistente Ospedaliero) presso la Divisione di Pediatria, Ospedale S. Eugenio, Azienda USL RM-C, Roma.
Dal 24/3/2003 Dirigente I Livello (ex Aiuto Ospedaliero) presso la Divisione di Pediatria (U. Org. Patologi Endocrina Pediatrica), Ospedale S. Eugenio, Azienda USL RM-C, Roma.
Dal 1995, Responsabile del Laboratorio di Endocrinologia Pediatrica, Università “Tor Vergata”, Roma
Dal 24/03/2003 al 30/09/2009 Responsabile dell’Unità Organizzativa di Patologia Endocrina Pediatrica, Ospedale S.Eugenio, ASL RM-C, Roma.
Dal 1/1/2009 al 31/8/2009 incaricato dal Rettore dell’Università di Roma “Tor Vergata” come Direttore della Clinica Pediatrica dell’Università di Roma “Tor Vergata” con sede presso l’Ospedale S.Eugenio Roma.
Presidente Società Italiana di Endocrinologia e Diabetologia Pediatrica (SIEDP) per il biennio 2017-2019.
Presidente European Society fo Pediatric Endocrinology (ESPE) 2022.
Tipologia Prestazioni
Assistenziali: -Dalla data di strutturazione (1988):Assistenza diurna, notturna e festiva presso U.O.C. di Pediatria presso Ospedale S. Eugenio Roma, ASL-RMC, in convenzione con Università degli Studi di Roma Tor Vergata, con compiti di responsabilità diretta, con turni periodici di corresponsabilità del Reparto. Consulenze diurne, notturne e festive presso la Accettazione e il Pronto Soccorso dell’Ospedale S. Eugenio, Azienda USL RM-C, Roma, con compiti di responsabilità diretta.
-Delegato periodicamente dal Primario della U.O.C. di Pediatria a sostituirlo come responsabile della stessa U.O.C. di Pediatria presso Ospedale S. Eugenio Roma, ASL-RMC, in convenzione con Università degli Studi di Roma Tor Vergata.
-Attività ambulatoriale specialistica in Patologia Endocrina Pediatrica e responsabile della Unità Organizzativa di Patologia Endocrina Pediatrica-B2 su delibera del Consiglio di Facoltà del 24/10/2002 ed in conformità con quanto stabilito dalla ASL RMC in data 23/1/2002 delibera n. 42.
-Incaricato dal Rettore dell’Università di Roma Tor Vergata ad esercitare funzione primariale temporanea presso la U.O.C. di Pediatria-Oncoematologia Pediatrica presso l’Ospedale S. Eugenio dal decorrenza dal 1.12.2008.
Attività Didattica Insegnamenti: Corso di Laurea in Medicina
2002-2012 Corso Integrato di Pediatria (Scienze Pediatriche)
Scuola di Specializzazione in Pediatria:
1989-1991 Clinica Pediatrica
1991-1993 Pediatria Generale e Specialistica
1993-1996 Endocrinologia
1999-2000 Pediatria Generale
2001-2004 Endocrinologia Pediatrica e Malattie del Metabolismo Infantile e Neonatale
2002-2003 Patologia Clinica
2003-2006 Endocrinologia Pediatrica
2004-2005 Pediatria Generale e Specialistica
2007-2012 Pediatria Generale e Specialistica
Scuola di Specializzazione Scienze dell’Alimentazione:
2000/2001, 2003/2004, 2005-2008 Pediatria
Scuola di Specializzazione in Neuropsichiatria Infantile
2005-2008 Neuropsicoendocrinologia
Scuola di Specializzazione in Ortopedia e Traumatologia 2009 PediatrIa
Diploma Universitario in Dietologia e Dietetica Applicata
1995-1997 Patologia dell’età evolutiva
Diploma Universitario in Dietista
1997-2001 Patologia dell’età evolutiva
Diploma Universitario in Ostetricia
1997-1998 Cardiologia Pediatrica
Diploma Universitario Tecnici in Riabilitazione Psichiatria
2010 Pediatria
Dottorato di Ricerca in Pediatria Molecolare,
Università Tor Vergata, Roma.
Docente AA.AA. 2002-2006.
Scuola di Alta Formazione in Pediatria, Università Tor Vergata/Ospedale Pediatrico Bambino Gesù, Roma.
2012 Comitato Scientifico
Master in Endocrinologia Pediatrica, Università di Parma
AA 2010 e 2012 Basse stature da alterazione periferica
Docente e organizzatore Corso di Perfezionamento in Endocrinologia Pediatrica, Università Tor Vergata, Roma, 10/3-9/6, 1999-2000.
Docente e coordinatore Corso di Perfezionamento in Endocrinologia Pediatrica, Università Tor Vergata, Roma, 2000-2001.
Docente Winter School, European Society for Paediatric Endocrinology, Varna, Bulgaria, 4-11 marzo 2006.
Master Direttore Master II livello in Endocrinologia e Diabetologia Pediatrica, Scuola di Alta Fromazione in Pediatria, Università degli Studi di Roma Tor Vergata e Ospedale Pediatrico Bambino gesù, Roma. Primo ciclo a partire dal 2014.
PhD courses
(Dottorato di ricerca) Docente del Corso di Dottorato in Pediatria Molecolare Università degli Studi di Roma Tor Vergata (2003-2004).
Docente del Corso di Dottorato in Pediatria Molecolare e Biotecnologie Applicate, Università degli Studi di Roma Tor Vergata (2005).
Docente del Corso di Dottorato in "Immunologia, medicina molecolare e biotecnologie applicate ( ex immunologia e biotecnologie applicate)"Università degli Studi di Roma Tor Vergata (2012-2016).
Docente del Corso di Dottorato in "Immunologia, medicina molecolare e biotecnologie applicate ( ex immunologia e biotecnologie applicate)"Università degli Studi di Roma Tor Vergata (2012-2017).
Tutor and Supervisor:
Supervisore della Dr.ssa Caterina Geremia, PhD, with the Thesis: “Metabolic programming in intrauterine groath retardsation (IUGR). Results from clinical and laboratory investigations”. Tor Vergata University, Rome, 2007.
Supervisore della Dr.ssa Arianna Maiorana, PhD, with the Thesis: “A Method to Isolate Omental Adipose Stem cells in Pediatric Patients: Perspectives in investigating the Pathogenesis of metabolic Syndrome”. Tor Vergata University, Rome, 2008
Official opponent in doctoral dissertation of PhD. Candidate Sirpa Tenhola, Thesis Title: Cardiovascular Risk Factors and Adrenal Function in 12-year-old Children Born Small for Gestational age or After a Preeclamptic Pregnancy, University of Kuopio, Finland, 2006.
Supervisore della Dr.ssa Valentina Pampanini, PhD Course, Women's and Children's Health, Pediatric Endocrinology Unit, Karolinska Institute, Stoccolma Sweden.
Official opponent in doctoral dissertation of PhD. Candidate Manouk van der Steen, Thesis Title: Growth hormone treatment in SGA. More than meet the eye. Erasmus University, Rotterdam, 2016.
Official opponent in doctoral dissertation of PhD. Candidate Carolina Smeets, Thesis Title:
“Silver-Russell Syndrome & Small for Gestational Age
Long-term health perspectives” Erasmus University, Rotterdam, 2017.
External reviewer in doctoral dissertation of PhD. Candidate Nicola Improda, Thesis title:
“New insights in childhood-onset growth hormone deficiency: from diagnosis to long-term outcomes”. Clinical and Experimental Medicine, University of Naples Federico II, Naples, 2021.
Official opponent in doctoral dissertation of PhD. Candidate Wesley J. Goedegebuure, Thesis Title:
“Small for gestational age. Adult metabolic and cardiovascular health and long-term safety of growth hormone treatment”. Erasmus University, Rotterdam, 2021.
Società
di appartenenza: Ordine dei Medici della Provincia di Roma
N. 32942 (10/2/1983)
British General Medical Council
Registration N. 3417762 (13/5/1991)
· Società Italiana di Pediatria
· Società Italiana di Endocrinologia e Diabetologia Pediatrica
· European Society for Pediatric Endocrinology (ESPE)
Incarichi Internazionali Chairman of the Clinical Practice Committee della European Society for Pediatric Endocrinology dal 2004 al 2010.
Comitato scientifico della Consensus Conference internazionale sull’approccio diagnostico e terapeutic del bambino nato piccolo per età gestazionale. Un Simposio internazionale organizzato congiuntamente dalla European Society for Pediatric Endocrinology (ESPE), Lawson Wilkins Society for Pediatric Endocrinology (LWPES) and la Growth Hormone Research Society (GRS). Manchester, UK, 2006
Membro del Consiglio Direttivo della European
Society for Pediatric Endocrinology 2004-2010.
Membro del Programme Organizing Committee della European Society for Pediatric Endocrinology 2004-2010.
Consulente temporaneo Organizzazione Mondiale della Sanità (OMS). 2006.
Membro temporaneo dell’EMA Scientific Advisory Group (SAG) for Diabetes/Endocrinology dal 2007.
Membro Advisory Group della ERA-NET PRIOMEDCHILD European Network for Medicines in Childhood. 2008.
Comitato scientifico organizzatore della Consensus Conference internazionale Growth Hormone Safety Workshop Workshop internazionale organizzato congiuntamente dalla European Society for Pediatric Endocrinology (ESPE), Pediatric Endocrinology Society (PES) and Growth Hormone Research Society (GRS). Manchester, UK, November, 2014.
Chair of the Board of Advanced Seminars in Developmental Endocrinology (2014-2016), European Society for Pediatric Endocrinology (ESPE)
Dal 2015 al 2019, membro del pannello di esperti del Science Committee della European Society for Pediatric Endocrinology (ESPE).
Premi Internazionali Nomination per il Research Award della European Society for Pediatric Endocrinology (2005, 2006, 2007).
Comitati e Consulenze
Scientifiche: Comitato scientifico, V Congresso della Società Italiana di Endocrinologia e Diabetologia Pediatrica (SIEDP). Roma 18- 19 Ottobre 1985.
Scientific Secretary, International Workshop on Binding Proteins for Growth Hormone and Somatomedins, Roma, November 23-24, 1990.
Consulente scientifico per la R.A.I. per trasmissioni sulla crescita e la pubertà (D.S.E.) 1985 e 1986.
Comitato Scientifico, Corso SIEDP in Endocrinologia Pediatrica, Sabaudia 5-7 Ottobre 2000.
Coordinatore Corso di Perfezionamento in Endocrinologia Pediatrica, Università di Tor Vergata, Roma, 2002.
Coordinatore Gruppo di Studio su “Fisiopatologia dei processi di accrescimento” Società Italiana di Endocrinologia e Diabetologia Pediatrica (SIEDP), 2001-2003
Comitato scientifico dell’Accademia Nazionale di Medicina, coordinatore per il settore Endocrinologia e Malattie del Ricambio dell’Età Evolutiva (2005-2008).
Responsabile commissione giovani Società Italiana di Endocrinologia e Diabetologia Pediatrica (SIEDP) 2007-2009
Responsabile commissione farmaci Società Italiana di Medicina dell’Adolescenza (SIMA) 2009-2011.
Membro Comitato Scientifico Fondazione “Cesare Serono”, dal 2011.
Membro Gruppo di Lavoro Ricerca e Sviluppo, Agenzia Italiana del Farmaco (AIFA) 2011-2012.
Member of the Steering Committee, European Society for Pediatric Endocrinology (ESPE) Advanced Seminar in Developmental Endocrinology (From 2012).
Borse di Studio: C.N.R. borsa di studio per l'estero (n.203.04.10 6/5/1986) per il progetto: "Western Blotting Technique in the study of short stature" (1986). Department of Chemical Endocrinology, St. Bartholomew's Hospital, Londra, Gran Bretagna
C.N.R.-N.A.T.O. junior fellowship (n. 215.24 18/01/90) per il progetto: "Insulin-like growth factor binding proteins in children with short stature" (1990). Division of Pediatric Endocrinology, St. Bartholomew's Hospital, Londra, Gran Bretagna.
C.N.R.-N.A.T.O. senior fellowship (n. 217.28 del 29/4/1995) per il progetto: "Effetto dell’ormone della crescita e dei fattori di crescita insulino-simili (IGFs) sulla stabilità del genoma umano: studio “in vitro” e “in vivo”. University of Bristol, Bristol, Gran Bretagna.
Precedenti Posizioni scientifiche e
professionali all’estero: Visiting Paediatrician, Department of Growth and Development, (Prof. J.M. Tanner) Institute of Child Health, University of London, U.K. Settembre 1984
Visiting Researcher, Laboratory of Tumor Cell Biology, (Dr. R.C. Gallo), National Institutes of Health, National Cancer Institute, Bethesda, Maryland, U.S.A.
Da Agosto a Settembre 1985
Research Fellow in Endocrinology (Prof. L.H. Rees), Department of Chemical Endocrinology, St. Bartholomew's Hospital, London U.K.
Da Settembre 1988 a Febbraio 1989
Research Fellow in Paediatric Endocrinology, Division of Paediatric Endocrinology, Department of Endocrinology, St. Bartholomew's Hospital, London EC1A 7BE
Da Maggio 1991 ad Aprile 1992
Honorary Clinical Assistant in Paediatric Endocrinology, Department of Paediatric Endocrinology, Dr. Martin Savage, "The Queen Elizabeth Hospital for Children", London, E2 8PS
Da Maggio 1991 ad Aprile 1992
Teacher of Endocrinology of Growth, Serono, Auxology Course, St. Bartholomew's Hospital, London EC1A 7BE. 1991-1992
Honorary Research Fellow in Pediatric Endocrinology,
Royal Hospital for Sick Children, Bristol BS2 8BJ, dal 28 Ottobre 1996 per 2 anni.
Visiting Fellow in Surgery,
Bristol Royal Infirmary, University of Bristol, Bristol BS2 8BJ, U.K. dal 30 Novembre 1996 per due anni.
Organizzazione Conferenze
Internazionali: Organizer and member of the Steering Committee. International Conference Organization Workshop on Binding Proteins for Growth Hormone and Somatomedins. Rome, November 23-24, 1990. Organizer and member of the Steering Committee.
IGF-I and IGF binding protein assessment and therapeutic benefit. Serono Symposia, New Orleans, June 14-15, 2004.
Organizer and member of the Steering Committee.
ESPE/GRS/LWPES Consensus Workshop on Management of the Small for Gestational Age Child.
1-4 February 2006 Manchester, UK
Delegate to
ESPE/GRS/LWPES Consensus Workshop on Idiopathic Short Stature.
17-20 October 2007, Los Angeles, CA, US
Comitato scientifico organizzatore della Consensus Conference internazionale Growth Hormone Safety Workshop Workshop internazionale organizzato congiuntamente dalla European Society for Pediatric Endocrinology (ESPE), Pediatric Endocrinology Society (PES) and Growth Hormone Research Society (GRS). Manchester, UK, November, 2014.
Editorial Board 1. Editor in Chief, Frontiers in Pediatric Endocrinology, Frontiers Research Foundation, Lausanne, Switzerland, fino a Gennaio 2014
2. Associate Editor of Review of Diabetic Studies, Society for Biomedical Diabetes Research. Fino a Gennaio 2014.
3. Editor in Chief (appointed from 2014), Hormone Research in Paediatrics, Karger, Basel, Switzerland.
4. Advisory Board member of Biomedicine Hub, Karger, Basel, Switzerland. Dal 2016
5. Editorial board: Annals of Pediatric Endocrinology and Metabolism, dal 2016.
6. Editorial board: Jornal de Pediatria, Brazil, dal 2021
Incarichi Accademici
Internazionali Official opponent in doctoral dissertation of PhD. Candidate Sirpa Tenhola, Thesis Title: Cardiovascular Risk Factors and Adrenal Function in 12-year-old Children Born Small for Gestational age or After a Preeclamptic Pregnancy, University of Kuopio, Finland, May 27th, 2006.
Teacher of Evidence-Based Medicine in Paediatric Endocrinology, at the “Advanced Postgraduate Course on Methods in Growth Research – Theory and Practice”. Karolinska Institutet, Stockholm, November 22-26, 2010.
Supervisore della Dr.ssa Valentina Pampanini, PhD Course, Women's and Children's Health, Pediatric Endocrinology Unit, Karolinska Institute, Stoccolma Sweden.
Official opponent in doctoral dissertation of PhD. Candidate Manouk van der Steen, Thesis Title: Growth hormone treatment in SGA. More than meet the eye. Erasmus University, Rotterdam, 2016.
Reviewer per:
- Acta Paediatrica
- Acta Obstetrica and Gynaecologica Scandinavica
- Americal Journal of Clinical Nutrition
- Archives for Diseases in Childhood
- BMC Medical Genetics
- Clinical Endocrinology
- Diabetes
- Diabetologia
- Dutch Diabetes Research Foundation
- Endocrinology
- European Society for Pediatric Endocrinology
- European Journal of Endocrinology
- Frontiers in Pediatric Endocrinology
- Hormone Research
- International Journal of Cancer
- International Journal of Clinical Practice
- International Journal of Obesity
- Italian Ministry of University and Research (MIUR). National Research Programmes (PRIN).
- Journal of Clinical Endocrinology and Metabolism
- Journal of Endocrinological Investigation
- Journal of Pediatric Endocrinology and Metabolism
- Journal of Pediatrics
- Lancet
- Metabolism
- Obesity
- Pediatric Research
- Pediatrics
- Psychoneuroendocrinology
- Review of Diabetic Studies
- Swiss National Science Foundation
- Trends in Endocrinology and Metabolism
- European Commission – HORIZON 2020
Direzione Attività Formativa ECM Responsabile Evento Formativo Tavola Rotonda: Prevenzione dell’Osteoporosi dell’Adulto in Età Pediatrica. Roma 6-9.2003. Crediti ECM assegnati: n. 3
Responsabile Evento Formativo Corso di Aggiornamento: Errori in Endocrinologia Pediatrica. Roma 18-10.2003. Crediti ECM assegnati: n. 6
Responsabile Evento Formativo:
Corso di Aggiornamento in Endocrinologia Pediatrica, “Terapia Endocrina nell’Età Evolutiva”.
Roma, Marzo-Giugno, 2004. Crediti ECM assegnati: n. 23
Responsabile Evento Formativo con US CME:
“IGF-I and IGF binding protein assessment and therapeutic benefit”. New Orleans 14-15 Giugno, 2004, Serono Symposia.
Responsabile Evento Formativo:
Corso di Aggiornamento in Endocrinologia Pediatrica, “Endocrinologia pediatrica per problemi”.
Roma, Marzo-Giugno, 2006. Crediti ECM assegnati: n. 17
Responsabile evento formativo: Corso di Aggiornamento in Endocrinologia Pediatrica, “Clinical Practice in Endocrinologia Pediatrica” Roma, Marzo-Giugno, 2008. crediti ECM: 19
Responsabile evento formativo: Corso di aggiornamento, “SGA: cause e conseguenze del basso peso alla nascita”. Roma, 21 Giugno, 2008. crediti ECM: 6
Attività formativa Coordinatore del Corso di Endocrinologia Pediatrica,
per paesi in via di sviluppo per conto della Società Europea di Endocrinologia Pediatrica (ESPE). Nairobi (Kenia) 16-20 Maggio, 2006.
Research Grants Gestiti
come Responsabile “The Prevention of osteoporosis by nutrional phytoestrogens (PHYTOS)”. Shared Cost RTD actions. European Commission. Anno 1999, durata 48 mesi, Proposal No. QLRT-1999-00857. Subcontractor of Contractor 1: Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione. “Deteminazione di IGF-I, IGFBP-3, IGFBP-4 e forme circolanti di IGFBP-3”.
Importo finanziato pari a 45.000 EURO. Principal Investigator and Coordinator
“Terapia sperimentale nell’adrenoleucodistrofia”.
Fondazione Baroni. Anno 2000-2001.
Importo finanziato pari a Lire 50.000.000
“Phytohealth”. European Network for Research on Phytoestrogens. CORDIS RTD-Project #68987, EC 2003; 5000 EURO
“S6 Kinase activity in Human Placentas from Normal and SGA Fetuses”. MIUR 60% 2003. 2500 EURO. Principal Investigator and Coordinator
“Origine fetale delle malattie dell’adulto. Identificazione precoce dei fattori di rischio cardiovascolare e metabolico nei soggetti nati con ritardo di crescita ad inizio intrauterino”. MIUR COFIN-40% - 2003 . Coordinatore Nazionale del Progetto. Euro: 136.000. Responsabile Unità Operativa, Roma, Tor Vergata, EURO 63.000. Principal Investigator and Coordinator
“Proteolisi della IGFBP-3 nei pazienti con deficit di GH (GHD). Effetto sulla sensibilità e specificità del dosaggio della IGFBP-3 nella diagnosi di GHD.” Progetti di Ricerca di Ateneo (ex 60%). Anno 2005. EURO 4.200. Principal Investigator and Coordinator
Riprogrammazione dell’attività S6K e IRS-1 ed espressione dei recettori per insulina e IGF-I nei bambini small for gestational age (SGA). Progetti di Ricerca di Ateneo (ex 60%). Anno 2006. EURO 2.300. Principal Investigator and Coordinator
“SAGhE: Safety and Appropriateness of
Growth hormone treatments in Europe”. FP7-HEALTH-2007: Better use of medicines
Collaborative projects (Small or medium-scale focused research projects)
Coordinating person: Jean-Claude Carel
EU grant FP7-223497, 2009-2012. Euro 440000 for the local Unit (Tor Vergata, University, Rome) coordinated by Prof. Stefano Cianfarani, Principal Investigator and Coordinator of WORKPACKAGE 4.
“Protective role of IGF-I in premature babies at risk of neurological damage and retinopathy” Eli Lilly grant 2009. euro 70.000. Pricipal Investigator and Coordinator
“Metilazione del gene igf2, ritardo di crescita ad inizio intrauterino e alterazioni metaboliche. Studio clinico in bambini obesi nati piccoli per età gestazionale e con peso alla nascita appropriato per età gestazionale.” Ricerca Corrente Ospedale Pediatrico Bambino Gesù, IRCCS, 2011. 12.000 Euro. Principal Investigator and Coordinator
“Growth Hormone Treatment For Short Children Born Preterm And Presenting Extrauterine Growth Retardation”. Principal Investigator and Coordinator.
Pfizer grant 2011. 164.000 Euro
“Studio multicentrico europeo sulla identificazione dei fattori di rischio metabolico in bambini ed adolescenti obesi.” Ricerca Corrente Ospedale Pediatrico Bambino Gesù, IRCCS, 2012. 60.000 Euro. Principal Investigator and Coordinator
Deficit Subclinico di Vitamina D e Rischio Metabolico e Cardiovascolare in Bambini Obesi. Trial Pilota Randomizzato Controllato con Vitamina D3. Ricerca Corrente Ospedale Pediatrico Bambino Gesù, IRCCS, 2013. 52000 Euro. Principal Investigator and Coordinator.
miRNA – Novel markers to predict the development of obesity‐related disorders?
Collaborative International Project. European Society for Paediatric Endocrinology-Research Unit. Co- Investigator. 2013. 60000 Euro.
"PERSUADED. Phthalates and bisphenol : a biomonitoring in Italian mother-child pairs: link between exposure and juvenile diseases" LIFE13 ENV/IT/000482. Principal Investigator of “Bambino Gesù” Children’s Hospital Unit.
Progetto cofinanziato Comunità Europea. Cofinanziamento richiesto 877658 Euro
Principal Investigator of “Bambino Gesù” Children’s Hospital Unit. 238.853 Euro.
Translational approaches to disease modifying therapy of type 1 diabetes - HARVESTing the fruits of INNODIA
European Commission (BRUSSELS )
2020-06 to 2023-06|Grant GRANT_NUMBER: 945268
Translational approaches to disease modifying therapy of type 1 diabetes: an innovative approach towards understanding and arresting type 1 diabetes - Sofia ref.: 11579 European Commission (Brussels) 2015-11-01 to 2022-10-31|Gran GRANT_NUMBER: 11579 URL:https://app.dimensions.ai/details/grant/grant.6814282
TESI
Tesi di Laurea in Medicina e Chirurgia: "Patologia pediatrica da difetti recettoriali", 1982, Relatore Prof. B. Boscherini.
Tesi di Diploma per la Specializzazione in Pediatria: "Nuovi metodi di indagine della funzionalità somatotropinica", 1986, Relatore Prof. B. Boscherini.
PUBBLICAZIONI
ORIGINAL ARTICLES
1. Spadoni G.L., Cianfarani S., Boscherini B.
Le Somatomedine.
Rivista Italiana di Pediatria 10, 347-351, 1984.
2. de Capoa A., Baldini A., Marlekaj P., Natoli C., Rocchi M.,
Archidiacono N., Cianfarani S., Spadoni G.L., Boscherini B.
Hormone-modulated rRNA gene activity is visualized by
selective silver staining of the NOs.
Cell Biology International Reports 9, 791-796, 1985
3. de Capoa, Marlekaj P., Baldini A., Felli M.P., Rocchi M.,
Archidiacono N., Cianfarani S., Spadoni G.L., Boscherini B.
Growth-hormone induced regulation of rRNA gene activity in
human cultured cells.
Hormone and Metabolic Research 18, 574-575, 1986.
4. Cianfarani S., Spadoni G.L., Finocchi G., Ravet P., Costa
F., Papa M., Scirè G., Manca Bitti M.L., Boscherini B.
Growth hormone treatment in Noonan's syndrome.
Minerva Pediatrica 39, 281-284, 1987.
5. Cianfarani S., Spadoni G.L., Scirè G., Galasso C., Benvenuti
S., Manca Bitti M.L., Rezza E., Boscherini B. Pretreatment
growth velocity and response to GH (HGH) therapy.
Minerva Pediatrica 39, 757-761, 1987.
6. Vaccaro F., Cioschi S., Falvo F., Bernardini S., Spadoni
G.L., Cianfarani S., Carrozzo A.M., Nini G., Galasso C.,
Manca Bitti M.L., Pasquino A.M.
Acanthosis Nigricans, insulino-resistenza ed endocrinopatie: attuali vedute e conoscenze.
Il Progresso Medico 43, 483-489, 1987.
7. Spadoni G.L., Cianfarani S., Baldini A., Ravenna L., Felli
M.P., Camaioni A., Manca Bitti M.L., Scirè G., Boscherini B., de Capoa A.
Laron dwarfism: cellular unresponsiveness to GH demonstrated on cultured lymphocytes by a cytochemical method.
Hormone and Metabolic Research, 20, 450-452, 1988.
8. Boscherini B., Cianfarani S., Spadoni G.L.
Growth Disorders.
Medicina 8, 287-292, 1988.
9. Baldini A., Felli M.P., Ravenna L., Camaioni A., de Capoa
A., Spadoni G.L., Cianfarani S., Boscherini B.
Differential ribosomal gene responsiveness to human growth hormone is
visualized by selective silver staining.
Cytogenetics and Cell Genetics 47, 22-25, 1988.
10. Spadoni G.L., Cianfarani S., Bernardini S., Vaccaro F.,
Galasso C., Manca Bitti M.L., Costa F., Boscherini B.
Twelve-hour spontaneous nocturnal growth hormone secretion
in growth retarded patients.
Clinical Pediatrics 27, 473-478, 1988.
11. Holly JMP, Smith CP, Dunger DB, Howell RJS, Chard T, Perry
LA, Savage MO, Cianfarani S., Rees LH, Wass JAH.
Relationship between the pubertal fall in sex hormone-
binding globulin and insulin-like growth factor binding
protein-I. A synchronised approach to pubertal development?
Clinical Endocrinology 31, 277-284, 1989.
12. Bernardini S., Cianfarani S., Galasso C., Spagnoli A.,
Vaccaro F., Spadoni G.L.
Somatotropin function in Noonan's syndrome.
Pediatria Oggi 9, 110-112, 1989.
13. Spagnoli A., Bernardini S., Galasso C., Vaccaro F., Manca
Bitti M.L., Scirè G., Cianfarani S., Spadoni G.L.
Treatment of somatotropic deficiency with biosynthetic growth hormone.
Medical and Surgical Pediatrics 11, 5-10, 1989.
14. Cianfarani S., Holly JMP
Somatomedin-binding proteins: what role do they play in the growth process?
European Journal of Pediatrics 149:76-79, 1989.
15. Spadoni G.L., Cianfarani S., Bernardini S., Vaccaro F.,
Galasso C., Boscherini B.
Growth hormone treatment in children with sporadic primary microcephaly.
American Journal of Diseases in Childhood 143, 1282-1283, 1989.
16. Boscherini B., Cianfarani S., Spadoni G.L.
Clinical features of growth hormone (GH) deficiency.
Journal of Endocrinological Investigation 12, 17-19, 1989.
17. Holly JMP, Edeb JA, Alaghband-Zadeh J, Carter GD, Jemmott
RC, Cianfarani S., Chard T, Wass JAH.
Insulin-like growth factor binding proteins in follicular fluid from normal
dominant and cohort follicles, polycystic and multicystic ovaries.
Clinical Endocrinology 33, 53-64, 1990.
18. Vaccaro F, Cianfarani S., Spadoni GL, Spagnoli A, Bernardini
S, Galasso C, Boscherini B.
Growth hormone therapy in non GH-deficient short children.
Rivista Italiana di Pediatria 16, 528-534, 1990.
19. Spadoni GL, Spagnoli A, Cianfarani S., Del Principe D,
Menichelli A, Di Giulio S, Boscherini B.
Enhancement of phorbol diester-stimulated respiratory burst in human
polymorphonuclear leukocytes by growth hormone.
Acta Endocrinologica (ora European Journal of Endocrinology) 124, 589-594, 1991.
20. Spadoni G.L., Rossi P., Ragno W., Galli E., Cianfarani S.,
Galasso C., Boscherini B.
Immune function in growth hormone deficient children treated with biosynthetic growth hormone.
Acta Paediatrica Scandinavica 80, 75-79, 1991.
21. Cianfarani S., Vaccaro F, Spadoni GL, Galasso C, Bernardini
S, Spagnoli A, Boscherini B.
Abnormal growth velocity does not impair the attainment of target height in "small-delay" children.
Acta Medica Auxologica 23, 245-251, 1991.
22. Bernardini S, Spadoni GL, Cianfarani S, Scalera G, Cives C,
Vaccaro F, Pasquino AM, Boscherini B.
Growth hormone response to growth hormone releasing factor in Turner's syndrome.
Acta Medica Auxologica 23, 173-178, 1991.
23. Bernardini S, Spadoni GL, Cianfarani S, Vaccaro F, Pasquino
AM, Boscherini B.
Growth hormone secretion in Noonan's syndrome.
Journal of Pediatric Endocrinology (now Journal of Pediatric Endocrinology and Metabolism) 4, 217-221, 1991.
24. Cianfarani S.
New modulators of growth: the somatomedin-
binding proteins.
Rivista Italiana di Pediatria 18, 119-124, 1992.
25. Cianfarani S., Holly J.M.P., Pasquino A.M., Vaccaro F.,
Spadoni G.L., Bernardini S., Segni M., Boscherini B.
Insulin-like growth factor binding protein-1 (IGFBP-1)
levels in Turner syndrome.
Hormone and Metabolic Research 24, 537-540, 1992.
26. Pasquino A.M., Bernardini S., Cianfarani S., Mancuso G., Marchione S.A., Passeri F., Pucarelli I., Spadoni G.L.
Growth hormone assessment and three years' hGH therapy in girls with Turner syndrome.
Hormone Research 38, 120-124, 1992.
27. Tedeschi B, Spadoni G.L., Sanna M.L., Vernole P., Caporossi D., Cianfarani S., Nicoletti B, Boscherini B.
Increased chromosome fragility in lymphocytes of short normal children treated with recombinant human growth hormone.
Human Genetics 91, 459-463, 1993
28. Cianfarani S., Nicholl R.M., Medbach S., Charlesworth M.C., Savage M.O.
Idiopathic hypothalamus-pituitary dysfunction: review of five cases.
Hormone Research 39, 47-50, 1993.
29. Cianfarani S., Frost V.J., Savage M.O., Holly J.M.P.
Glucose does not influence the insulin-like growth factor (IGF) binding to carrier proteins (IGFBPs): analysis of rat and human serum by western ligand blotting.
Experientia (now Cellular and Molecular Life Sciences) 49, 699-701, 1993.
30. Cianfarani S., Vaccaro F., Pasquino A.M., Marchione S.A., Passeri F., Spadoni G.L., Bernardini S., Spagnoli A., Boscherini B.
Reduced growth hormone (GH) secretion in Turner syndrome: is body weight a key factor?
Hormone Research, 41, 27-32, 1994.
31. Bernardini S, Cianfarani S, Spagnoli A, Melino G, Annicchiarico-Petruzzelli M, Massoud R, Boscherini B, Finazzi-Agrò A, Rosenfeld RG, Federici G.
Expression and down regulation by retinoic acid of IGF binding protein-2 and 4 in medium from human neuroblastoma cells.
Journal of Neuroendocrinology 6, 409-413, 1994.
32. Cianfarani S, Vaccaro F, Boscherini B.
What is the rationale of growth hormone therapy in Turner syndrome?
Lancet 344, 114-115, 1994.
33. Cianfarani S., Boscherini B.
La sindrome di Noonan.
Prospettive in Pediatria 25, 25-32, 1995.
34. Bernardini S, Cianfarani S, Pianca C, Massoud R, Germani D, Melino G, Federici G.
Insulin-like growth factor binding protein-1 serum levels in neuroblastoma.
Clinical Chemistry and Enzimology Communications 6, 359-363, 1995.
35. Vaccaro F, Cianfarani S, Pasquino AM, Boscherini B.
Is the obesity- related insulin status the cause of the blunted growth hormone secretion in Turner syndrome?
Metabolism 44, 1033-1037, 1995.
36. Spagnoli A., Spadoni G.L., Cianfarani S., Pasquino A.M., Troiani S., Boscherini B.
Predicting outcome of growth hormone therapy in children with idiopathic short stature.
Journal of Pediatrics 126, 905-909, 1995.
37. Cianfarani S., Boemi S., Spagnoli A., Cappa M., Argirò G., Vaccaro F., Manca Bitti M.L., Boscherini B.
Is IGFBP-3 binding protein-3 assessment helpful for the diagnosis of GH deficiency?
Clinical Endocrinology 43, 43-47,1995.
38. Municchi G., Pasquino A.M., Pucarelli I., Cianfarani S., Passeri F.
Growth hormone treatment in Noonan syndrome: report of four cases who reached final height.
Hormone Research 44, 164-167,1995.
39. Cianfarani S., Vitale S., Stanhope R., Boscherini B.
Imperforate anus, bilateral hydronephrosis, bilateral undescended testes, and pituitary hypoplasia: a variant of Hall-Pallister syndrome or a new syndrome?
Acta Paediatrica 84, 1322-1324, 1995.
40. Spagnoli A., Branca F., Spadoni G.L., Cianfarani S., Pasquino A.M., Argirò G., Vitale S., Robins S.P., Boscherini B.
Urinary pyridinium collagen cross-links predict growth performance in children with idiopathic short stature and with growth hormone (GH) deficiency. Skeletal metabolism during GH treatment.
Journal of Clinical Endocrinology and Metabolism 81,3589-3593,1996.
41. Cianfarani S., Germani D., Rossi P., Spagnoli A., Mercanti D.
Do insulin-like growth factor binding proteins (IGFBPs) modulate the IGF-I growth promoting and differentiating effects in human neuroblastoma cells?
European Journal of Endocrinology 135, 716-723, 1996.
42. Cianfarani S., Rossi P.
Neuroblastoma and Insulin-like growth factor (IGF) system. New insights and clinical perspectives.
European Journal of Pediatrics 156, 256-261, 1997.
43. Cianfarani S., Boscherini B.
Il bambino con ritardo di crescita ad inizio intrauterino (IUGR, intrauterine growth retardation). Fisiopatologia dell’asse GH-IGF-I e tentativi terapeutici.
Prospettive in Pediatria 108, 299-306, 1997.
44. Cianfarani S, Tedeschi B, Germani D, Prete SP, Rossi P, Vernole P, Caporossi D, Boscherini B.
“In vitro” effects of growth hormone (GH) and insulin-like growth factor-I and -II (IGF-I and -II) on chromosome fragility and p53 protein expression in human lymphocytes.
European Journal of Clinical Investigation 28, 41-47, 1998.
45. Cianfarani S, Germani D, Rossi L, Argirò G, Boemi S, Lemon M, Holly JMP,
Branca F.
IGF-I and IGF-binding protein-1 are related to cortisol in human cord blood.
European Journal of Endocrinology 138, 524-529, 1998.
46. Balducci R, Toscano V, Tedeschi B, Mangiantini A, Toscano R, Galasso C, Cianfarani S, Boscherini B.
A new case of Ambras syndrome associated with a paracentric inversion (8) (q12:q22).
Clinical Genetics 53, 466-468, 1998.
47. Cianfarani S, Germani D, Rossi P, Rossi L, Germani A, Ossicini C, Zuppa A, Argirò G, Holly JMP, Branca F.
Intrauterine growth retardation (IUGR): Evidence for the activation of the IGF-related growth promoting machinery and the presence of a cation- independent IGFBP-3 proteolytic activity by two months of life.
Pediatric Research 44, 374-380, 1998.
48. Cianfarani S, Germani D, Branca F.
Low birth weight and adult insulin resistance: the catch-up growth hypothesis.
Archives of Disease in Childhood, 81, F71-F73, 1999.
49. Cianfarani S
Low birth weight and IGF system, Physiology and clinical implications.
Rivista di Clinica Dietologica 27, 89-92, 1999.
50. Puglianiello A, Germani D, Rossi P and Cianfarani S
Insulin-like growth factor-I (IGF-I) stimulates chemotaxis of human neuroblasts. Involvement of type I IGF receptor, insulin-like growth factor binding proteins (IGFBPs), phosphatidylinositol (PI)-3 kinase pathway and plasmin system.
Journal of Endocrinology 165, 123-131, 2000.
51. Rossi L., Branca F. and Cianfarani S.
Collagen cross-links and early postnatal growth in newborns with intrauterine growth retardation.
Metabolism 49, 1467-1472, 2000.
52. Elias LLK, Huebner A, Metherell LA, Canas A, Warne GL, Manca Bitti ML, Cianfarani S, Clayton PE, Savage MO, Clark AJL.
Tall stature in familial glucocorticoid deficiency.
Clinical Endocrinology 53, 423-430, 2000.
53. Cianfarani S, Bonfanti R, Manca Bitti ML, Germani D, Boemi S, Chiumello G, Boscherini B.
Growth and Insulin-like Growth Factors (IGFs) in Children with Insulin- Dependent Diabetes Mellitus (IDDM) at Onset of Disease. Evidence for Normal Growth, Age Dependency of the IGF System Alterations and Presence of a Small (18 kDa) IGFBP-3 Fragment in Serum.
Journal of Clinical Endocrinology and Metabolism 85, 4162-4167, 2000.
54. Cianfarani S, Geremia C, Germani D, Scirè G, Maiorana A, Boemi S.
Insulin resistance and insulin-like growth factors (IGFs) in children with intrauterine growth retardation (IUGR). Is catch-up growth a risk factor?
Hormone Research 55 (Suppl.1) 7-10, 2001.
55. Rossi L, Migliaccio S, Corsi A, Marzia M, Bianco P, Teti A, Gambelli L, Cianfarani S, Paoletti F, Branca F.
Reduced growth and skeletal changes in zinc deficient growing rats are the consequences of impaired growth plate activity and of zinc depletion-induced inanition.
Journal of Nutrition 131, 1142-1146, 2001.
56 Tadin M, Braverman E, Cianfarani S, Sobrino AJ,m Levy B, Christiano AM, Warburton D.
Complex cytogenetic rearrrangement of chromosome 8q in a case of Ambras syndrome.
American Journal of Medical Genetics 102, 100-104, 2001.
57. Branca F, Spagnoli A, Cianfarani S, Spadoni GL, Golden MHN, Boscherini B, Valtuena S, Robins SP.
Urinary excretion of pyridinium cross-links in short children treated with growth hormone.
Journal of Pediatric Endocrinology and Metabolism 15, 27-34, 2002.
58 Cianfarani S, Geremia C, Scott CD, Germani D.
Growth, Insulin-like growth factor (IGF) system and cortisol in children with intrauterine growth retardation (IUGR). Is catch-up growth affected by reprogramming of the hypothalamic-pituitary-adrenal axis (HPAA)?
Pediatric Research 51, 94-99, 2002.
59 Cianfarani S, Tondinelli T, Spadoni GL, Scirè G, Boemi S, Boscherini B.
Height Velocity and IGF-I Assessment in the Diagnosis of Childhood Onset GH Insufficiency. Do we still need a Second GH Stimulation Test?
Clinical Endocrinology 57, 161-167, 2002.
60 Cianfarani S.
Foetal origin of adult diseases: just a matter of stem cell number?
Medical Hypotheses 61:401-404, 2003.
61 Cianfarani S, Maiorana A, Geremia C, Scirè G, Spadoni GL, Germani D. Blood Glucose Concentrations are Reduced in Children Born Small for Gestational Age (SGA) and TSH Levels are Increased in SGA with Blunted Postnatal Catch- up Growth.
Journal of Clinical Endocrinology and Metabolism 88, 2699-2705, 2003.
62 Cianfarani S., Martinez C, Maiorana A, Scirè G, Spadoni G.L., Boemi S. Adiponectin Levels Are Reduced in Children Born Small for Gestational Age (SGA) and are Inversely Related to Postnatal Catch-up Growth.
Journal of Clinical Endocrinology and Metabolism 89: 1346-1351, 2004.
63 Scommegna S., Galeazzi D., Picone S., Farinelli E., Agostino R., Bozzao A., Boscherini B, Cianfarani S. Neonatal Identification of Pituitary Aplasia:a Life- Saving Diagnosis. Review of Five Cases.
Hormone Research 62, 10-16, 2004.
64 Geremia C, Cianfarani S.
Insulin sensitivity in children born small for gestational age (SGA)
Review of Diabetic Sciences 1, 58-65, 2004.
65 Cianfarani S.
La pubertà precoce.
Medico e Bambino 23, 485-491, 2004.
66 Torre P, Bertoli M, Di Giovanni S, Scommegna S., Conte C, Novelli G, Cianfarani S. Endocrine and Neuropsychological Assessment in a Child with a Novel Mutation of Thyroid Hormone Receptor. Response to 12-months Triiodothyroacetic Acid (TRIAC) Therapy.
Journal of Endocrinological Investigation 28, 657-662, 2005.
67 Cianfarani S, Liguori A, Germani D.
IGF-I and IGFBP-3 assessment in the management of childhood onset growth hormone deficiency.
Endocrine Development 9, 66-75, 2005
68 Cianfarani S.
Il ruolo dei fattori di crescita GH-dipendenti nella diagnosi del deficit di GH.
Area Pediatrica 4, 44-48, 2005.
69 Cianfarani S., Puglianiello A, Germani D.
Central reprogramming in intrauterine growth retardation.
Minerva Pediatrica 57(Suppl.1 N3):71-73, 2005.
70 Cianfarani S., Liguori A., Boemi S., Maghnie M, Iughetti L.,
Wasniewska M., Street M.E., Zucchini S., Aimaretti G.,
Grmani D.
Inaccuracy of IGFBP-3 Assessment in the Diagnosis of Growth Hormone
Deficiency (GHD) from Childhood to Young Adulthood: Association to
Low GH-Dependency of IGF-II and Presence of Circulating IGFBP-3 18 kD Fragment.
Journal of Clinical Endocrinological and Metabolism, 90, 6028-6034, 2005.
71 Cianfarani S, Ladaki C, Geremia C.
Hormonal regulation of post-natal growth in SGA children
Hormone Research 65 (Suppl. 3): 70-74, 2006.
72 Cianfarani S, Liguori A.
Sensibility and Specificity of Growth Factors in GH Deficiency.
Journal of Endocrinological Investigation, 29 (Suppl.), 71-75, 2006.
73. Geremia C, Cianfarani S.
Laboratory Tests and Measurements in Children
Born Small for Gestational Age (SGA)
Clinica Chimica Acta 364, 113-123, 2006.
74 Puglianiello A and Cianfarani S
Central control of glucose metabolism
The Review of Diabetic Studies 3, 54-60, 2006.
75 Kelberman D, Rizzoti K, Bitner-Glindzicz M, Cianfarani S, Collins J, Chong WK, Kirk JMW, Achermann JC, Ross R, Carmignac D, Lovell-Badge R, Robinson ICAF, Dattani MT
Mutations within Sox2/SOX2 are Associated with Hypopituitarism in Mouse and Humans.
Journal of Clinical Investigation 116, 2442-2455, 2006.
76 Scirè G, D’Anella G, Cristofori L, Mazzuca V, and Cianfarani S
Marked left ventricular hypertrophy mimicking hypertrophic cardiomyopathy associated with steroid therapy for congenital adrenal hyperplasia.
Journal of Cardiovascular Medicine 8(6):465-7, 2007
77. Federico G., Street M.E., Maghnie M., Caruso-Nicoletti M., Loche S., Bertelloni S., and Cianfarani S.
Assessment of circulating levels of insulin-like growth factors in the diagnosis diagnosis of isolated childhood-onset isolated growth hormone deficiency. A proposal of the Italian Society for Pediatric Endocrinology and Diabetes.
Journal of Endocrinological Investigation 29:732-737, 2006.
78. Ghirri P, Ladaki C, Bartoli A, Scirè G, Vuerich M, Spadoni GL, Maiorana M, Geremia C, Boldrini A , and Cianfarani S.
Low Birth Weight for Gestational Age Associates with Reduced Glucose Concentrations at Birth, Infancy and Childhood.
Hormone Research 67:123–131, 2007.
79. Clayton PE, Cianfarani S, Czernichow P, Johannsson G, Rapaport R, Rogol A
Management of the Child Born Small for Gestational Age Child (SGA) through to Adulthood: A Consensus Statement of the International Societies of Paediatric Endocrinology and the Growth Hormone Research Society.
Journal of Clinical Endocrinology and Metabolism 92, 804-810, 2007.
80. Antonella Puglianiello, Daniela Germani, Sara Antignani, Gianpaolo Scalia
Tomba and Stefano Cianfarani. Changes in the Expression of Hypothalamic Lipid Sensing Genes in Rat Model of Intrauterine Growth Retardation (IUGR).
Pediatric Research 61:433-437, 2007.
81. Zucchini S, Wasniewska M, Cisternino M, Salerno M, Iughetti L, Maghnie M, Street ME, Caruso-Nicoletti M, Cianfarani S.
Adult height in children with short stature and idiopathic delayed puberty after different management.
European Journal of Pediatrics 167, 677-681, 2008
82. Cianfarani S.
Endocrine-metabolic follow-up of the small for gestational age (SGA) infant.
Minerva Pediatr 59, 545-546, 2007
83. Cianfarani S, Geremia C, Puglianiello A, Mairana A, Germani D.
Late Effects of Disturbed IGF Signaling in Congenital Diseases.
Endocrine Development 11, 16-27, 2007.
84. Maiorana A, Del Bianco C, and Cianfarani S.
Adipose Tissue: a Metabolic Regulator. Potential Implications for the Metabolic Outcome of Subjects Born Small for Gestational Age (SGA).
The Review of Diabetic Studies, 4, 131-143, 2007.
85. Scirè G, Del Bianco C, Spadoni GL, and Cianfarani S
Growth hormone (GH) therapy does not alter the IGF-I/IGFBP-3 molar ratio in GH deficient children.
Journal of Endocrinological Investigation 31(2):153-8, 2008.
86. Torre P, Ladaki C, Scirè G, Spadoni GL, and Cianfarani S.
Catch-up growth in body mass index (BMI) is associated neither with reduced insulin sensitivity nor with altered lipid profile in children born small for gestational age (SGA).
Journal of Endocrinological Investigation 31(9):760-4, 2008.
87. Germani D, Puglianiello A and Cianfarani S.
Uteroplacental Insufficiency Down Regulates Insulin Receptor and Affects Expression of Key Enzymes of Long-chain Fatty Acid (LCFA) Metabolism in Skeletal Muscle at Birth.
Cardiovascular Diabetology, 7:14, 2008.
88. Elizabeth Brink, Veronique Coxam, Simon Robins, Kristiina Wahala, Aedin Cassidy, and Francesco Branca on behalf of the PHYTOS Investigators
Long-term consumption of isoflavone-enriched foods does not
affect bone mineral density, bone metabolism, or hormonal status in
early postmenopausal women: a randomized, double-blind, placebo
controlled study1.
Americal Journal of Clinical Nutrition 87:761–70, 2008.
89. Katherine A. Fantauzzo, Marija Tadin-Strapps, Yun You, Sarah E. Mentzer, Friedrich A.M. Baumeister, Stefano Cianfarani, Lionel Van Maldergem, Dorothy Warburton, John P. Sundberg and Angela M. Christiano.
A position effect on TRPS1 is associated with Ambras syndrome in humans and the Koala phenotype in mice.
Human Molecular Genetics 17(22):3539-51, 2008
90. P Cohen, AD Rogol, CL Deal, P Saenger, EO Reiter, JL Ross, SD Chernausek, MO Savage, JM Wit on behalf of the 2007 ISS Consensus Workshop participants*Consensus Statement on the Diagnosis and Treatment of Children with Idiopathic Short Stature: A Summary of the Growth Hormone Research Society, the Lawson Wilkins Pediatric Endocrine Society and the European Society for Paediatric Endocrinology Workshop.
Journal of Clinical Endocrinology and Metabolism 93(11):4210-4217. 2008.
91. Liguori A, Cianfarani S
Postnatal onset of severe growth retardation after in utero exposure to carbamazepine and phenobarbital: a case report
Journal of Medical Case Reports 2009; 3:7300 doi: 10.1186/1752-1947-3-7300
92 Pedicelli S, Peschiaroli E, Violi E, and Cianfarani S.
Controversies in the definition and treatment of idiopathic short stature (ISS).
Journal of Clinical Research in Pediatric Endocrinology. 2009; 1(3):105-115
93. Puglianiello A, Germani D, and Cianfarani S.
Exposure to uteroplacental insufficiency reduces the expression of signal transducer and activator of transcription 3 (STAT3) and proopiomelanocortin (POMC) in the hypothalamus of newborn rats.
Pediatric Research 66:208-211, 2009
94. Maiorana A, Fierabracci A and Cianfarani S
Isolation and characterization of omental adipose progenitor cells in children: a potential tool to unravel the pathogenesis of metabolic syndrome.
Hormone Research 2009;72:348–358
95. Maiorana A, Cianfarani S
Impact of Growth Hormone Therapy on Adult Height of Children Born Small for Gestational Age: A Systematic Review of Randomized Controlled Trials.
Pediatrics, 124, E519-E531, 2009.
96. Giacomozzi C, Savage MO and Cianfarani S
Deficit primario di IGF-I. Implicazioni diagnostico-terapeutiche.
Il Pediatra, giugno, 26-39. 2010
97. Bertelloni S, Garofalo P, and Cianfarani S.
Il ritardo dello sviluppo puberale maschile: trattamento con androgeni.
Rivista Italiana di Medicina dell’Adolescenza 8, 5-10,2010
98. Spadoni and Cianfarani S
Bone age assessment in the work up of children with endocrine disorders
Hormone Research in Paediatrics Vol. 73, No. 1, pp 2 - 5 , 2010
99. Giacomozzi C, Gullotta F, Federico G, Colapietro I, Nardone, AM, and Cianfarani S, Premature Ovarian Failure associated to the Absence of Pubic and Axillary Hair in a de novo Translocation X;15 (q24;q26.3).
American Journal of Medical Genetics 2010 May;152A(5):1305-9.
100. Giacomozzi C, Ghirri P, Lapolla R, Bartoli A, Scirè G, Serino L, Germani D, Boldrini A, and Cianfarani S.
Retinol-binding protein 4 in neonates born small for gestational age.
Journal of Endocrinological Investigation 2010 Apr;33(4):218-21.
101. Nobili V, Cianfarani S, Agostoni C.
Programming, metabolic syndrome, and NAFLD: the challenge of transforming a vicious into a virtuous cycle.
Journal of Hepatology 2010 Jun;52(6):788-90.
102. Federico G, Cianfarani S
Usefulness of serum insulin-like growth factor-I (IGF-I) assessment in the diagnosis of childhood-onset GH deficiency.
Hormone Research in Paediatrics 74, 145-148, 2010
103. Bertelloni S, Garofalo P, and Cianfarani S.
The role of androgen therapy in hypogonadal adolescent males
Homone Research in Paediatrics 74, 292-296, 2010
104. Cianfarani S
Grand Challenges in Pediatric Endocrinology
Frontiers in Pediatric Endocrinology doi:10.3389/fendo.2010.00001
105. Deodati A, Peschiaroli E, Cianfarani S.
Conseguenze endocrine e metaboliche del bambino nato SGA.
Rivista Italiana di Medicina dell’Adolescenza 3, Suppl. 8 1-6, ,2010
106. Liguori A, Puglianiello A, Germani D, Deodati A, Peschiaroli E and Cianfarani S,
Epigenetic changes predisposing to type 2 diabetes in intrauterine growth retardation.
Frontiers in Pediatric Endocrinology doi: 10.3389/fendo.2010.00005
107. Deodati A and Cianfarani S.
Impact of Growth Hormone Therapy on Adult Height of Children with Idiopathic Short Stature: A Systematic Review of Randomized and non-Randomized Controlled Trials.
British Medical Journal, 2011;342:c7157
108. Zanni G, Barresi S, Travaglini L, Bernardini L, Digilio MC, Mercuri E, Cianfarani S, Ferraris A, Masotti A, Novelli A, Valente EM, Dallapiccola B, Bertini ES
FGF17, a gene involved in cerebellar development is downregulated in a patient with Dandy-Walker Malformation carrying a de novo 8p deletion.
Neurogenetics 2011;12(3):241-5
109. Pedicelli S, Scirè G, Bertelloni S, Peschiaroli E, Deodati A, Garofalo P, Cianfarani S.
Il deficit di GH nel periodo di transizione (GH deficiency in the transition phase).
Il Pediatra 2011, giugno, 48-54
110. Fernando Cassorla, Stefano Cianfarani, Fritz Haverkamp, Jose Labarta, Sandro Loche, Xiaoping Luo, Mohammad Maghnie, Veronica Mericq, Agota Muzsnai, Svante Norgren, Marja Ojaniemi, Zuzana Pribilincova, Sofia Quinteiro, Lars Sävendahl, Angela Spinola e Castro, Christoph Gasteyger.
Growth Hormone and Treatment Outcomes: Expert Review of Current Clinical Practice
Pediatric Endocrinology Reviews, 2011 Dec;9(2):554-65.
111. Fernando Cassorla, Stefano Cianfarani, Fritz Haverkamp, Jose Labarta, Sandro Loche, Xiaoping Luo, Mohammad Maghnie, Veronica Mericq, Agota Muzsnai, Svante Norgren, Marja Ojaniemi, Zuzana Pribilincova, Sofia Quinteiro, Lars Sävendahl, Angela Spinola e Castro, Christoph Gasteyger.
Growth Hormone and Treatment Outcomes: Expert Review of Current Clinical Practice
Pediatric Endocrinology Reviews, Dec;9(2):554-65, 2011
112. Deodati A, Peschiaroli E, and Cianfarani S.
Review of Growth Hormone Randomized Controlled Trials in Children with Idiopathic Short Stature.
Hormone Research in Paediatrics 76 (Suppl. 3):40B-42 (DOI: 10.1159/000330157), 2011
113. Canani RB, Di Costanzo M, Leone L, Bedogni G, Brambilla P, Cianfarani S,
Nobili V, Pietrobelli A, Agostoni C. Epigenetic mechanisms elicited by nutrition in early life.
Nutr Res Rev. Dec;24(2):198-205, 2011
114. Cianfarani S.
Chairman's summary: Diagnostic techniques for identifying children with idiopathic short stature.
Horm Res Paediatr. 76 Suppl 3:16.Epub 2011 Sep 7, 2011.
115. Cohen A, Lala R, Ravaglia A, Bernasconi S, Boscherini B, Cianfarani S, Pocecco M, Maghnie M, Panei P
Modifiche della prescrizione dell’ormone della crescita. Una proposta dell’ACP. QUADERNI ACP, vol. 18, p. 42-44, 2011
116. Alisi A, Cianfarani S, Manco M, Agostoni C, Nobili V.
Nonalcoholic fatty liver disease and metabolic syndrome in adolescents: pathogenetic role of genetic background and intrauterine environment.
Annals of Medicine, Feb;44(1):29-40 2012
117. S. Cianfarani, C. Agostoni, G. Bedogni, R. Berni Canani, P. Brambilla, V. Nobili, A. Pietrobelli
Effect of Intrauterine Growth Retardation on Liver and Long-Term Metabolic Risk.
International Journal of Obesity. Oct;36(10):1270-7, 2012.
118. G. Bedogni, G. Giannone, M. Maghnie, C. Giacomozzi, N. Di Iorgi, S. Pedicelli, E. Peschiaroli, G. Melioli, M. Muraca, M. Cappa, and S. Cianfarani.
Serum insulin-like growth factor-I (igf-I) reference ranges for chemiluminescence assay in childhood and adolescence. Data from a population of in- and out-patients.
Growth Hormone and IGF Research, 22:134-138, 2012.
119. Nobili V, Bedogni G, Berni Canani R, Brambilla P, Cianfarani S, Pietrobelli A, Agostoni C
The Hepato-Metabolic Syndrome In Children: A Distinct Phenotype With High Metabolic Risk?
Pediatric Obesity Dec;7(6):e75-80, 2012.
120. Cianfarani S
Long-term safety of growth hormone therapy: still a controversial issue.
Frontiers in endocrinology, vol. 3, p. 1-2, 2012. doi: 10.3389/fendo.2012.00115
121. Cianfarani S
Insulin-like growth factor-II (IGF-II): new roles for an old actor.
Frontiers in endocrinology, vol.3, 1-4, 2012, doi: 10.3389/fendo. 2012.00118
122. Benevento D, Bizzarri C, Patera IP, Ravà L, Schiaffini R, Ciampalini P, Cianfarani S, Cappa M.
Birth weight influences the clinical phenotype and the metabolic control of patients with type 1 diabetes (T1D) .
Diabetes/metabolism research and reviews Jan;29(1):60-5, 2013
123. Inzaghi E and Cianfarani S
The challenge of growth hormone deficiency (GHD) diagnosis and treatment during the transition from puberty into adulthood.
Frontiers in Endocrinology 4:34. doi: 10.3389/fendo.2013.00034, 2013
124. Wit. JM. Ranke MB, Albertsson-Wikland K, Carrascosa A, Rosenfeld RG, Van Buuren S, Kristom B, Schoenau E, Audi L, Hokken.Koelega A, Bamg P, Junh H, Blum WF, Silverman LA, COhen P, Cianfarani S, Deal C, Clayton PE, de Graaf L, Dahlgren J, Kleintjens J, Roelants M.
Personalized approach to growth hormone treatment: clinical use of growth prediction models.
Horm Res Paediatr. 79(5):257-70, 2013
125. Deodati A, Inzaghi E, Liguori A, Puglianiello A, germani D, Brufani C, Fintini D, Cappa M, Barbetti F, Cianfarani S.
IGF2 Methylation Is Associated with Lipid Profile in Obese Children.
Horm Res Paediatr, Jun 14:361-367, 2013
126. Bizzarri C, Benevento D, Patera IP, Bongiovanni M, Boiani A, Cianfarani S, Cappa M
Residual beta-cell mass influences growth of pre-pubertal children with type 1 diabetes.
Horm Res Paediatr 80(4):287-92, 2013
127. Bizzarri C, Spadoni GL, Bottaro G, Monatanari G, Giannone G, Cappa M, Cianfarani S.
The response to gonadotropin releasing hormone (GnRH) stimulation test does not predict the progression to true precocious puberty in girls with onset of premature thelarche in the first three years of life.
Journal of Clinical Endocrinology and Metabolism, 99(2):433-9, 2014.
128. Valerio Nobili, Valentina Giorgio, Daniela Liccardo, Giorgio Bedogni, Giuseppe Morino, Anna Alisi, and Stefano Cianfarani.
Vitamin D levels and liver histological alterations in children with non-alcoholic fatty liver disease (NAFLD).
European Journal of Endocrinology 170(4):547-53, 2014.
129. Boscherini B and Cianfarani S.
Considerazioni sulla diagnosi di deficienza idiopatica isolata di ormone della crescita
Quaderni ACP 21(1): 31-32, 2014.
130. Cafiero G, Fintini D, Brufani C, Fiori R, Giordano U, Turchetta A, Deodati A, Cappa M and
Cianfarani S
Cardiovascular fitness is impaired in children that are born small for their gestational age.
Acta Paediatrica 103(5):e219-21, 2014
131. Stefano Cianfarani, Elena Inzaghi, Anna Alisi, Daniela Germani, Antonella Puglianiello, V alerio Nobili.
Insulin-like Growth Factor–I and –II Levels are Associated with the Progression of Nonalcoholic Fatty Liver Disease in Obese Children.
Journal of Pediatrics 165(1):92-8, 2014.
132. Annalisa Deodati, Barbara Baldini Ferroli and Stefano Cianfarani.
Association between Growth Hormone Therapy and Mortality, Cancer and Cardiovascular Risk: Systematic Review and Meta-Analysis.
Growth Hormone and IGF Research 24:105-111, 2014.
133. Elena Inzaghi, Stefano Cianfarani, Valerio Nobili.
Insulin-Like Growth Factors (IGF-I And –II): New Actors in the Development of Non-Alcoholic Fatty Liver Disease.
Expert Reviews of Endocrinology and Metabolism 9:193-195, 2014.
134. S. Cianfarani
Is High Dose Growth Hormone Treatment During Puberty Worthwhile?
Hormone Research in Paediatrics, 82(3):143-4, 2014
135. Cianfarani S
Editorial
Hormone Research in Paediatrics 81:1, 2014
136 Bizzarri C, Benevento D, Giannone G, Bongiovanni M, Anziano M, Patera IP, Cappa M and Cianfarani S. Sexual dimorphism in growth and insulin-like growth factor-I in children with type 1 diabetes mellitus.
Growth Hormone and IGF Research, 24(6):256-9, 2014.
137 Carla Bizzarri, Stefania Pedicelli, Brunetto Boscherini, Giorgio Bedogni, Marco Cappa and Stefano Cianfarani
Early retesting by GHRH + arginine test shows normal GH response in most children with idiopathic GH deficiency.
Journal of Endocrinological Investigation, Apr;38(4):429-36, 2015
138. Stefania Pedicelli, Paola Alessio, Giuseppe Scirè, Marco Cappa, and Stefano Cianfarani.
Routine Screening by Brain Magnetic Resonance Imaging Is not Indicated in Every Girl with Onset of Puberty Between the Ages of Six and Eight Years.
Journal of Clinical Endocrinology and Metabolism, 99(12):4455-61, 2014.
139. V. Pampanini, A. Boiani, C. De Marchis, C. Giacomozzi, R. Navas, R. Agostino, F. Dini, P.Ghirri, and S. Cianfarani
Preterm Infants with Severe Extrauterine Growth Retardation (EUGR) Are at High Risk of Growth Impairment during Childhood.
European Journal of Pediatrics, 174(1):33-41, 2015.
140. C. Giacomozzi, A. Deodati, M.G. Shaikh, S.F. Ahmed, and S. Cianfarani.
The Impact of Growth Hormone Therapy on Adult Height in Noonan Syndrome: a systematic review.
Hormone Research in Paediatrics, 83(3):167-76, 2015.
141. D. Fintini, E. Inzaghi, M. Colajacomo, S. Bocchini, G. Grugni, C. Brufani, M. Cappa, V. Nobili, S. Cianfarani, A. Crinò
Non-Alcoholic Fatty Liver Disease (NAFLD) in children and adolescents with Prader–Willi Syndrome (PWS).
Pediatric Obesity 11(3):235-8, 2016
142 Swerdlow AJ, Cooke R, Albertsson-Wikland K, Borgström B, Butler G, Cianfarani S, Clayton P, Coste J, Deodati A, Ecosse E, Gausche R, Giacomozzi C, Kiess W, Hokken-Koelega AC, Kuehni CE, Landier F, Maes M, Mullis PE, Pfaffle R, Sävendahl L, Sommer G, Thomas M, Tollerfield S, Zandwijken GR, Carel JC.
Description of the SAGhE Cohort: A Large European Study of Mortality and Cancer Incidence Risks after Childhood Treatment with Recombinant Growth Hormone.
Hormone Research in Paediatrics, 84, 172-183, 2015.
143. Pampanini V, Pedicelli S, Gubinelli J, Scirè G, Cappa M, Boscherini B, and Cianfarani S.
Brain Magnetic Resonance Imaging as First-Line Investigation for Growth Hormone Deficiency Diagnosis in Early Childhood.
Hormone Research in Paediatrics, 84(5):323-30, 2015.
144. D B Allen, P Backeljauw, M Bidlingmaier, BMK Biller, M Boguszewski , P Burman, G Butler, K Chihara, J Christiansen, S Cianfarani, P Clayton, D Clemmons, P Cohen, F Darendeliler, C Deal, D Dunger, E M Erfurth, J S Fuqua, A Grimberg, M Haymond, C Higham, K Ho, A R Hoffman, A Hokken-Koelega, G Johannsson, A Juul, J Kopchick, P Lee, M Pollak, S Radovick, L Robison, R Rosenfeld, R J Ross, L Savendahl, P Saenger, H Toft Sorensen, K Stochholm, C Strasburger, A Swerdlow, M Thorner.
Growth Hormone Safety Workshop Position Paper: a critical appraisal of recombinant human growth hormone therapy in children and adults.
Eur J Endocrinol. 174(2):P1-9, 2016.
145. Schiaffini R, Liccardo D, Alisi A, Benevento D, Cappa M, Cianfarani S, Nobili V
Early Glucose Derangement Detected by Continuous Glucose Monitoring and Progression of Liver Fibrosis in Nonalcoholic Fatty Liver Disease: An Independent Predictive Factor?
Hormone Research in Paediatrics 85(1):29-34, 2016.
146. Brambilla P, Bedogni G, Pietrobelli A, Cianfarani S , Agostoni C.
Predictors of blood pressure at 7-13 years: The “new Millennium Baby” study.
Nutrition, Metabolism and Cardiovascular Diseases. 26(8):706-12, 2016
147. Deodati A, Sallemi A, Maranghi , Germani D, Puglianiello A, Baldari F, Busani L, Mancini FR, Tassinari R, Mantovani A, Cianfarani S
Serum Levels of Polybrominated Diphenyl Ethers in Girls with Premature Thelarche.
Hormone research in Paediatrics 86(4):233-239, 2016.
148. Savage MO, Backeljauw PF, Calzada R, Cianfarani S, Dunkel L, Koledova E, Wit JM, Yoo HW.
Early Detection, Referral, Investigation, and Diagnosis of Children with Growth Disorders.
Hormone Research in Paediatrics 85(5):325-32, 2016
149. Fischer-Posovszky P, Roos J, Kotnik P, Battelino T, Inzaghi E, Nobili V, Cianfarani S, Wabitsch M.
Functional Significance and Predictive Value of MicroRNAs in Pediatric Obesity: Tiny Molecules with Huge Impact.
Hormone research in Paediatrics 86(1):3-10, 2016.
150. M. Cappa, L. Iughetti, S. Loche, M. Maghnie, A. Vottero. GeNeSIS National Board on behalf of the GeNeSIS Italian Investigators.
Efficacy and safety of growth hormone treatment in children with short stature: the Italian cohort of the GeNeSIS clinical study.
Journal of Endcorinological Investigation 39:667–677, 2016
151. Cambiaso P, Bottaro G, Cianfarani S, Tomà P, de Vito R, Cappa M.
An Incidental Finding of Bilateral Adrenal Lymphoma
The American Journal of Medical Sciences 52(1):80. doi: 10.1016/j.amjms.2016.02.018., 2016.
152. Bizzari C, Pedicelli S, Cappa M, Cianfarani S.
Water Balance and 'Salt Wasting' in the First Year of Life: The Role of Aldosterone-Signaling Defects.
Hormone Research in Paediatrics 86(3):143-153., 2016.
153. Deodati A, Cianfarani S.
Trattamento con ormone della crescita in bambini nati piccoli per l’età gestazionale
L’Endocrinologo 17(4):183-187, 2016
154. Cianfarani S, Soder O.
Endocrine disruptors and child health. New insights.
Hormone Research in Paediatrics Sep 16;86(4), 2016
155. Della Corte C, Carpino G, De Vito R, De Stefanis C, Alisi A, Cianfarani S, Overi D, Mosca A, Stronati L, Cucchiara S, Raponi M, Gaudio E, Byrne CD, Nobili V.
Docosahexanoic Acid Plus Vitamin D Treatment Improves Features of NAFLD in Children with Serum Vitamin D Deficiency: Results from a Single Centre Trial.
PLoS One. 2016 Dec 15;11(12):e0168216. doi: 10.1371/journal.pone.0168216.
156. Pampanini V, Germani D, Puglianiello A, Stukenborg JB, Reda A, Savchuk I, Kjartansdóttir KR, Cianfarani S, Soder O.
Impact of uteroplacental insufficiency on postnatal rat male gonad.
Journal of Endocrinology Feb;232(2):247-257, 2017.
157. Swerdlow AJ, Cooke R, Beckers D, Borgström B, Butler G, Carel JC, Cianfarani S, Clayton P, Coste J, Deodati A, Ecosse E, Gausche R, Giacomozzi C, Hokken-Koelega AC, Khan AJ, Kiess W, Kuehni CE, Mullis PE, Pfaffle R, Sävendahl L, Sommer G, Thomas M, Tidblad A, Tollerfield S, Van Eycken L, Zandwijken GR.
Cancer risks in patients treated with growth hormone in childhood: the SAGHE European cohort study.
Journal of Clinical Endocrinology and Metabolism 102:1661–1672, 2017.
158. Elena Inzaghi, Barbara Baldini Ferroli, Danilo Fintini, Armando Grossi, Valerio Nobili, Stefano Cianfarani
Insulin-Like Growth Factors and Metabolic Syndrome in Obese Children.
Hormone research in Paediatrics 87:400–404, 2017.
159. Francesca Santilli, Paola G. Simeone, Maria T. Guagnano, Marika Leo, Marica T. Maccarone, Augusto Di Castelnuovo, Cristina Sborgia, Riccardo C. Bonadonna, Ermanno Angelucci, Virginia Federico, Stefano Cianfarani, Lamberto Manzoli, Giovanni Davì, Armando Tartaro and Agostino Consoli.
Effects of Liraglutide on Weight Loss, Fat Distribution, and β-Cell Function in Obese Subjects with Prediabetes or Early Type 2 Diabetes.
Diabetes Care 2017 Nov;40(11):1556-1564
160 Deodati A, Cianfarani S.
The rationale for growth hormone therapy in children with short stature.
Journal of Clinical Research in Pediatric Endocrinology Dec 30;9(Suppl 2):23-32, 2017.
161 S. Brandt, J. Roos, E. Inzaghi, P. Kotnik, J. Kovac, T. Battelino, S. Cianfarani,
V. Nobili, M. Colajacomo, W. Kratzer, C. Denzer, P. Fischer-Posovszky and M. Wabitsch
Circulating levels of miR-122 and nonalcoholic fatty liver disease in pre-pubertal obese children.
Pediatric Obesity 13(3):175-182, 2018.
162 Pampanini V, Inzaghi E, Germani D, Alterio A, Puglianiello A, Alisi A, Nobili V and Cianfarani S
Serum Fetuin-A Levels in Obese Children with Biopsy Proven Nonalcoholic
Fatty Liver Disease.
Nutrition, Metabolism & Cardiovascular Diseases Jan;28(1):71-76, 2018.
163 Bizzarri C, Timpanaro TA, Matteoli MC, Patera IP, Cappa M, Cianfarani S.
Growth trajectory in children with type 1 diabetes mellitus: the impact of insulin treatment and metabolic control.
Hormone Research in Paediatrics. 89(3):172-177, 2018
164 Cinzia La Rocca, Francesca Maranghi, Sabrina Tait, Roberta Tassinari, Francesca Baldi, Giorgia Bottaro, Emma Buzzigoli, Fabrizia Carli, Stefano Cianfarani, Raffaele Conte, Annalisa Deodati, Amalia Gastaldelli, Anna Paola Pala, Andrea Raffaelli, Chiara Saponaro, Giuseppe Scirè, Gian Luigi Spadon, Luca Busani, the LIFE PERSUADED Project Group.
The LIFE PERSUADED project approach on phthalates and bisphenol A biomonitoring in Italian mother-child pairs linking exposure and juvenile diseases.
Environmental Science and Pollution Research, Jul 4. doi: 10.1007/s11356-018-2660-4, 2018.
165 Annalisa Deodati, Josepmaría Argemí, Daniela Germani, Antonella Puglianiello, Anna Alisi, Cristiano De Stefanis, Roberto Ferrero, Valerio Nobili, Tomás Aragón,
Stefano Cianfarani
The exposure to uteroplacental insufficiency is associated with activation of unfolded protein response in postnatal life.
PLOS ONE Jun 13;13(6):e0198490. doi: 10.1371/journal.pone.0198490., 2018
166 Anna Alisi, Valentina Pampanini, Cristiano De Stefanis, Nadia Panera, Annalisa Deodati,
Valerio Nobili, Stefano Cianfarani
Expression of insulin-like growth factor I and its receptor in the liver of children with biopsy-proven NAFLD.
PLOS ONE Jul 31;13(7):e0201566. 2018
167 Marzano F, Faienza MF, Caratozzolo MF, Brunetti G, Chiara M, Horner DS, Annese A, D’erchia AM, Consiglio A Pesole G, Sbisà E, Inzaghi E, Cianfarani S, Tullo A.
Pilot study on circulating miRNA signature in children with obesity born small for gestational age and appropriate for gestational age.
Pediatric Obesity Dec;13(12):803-811. 2018
168 Inzaghi E, Reiter E, Cianfarani S.
The Challenge of Defining and Investigating the Causes of Idiopathic Short Stature and Finding an Effective Therapy.
Hormone Research in Paediatrics, 92(2):71-83, 2019
169 Binder G, Reinehr T, Ibáñez L, Thiele S, Linglart A, Woelfle J, Saenger P, Bettendorf M, Zachurzok A, Gohlke B, Randell T, Hauffa BP, Claahsen van der Grinten HL, Holterhus PM, Juul A, Pfäffle R, Cianfarani S.
GHD Diagnostics in Europe and the US: An Audit of National Guidelines and Practice.
Hormone Research in Paediatrics, 92(2):71-83, 2019
170 Cianfarani S
Pediatric endocrinology in the time of COVID-19 pandemic
Hormone Research in Paediatrics 92(6):345-346, 2019
171 Pampanini V, Jahnukainen K, Sahlin L, Germani D, Puglianiello A, Cianfarani S, Söder O
Impact of uteroplacental insufficiency on ovarian follicular pool in the rat.
Reproductive Biology and Endocrinology, Jan 10;17(1):10, 2019
172 Swerdlow AJ, Cooke R, Beckers D, Butler G, Carel JC, Cianfarani S, Clayton P, Coste J, Deodati A, Ecosse E, Hokken-Koelega ACS, Khan AJ, Kiess W, Kuehni CE, Flück CE, Pfaffle R, Sävendahl L, Sommer G, Thomas M, Tidblad A, Tollerfield S, Zandwijken GRJ.
Risk of Meningioma in European Patients Treated with Growth Hormone in Childhood: Results from the SAGhE Cohort.
Journal of Clinical Endocrinology and Metabolism, Mar 1;104(3):658-664, 2019.
173 Spreghini N, Cianfarani S, Spreghini MR, Brufani C, Morino GS, Inzaghi E, Convertino A, Fintini D, Manco M.
Oral glucose effectiveness and metabolic risk in obese children and adolescents
Acta Diabetologica, Aug;56(8):955-962, 2019
174 Centonze C, Guzzetti C, Orlando G, Loche S; Italian ECOS Investigators.
Adherence to growth hormone (GH) therapy in naïve to treatment GH-deficient children: data of the Italian Cohort from the Easypod Connect Observational Study (ECOS)
Journal of Endocrinological Investigation, Oct;42(10):1241-1244, 2019.
175 Bizzarri C, Pedicelli S, Romanzo A, Bocchini S, Bottaro G, Cianfarani S, Cappa M.
The impact of IGF-I, puberty and obesity on early retinopathy in children: a cross-sectional study.
Italian Journal of Pediatrics Apr 27;45(1):52, 2019.
176 Cianfarani S
Risk of cancer in patients treated with recombinant human growth hormone in childhood.
Annals of Pediatric Endocrinology and Metabolism, Jun;24(2):92-98, 2019
177 Nobili V, Mantovani A, Cianfarani S, Alisi A, Mosca A, Sartorelli MR, Maffeis C, Loomba R, Byrne CD, Targher G.
Prevalence of prediabetes and diabetes in children and adolescents with biopsy-proven non-alcoholic fatty liver disease.
Journal of Hepatology, Oct;71(4):802-810, 2019.
178 Inzaghi E, Kistner A, Germani D, Deodati A, Vanpee M, Legnevall L, Berinder K, Cianfarani S.
A prospective case-control study on miRNA circulating levels in subjects born small for gestational age (SGA) evaluated from childhood into young adulthood.
PloS One, Jan 24;15(1):e0228075, 2020
179 Deodati A, Inzaghi E, Cianfarani S.
Epigenetics and In Utero Acquired Predisposition to Metabolic Disease.
Frontiers in Genetics, Jan 29;10:127, 2020.
180 Tassinari R, Narciso L, Tait S, Busani L, Martinelli A, Di Virgilio A, Carli F, Deodati A, La Rocca C, Maranghi F; LIFE PERSUADED Project Group.
Juvenile Toxicity Rodent Model to Study Toxicological Effects of Bisphenol A (BPA) at Dose Levels Derived from Italian Children Biomonitoring Study.
Toxicological Sciences, Feb 1;173(2):387-401, 2020
181 Tait S, Carli F, Busani L, Buzzigoli E, Della Latta V, Deodati A, Fabbrizi E, Gaggini M, Maranghi F, Tassinari R, Toffol G, Cianfarani S, Gastaldelli A, La Rocca C; LIFE PERSUADED Project Group.
Biomonitoring of Bis(2-ethylhexyl)phthalate (DEHP) in Italian children and adolescents: Data from LIFE PERSUADED project.
Environmental Research, Jun;185:109428, 2020
182 Fintini D, Cianfarani S, Cofini M, Andreoletti A, Ubertini GM, Cappa M, Manco M.
The bones of children with obesity.
Frontiers in Endocrinology, Apr 24;11:200, 2020.
183 Schiaffini R, Barbetti F, Rapini N, Inzaghi E, Deodati A, Patera IP, Matteoli MC, Ciampalini P, Carducci C, Lorubbio A, Schiaffini G, Cianfarani S.
School and pre-school children with type 1 diabetes during Covid-19 quarantine: The synergic effect of parental care and technology.
Diabetes Research in Clinical Practice, Aug;166:108302, 2020.
184 Sävendahl L, Cooke R, Tidblad A, Beckers D, Butler G, Cianfarani S, Clayton P, Coste J, Hokken-Koelega ACS, Kiess W, Kuehni CE, Albertsson-Wikland K, Deodati A, Ecosse E, Gausche R, Giacomozzi C, Konrad D, Landier F, Pfaeffle R, Sommer G, Thomas M, Tollerfield S, Zandwijken GRJ, Carel JC, Swerdlow AJ.
Long-term mortality after childhood growth hormone treatment: the SAGhE cohort study.
Lancet diabetes and Endocrinology, Aug;8(8):683-692, 2020
185 Amodeo ME, Inzaghi E, Deodati A, Cianfarani S.
Endocrinological features of a patient with 14q microdeletion and Dubowitz phenotype.
Mol Genet Genomic Med.May 31;e1644. doi: 10.1002/mgg3.16, 2021.
186 Petrelli A, Ravà L, Mascali A, Rapini N, Massoud M, Manca Bitti ML, Cianfarani S, Manco M.
Estimated insulin sensitivity, cardiovascular risk, and hepatic steatosis after 12 years from the onset of T1D
Diabetes Metab Res Rev. Jun 2:e3479, 2021.
187 Inzaghi E, Deodati A, Loddo S, Mucciolo M, Verdecchia F, Sallicandro E, Catino G, Cappa M, Novelli A,Cianfarani S.
Prevalence of copy number variants (CNVs) and rhGH treatment efficacy in an Italian cohort of children born small for gestational age (SGA) with persistent short stature associated with a complex clinical phenotype
J Endocrinol Invest. Jan;45(1):79-87, 2022
188 Cianfarani S, Pampanini V
The Impact of Stress on Health in Childhood and Adolescence in the Era of the COVID-19 Pandemic
Horm Res Paediatr. Jul 14:345-349, 2021
189 Giglione E, Lapolla R, Cianfarani S, Faienza MF, Fintini D, Weber G, Delvecchio M, Valerio G.
Linear growth and puberty in childhood obesity: what is new?
Minerva Pediatr (Torino). Dec;73(6):563-571, 2021.
190 Carducci C, Rapini N, Deodati A, Pampanini V, Cianfarani S, Schiaffini R.
Post-traumatic stress disorder (PTSD) in parents of children with type 1 diabetes during Covid-19 pandemic.
Ital J Pediatr. Aug 26;47(1):176, 2021.
191 Tait S, Carli F, Busani L, Ciociaro D, Della Latta V, Deodati A, Fabbrizi E, Pala AP, Maranghi F, Tassinari R, Toffol G, Cianfarani S, Gastaldelli A, La Rocca C, Life Persuaded Project Group.
Italian Children Exposure to Bisphenol A: Biomonitoring Data from the LIFE PERSUADED Project.
Int J Environ Res Public Health. Nov 12;18(22):11846, 2021.
192 Stefano Cianfarani.
Safety of Pediatric rhGH Therapy: An Overview and the Need for Long-Term Surveillance
Frontiers in Endocrinology, Dec 24;12:811846, 2021.
193 Zucchini S, Di Iorgi N, Pozzobon G, Pedicelli S, Parpagnoli M, Driul D, Matarazzo P, Baronio F, Crocco M, Giudica G, Partenope C, Nardini B, Ubertini G, Menardi R, Guzzetti C, Iughetti L, Aversa T, Di Mase R, Cassio A, Cianfarani S, Maghnie M, Tuli G, Loche S, Bruzzi P, Wasniewska M, Salerno M, Rutigliano I, Iezzi ML, Cherubini V, Grandone A, Faienza M, Tumini S, Baldoli C, Consales A, Genitori L, Marras CE, MIlanaccio C, Mortini P, Vindigni M, Zenga F, Zucchelli M; Physiopathology of Growth Processes; Puberty Study Group of the Italian Society for Pediatric Endocrinology and Diabetology.
Management of Childhood-onset Craniopharyngioma in Italy: A Multicenter, 7-Year Follow-up Study of 145 Patients
J Clin Endocrinol Metab. Feb 17;107(3):e1020-e1031, 2022.
194 Stefania Pedicelli, Danilo Fintini, Lucilla Ravà, Elena Inzaghi, Annalisa Deodati, Maria Rita Spreghini, Carla Bizzarri, Michela Mariani, Stefano Cianfarani, Marco Cappa, Melania Manco,
Prevalence of prediabetes in children and adolescents by class of obesity.
Pediatr Obes. Feb 10;e12900, 2022
195 Giorgia Sforza, Annalisa Deodati, Romina Moavero, Laura Papetti, Ilaria Frattale,Federico Vigevano, Stefano Cianfarani, Massimiliano Valeriani.
Benign Intracranial Hypertension Due to Hypoparathyroidism: A Case Report.
Frontiers in Neurology, Jan 10;12:818638, 2022
196 Arianna Petrelli, Lucilla Ravà, Alberto Mascali, Novella Rapini, Michela Massoud, Maria Luisa Manca Bitti, Stefano Cianfarani, Melania Manco.
Estimated insulin sensitivity, cardiovascular risk, and hepatic steatosis after 12 years from the onset of T1D.
Diabetes Metab Res Rev., Jan;38(1):e3479, 2022
197 Conor McClenaghan, Novella Rapini, Domenico Umberto De Rose, Jian Gao, Jacob Roeglin, Carla Bizzarri, Riccardo Schiaffini, Eloisa Tiberi, Mafalda Mucciolo, Annalisa Deodati, Alessandro Perri, Giovanni Vento, Fabrizio Barbetti, Colin G Nichols, Stefano Cianfarani.
Sulfonylurea-insensitive permanent neonatal diabetes caused by a severe gain-of-function Tyr330His substitution in Kir6.2.
Horm Res Paediatr. Jan 7. doi: 10.1159/000521858, 2022.
198 Annalisa Deodati, Elena Inzaghi, Daniela Germani, Francesca Fausti, Stefano Cianfarani.
Crk Haploinsufficiency Is Associated with Intrauterine Growth Retardation and Severe
Postnatal Growth Failure.
Horm Res Paediatr, Jan 27;1-11. doi: 10.1159/000521629, 2022
199 Schiaffini R, Deodati A, Nicoletti MC, Carducci C, Ciampalini P, Lorubbio A, Matteoli MC, Pampanini V, Patera IP, Rapini N, Cianfarani S.
Comparison of two advanced hybrid closed loop in a pediatric population with type 1 diabetes: a real-life observational study.
Acta Diabetologica 59:959-964, 2022
200 Inzaghi E, Pampanini V, Deodati A and Cianfarani S
The effects of nutrition on linear growth
Nutrients 14(9):1752, 2022
201 Boguszewski MCS, Boguszewski CL, Chemaitilly W, Cohen LE, Gebauer J, Higham C, Hoffman AR, Polak M, Yuen KCJ, Alos N, Antal Z, Bidlingmaier M, Biller BMK, Brabant G, Choong CSY, Cianfarani S, Clayton PE, Coutant R, Cardoso-Demartini AA, Fernandez A, Grimberg A, Guðmundsson K, Guevara-Aguirre J, Ho KKY, Horikawa R, Isidori AM, Jørgensen JOL, Kamenicky P, Karavitaki N, Kopchick JJ, Lodish M, Luo X, McCormack AI, Meacham L, Melmed S, Mostoufi Moab S, Müller HL, Neggers SJCMM, Aguiar Oliveira MH, Ozono K, Pennisi PA, Popovic V, Radovick S, Savendahl L Touraine P, van Santen HM, Johannsson G.
Safety of growth hormone replacement in survivors of cancer and intracranial and pituitary tumours: a consensus statement.
European Journal of Endocrinology, 186(6):P35-P52, 2022
202 Pampanini V, Deodati A, Inzaghi E, Cianfarani S.
Long-acting growth hormone preparations and their use in children with growth hormone deficiency.
Hormone Research in Paediatrics Feb 25. doi: 10.1159/000523791, 2022
203 Barbetti F, Rapini N, Schiaffini R, Bizzarri C, Cianfarani S.
The application of precision medicine in monogenic diabetes.
Expert Rev Endocrinol Metab. Mar;17(2):111-129, 2022
204 Dunger DB, Bruggraber SFA, Mander AP, Marcovecchio ML, Tree T, Chmura PJ, Knip M, Schulte AM, Mathieu C; INNODIA consortium.
INNODIA Master Protocol for the evaluation of investigational medicinal products in children, adolescents and adults with newly diagnosed type 1 diabetes
Trials. 2022 May 18;23(1):414. doi: 10.1186/s13063-022-06259-z.
205 Novella Rapini, Patrizia I. Patera, Riccardo Schiaffini, Paolo Ciampalini, Valentina Pampanini, Matteoli M. Cristina, Annalisa Deodati, Giorgia Bracaglia, Ottavia Porzio, Rosario Ruta, Antonio Novelli, Mafalda Mucciolo, Stefano Cianfarani, Fabrizio Barbetti.
Monogenic diabetes clinic (MDC): 3‐year experience
Acta Diabetologica Sep 30. doi: 10.1007/s 00592-022-01972-2, 2022
206 Del Chierico F, Conta G, Matteoli MC, Fierabracci A, Reddel S, Macari G, Gardini S, Guarrasi V, Levi Mortera S, Marzano V, Vernocchi P, Sciubba F, Marini F, Deodati A, Rapini N, Cianfarani S, Miccheli A, Putignani L
Gut Microbiota Functional Traits, Blood pH, and Anti-GAD Antibodies Concur in the Clinical Characterization of T1D at Onset.
Int J Mol Sci. Sep 6;23(18):10256, 2022
207 Carli F, Tait S, Busani L, Ciociaro D, Della Latta V, Pala AP, Deodati A, Raffaelli A, Pratesi F, Conte R, Maranghi F, Tassinari R, Fabbrizi E, Toffol G, Cianfarani S, La Rocca C, Gastaldelli A, Life Persuaded Project Group.
Exposure to Endocrine Disruptors (Di(2-Ethylhexyl)phthalate (DEHP) and Bisphenol A (BPA)) in Women from Different Residing Areas in Italy: Data from the LIFE PERSUADED Project.
Int J Mol Sci. Dec 16;23(24):16012. 2022
208 Levi Mortera S, Marzano V, Vernocchi P, Matteoli MC, Guarrasi V, Gardini S, Del Chierico F, Rapini N, Deodati A, Fierabracci A, Cianfarani S, Putignani L
Functional and Taxonomic Traits of the Gut Microbiota in Type 1 Diabetes Children at the Onset: A Metaproteomic Study.
Int J Mol Sci. 2022 Dec 15;23(24):15982. 2022
209 Del Chierico F, Rapini N, Deodati A, Matteoli MC, Cianfarani S, Putignani L.
Pathophysiology of Type 1 Diabetes and Gut Microbiota Role
Int J Mol Sci. Nov 24;23(23):14650. 2022
210 Anita C. S. Hokken-Koelega, Manouk van der Steen, Margaret C. S. Boguszewski, Stefano Cianfarani,Jovanna Dahlgren, Reiko Horikawa, et al.
International Consensus Guideline on Small for Gestational Age: Etiology and Management From Infancy to Early Adulthood.
Endocrine Reviews, 2023, 00, 1–27 https://doi.org/10.1210/endrev/bnad002
211 Pezzino G, Ruta R, Rapini N, Chiodo DC, Mucciolo M, Tomaselli L, Cianfarani S, Barbetti F.
A rare cause of transient neonatal diabetes mellitus: Spontaneous HNF1B splice variant.
Diabet Med. 2024 Feb;41(2):e15202. doi: 10.1111/dme.15202.
212 Mosca A, Manco M, Braghini MR, Cianfarani S, Maggiore G, Alisi A, Vania A.
Environment, Endocrine Disruptors, and Fatty Liver Disease Associated with Metabolic Dysfunction (MASLD).
Metabolites. 2024 Jan 22;14(1):71. doi: 10.3390/metabo14010071.
213 Ravà L, Fintini D, Mariani M, Deodati A, Inzaghi E, Pedicelli S, Bizzarri C, Cappa M, Cianfarani S, Manco M.
High 1-h glucose in youths with obesity as marker of prediabetes and cardiovascular risk.
J Endocrinol Invest. 2023 Dec;46(12):2555-2562. doi: 10.1007/s40618-023-02111-6.
214 Aureli A, Recupero R, Mariani M, Manco M, Carlomagno F, Bocchini S, Nicodemo M, Marchili MR, Cianfarani S, Cappa M, Fintini D.
Low Levels of Serum Total Vitamin B12 Are Associated with Worse Metabolic Phenotype in a Large Population of Children, Adolescents and Young Adults, from Underweight to Severe Obesity.
Int J Mol Sci. 2023 Nov 22;24(23):16588. doi: 10.3390/ijms242316588
215 Deodati A, Bottaro G, Germani D, Carli F, Tait S, Busani L, Della Latta V, Pala AP, Maranghi F, Tassinari R, Gastaldelli A, La Rocca C, Cianfarani S.
Urinary Bisphenol-A (BPA) and Bis(2-ethylhexyl)phthalate (DEHP) metabolite concentrations in children with obesity: A case-control study. LIFE PERSUADED Project Group.
Horm Res Paediatr. 2023 Nov 16. doi: 10.1159/000535305.
216 Franceschi R, Fintini D, Ravà L, Mariani M, Aureli A, Inzaghi E, Pedicelli S, Deodati A, Bizzarri C, Cappa M, Cianfarani S, Manco M.
Insulin Clearance at the Pubertal Transition in Youth with Obesity and Steatosis Liver Disease.
Int J Mol Sci. 2023 Oct 6;24(19):14963. doi: 10.3390/ijms241914963.
217 Amodio D, Pascucci GR, Cotugno N, Rossetti C, Manno EC, Pighi C, Morrocchi E, D'Alessandro A, Perrone MA, Valentini A, Franceschini A, Chinali M, Deodati A, Azzari C, Rossi P, Cianfarani S, Andreani M, Porzio O, Palma P.
Similarities and differences between myocarditis following COVID-19 mRNA vaccine and multiple inflammatory syndrome with cardiac involvement in children.
Clin Immunol. 2023 Oct;255:109751. doi: 10.1016/j.clim.2023.109751
218 Troncone A, Affuso G, Cascella C, Chianese A, Zanfardino A, Iafusco D; Diabetes Study Group of Italian Society of Paediatric Endocrinology and Diabetology.
Prevalence and Multidimensional Model of Disordered Eating in Youths With Type 1 Diabetes: Results From a Nationwide Population-Based Study.
J Pediatr Psychol. 2023 Sep 20;48(9):731-739. doi: 10.1093/jpepsy/jsad016
219 Suomi T, Starskaia I, Kalim UU, Rasool O, Jaakkola MK, Grönroos T, Välikangas T, Brorsson C, Mazzoni G, Bruggraber S, Overbergh L, Dunger D, Peakman M, Chmura P, Brunak S, Schulte AM, Mathieu C, Knip M, Lahesmaa R, Elo LL; INNODIA Consortium.
Gene expression signature predicts rate of type 1 diabetes progression.
EBioMedicine. 2023 Jun;92:104625. doi: 10.1016/j.ebiom.2023.104625
220 Cianfarani S, Battelino T.
A critical review of upcoming new therapeutic options in paediatric endocrinology.
Horm Res Paediatr. 2023 Apr 24. doi: 10.1159/000530824.
221 Rapini N, Delvecchio M, Mucciolo M, Ruta R, Rabbone I, Cherubini V, Zucchini S, Cianfarani S, Prandi E, Schiaffini R, Bizzarri C, Piccini B, Maltoni G, Predieri B, Minuto N, Di Paola R, Giordano M, Tinto N, Grasso V, Russo L, Tiberi V, Scaramuzza A, Frontino G, Maggio MC, Musolino G, Piccinno E, Tinti D, Carrera P, Mozzillo E, Cappa M, Iafusco D, Bonfanti R, Novelli A, Barbetti F; Diabetes Study Group of Italian Society for Pediatric Endocrinology and Diabetes (ISPED).
The changing landscape of neonatal diabetes mellitus in Italy between 2003-2022.
J Clin Endocrinol Metab Feb 26:dgae095. doi: 10.1210/clinem/dgae095, 2024.
222 Hendriks AEJ, Marcovecchio ML, Besser REJ, Bonifacio E, Casteels K, Elding Larsson H, Gemulla G, Lundgren M, Kordonouri O, Mallone R, Pociot F, Szypowska A, Toppari J, Berge TVD, Ziegler AG, Mathieu C, Achenbach P; INNODIA consortium, the Fr1da Study Group and the GPPAD Study Group.
Clinical care advice for monitoring of islet autoantibody positive individuals with presymptomatic type 1 diabetes.
Diabetes Metab Res Rev. Feb;40(2):e3777. doi: 10.1002/dmrr.3777, 2024.
223 Rapini N, Martino M, Arnaldi C, Deodati A, Anagnostopoulou L, Amodeo ME, Ciampalini P, Pampanini V, Lorubbio A, Tosini D, Cianfarani S, Schiaffini R.
Efficacy and safety of advanced hybrid closed loop systems in children with type 1 diabetes younger than 6 years.
Front Endocrinol (Lausanne). May 21:15:1382920, 2024
224 Schiaffini R, Lumaca A, Martino M, Rapini N, Deodati A, Amodeo ME, Ciampalini P, Matteoli MC, Pampanini V, Cianfarani S.
Time In Tight Range in children and adolescents with type 1 diabetes: A cross-sectional observational single centre study evaluating efficacy of new advanced technologies.
Diabetes Metab Res Rev. Jul;40(5):e3826. 2024.
Letters
1. Cianfarani S., Spadoni G.L., Manca Bitti M.L., Boscherini B.
Growth hormone treatment and somatomedin C levels.
Journal of Pediatrics 105, 853, 1984.
2. Scirè G., Cianfarani S., Spadoni G.L., Manca Bitti M.L., Fonte M.T., Boscherini B., Pasquino A.M., Bozzao L.
Primary empty sella and endocrinopathies in childhood: high prevalence among children with precocious puberty.
European Journal of Pediatrics 147, 665, 1988.
3. Spadoni GL, Cianfarani S, Bernardini S, Vaccaro F, Galasso C, Boscherini B. How far should indications for growth hormone expand?
Lancet 335, 1351, 1990.
4. Scirè G, Magliocca FM, Cianfarani S, Scalamandrè A, Petrozza Bonamico M. Autoimmune polyendocrine candidiasis syndrome with associated chronic diarrhea caused by intestinal infection and pancreas insufficiency.
Journal of Pediatric Gastroenterology and Nutrition 13, 224-227, 1991.
5. Cianfarani S.
Growth hormone therapy in Noonan syndrome.
Journal of Pediatrics 134, 385-6, 1999.
6. Cianfarani S.
Ambras syndrome or hypertrichosis universalis, does it really matter?
Clinical Genetics 57, 158, 2000.
7. Cianfarani S, Bonfanti R, Manca Bitti ML, Chiumello G, Boscherini B.
Growth and autoantibodies to IA-2 in children with type 1 diabetes.
Lancet 356, 1521, 2000.
8. Cianfarani S.
Role of Hormones in Puberty
Lancet 358, 1459, 2001.
9. Schiaffini R, Deodati A, Rapini N, Pampanini V, Cianfarani S.
Increased incidence of childhood type 1 diabetes during the COVID-19 pandemic. Figures from an Italian tertiary care center.
Journal of Diabetes. 2022 Aug;14(8):562-563.
Testi e Monografie
Boscherini B., Cianfarani S., Spadoni G.L., Mancuso G.
Il bambino con bassa statura.
Ed: Piccin, Padova, 1990.
Cianfarani S. Bambini Nati Piccoli per Età Gestazionale (small for gestational age, SGA): Implicazioni Cliniche. Come, Quando e Perchè Trattarli con l’Ormone della Crescita. Ed: Mediprint, Roma, 2007.
Capitoli di testi
C1 Boscherini B., Spadoni G.L., Cianfarani S. Le anomalie della crescita: eziologia e classificazione. In: Progressi nella Diagnosi e Terapia dei Disturbi dell'Accrescimento. A cura di E.E. Muller & G. Chiumello. Pythagora Press, Milano, pp. 175-197, 1987.
C2 Cianfarani S, Spadoni GL. La bassa statura (Short
Stature). In: Endocrinologia Pediatrica (Paediatric
Endocrinology). Boscherini B. & Scalamandre' A. Ed.
Nuova Scientifica Italiana, Roma, pp. 13-47, 1991.
C3 Cianfarani S. Gli ormoni: Azione degli ormoni e loro
dosaggio. In: Diagnosi e Terapia in Endocrinologia.
GL Spadoni, AP Taviani, V Toscano. Ed. Grasso, Bologna, 1993, pp.1-15.
C4 Cianfarani S. Disturbi della Crescita (Growth Disorders). In: Dal Sintomo alla Diagnosi in Endocrinologia Pediatrica (From Symptoms to Diagnosis in Pediatric Endocrinology). B. Boscherini, GL Spadoni, S. Stoduto. Carocci Editore, Roma, 2003.
C5 Cianfarani S. Tumori Associati ad Endocrinopatie (Tumors associated to Endocrinopaties).
In: Dal Sintomo alla Diagnosi in Endocrinologia Pediatrica (From Symptoms to Diagnosis in Pediatric Endocrinology). B. Boscherini, GL Spadoni, S. Stoduto.
Carocci Editore, Roma, 2003.
C6 Giacomozzi C and Cianfarani S. Patologie dell’ipofisi anteriore. Deficit di GH. “Hypopituitarism: GH deficiency”. Capitolo 73, pp. 659-669. Vademecum di Diagnosi e Terapia Pediatrica, Margiacchi-Galeno Editrice, Perugia 2008.
C7 Giacomozzi C and Cianfarani S. Diabete insipido e sindrome da inappropriata secrezione di ormone antidiurerico “Diabetes insipidus and sindrome of inappropriate antidiuretic hormone (SIADH)”. Capitolo 74, pp. 669-679. Vademecum di Diagnosi e Terapia Pediatrica, Margiacchi-Galeno Editrice, Perugia 2008.
C8 Cianfarani S. Neuroendocrine Complications of Central Nervous System Malformations. Chapter 23. In: Maformations of the Nervous System, Handbook of Clinical neurology, 3rd Edition. Eds: H.B. Sarnat, P. Curatolo. Elsevier Ltd., pp 433- 458, 2008.
C9 Cianfarani S. Growth and growth factors. In: Yearbok of Pediatric Endocrinology. Eds: Carel JC and Hochberg. Z. Karger AG, Basel, Switzerland, 2010, pp 49-64.
C10 Pedicelli S, Scirè G, Bertelloni S, Peschiaroli E, Deodati A, Garofalo P e Cianfarani S. Il deficit di ormone della crescita nel periodo di transizione. Adolescentologia Aspetti Medici e Socio-Educativi, cap. 6, pp 57-62, 2010
C11 Cianfarani S. Growth and growth factors. In: Yearbok of Pediatric Endocrinology. Eds: Carel JC and Hochberg. Z. Karger AG, Basel, Switzerland, 2011, pp 47-61.
C12 Cianfarani S. Growth and growth factors. In: Yearbook of Pediatric Endocrinology. Eds: Ong K and Hochberg. Z. Karger AG, Basel, Switzerland, 2012, p. 45-59.
C13 Cianfarani S. Growth and growth factors. In: Yearbook of Pediatric Endocrinology. Eds: Ong K and Hochberg. Z. Karger AG, Basel, Switzerland, 2013, P. 45-60.
C14 Inzaghi E and Cianfarani S. Growth and growth factors. In: Yearbook of Pediatric Endocrinology. Eds: Ong K and Hochberg. Z. Karger AG, Basel, Switzerland, 2014, P. 45-61.
C15 Inzaghi E and Cianfarani S. Growth and growth factors. In: Yearbook of Pediatric Endocrinology. Eds: Ong K and Hochberg. Z. Karger AG Haymarket, Teddington, UK, 2015, P. 40-59
C16 Inzaghi E and Cianfarani S. Growth and growth factors. In: Yearbook of Pediatric Endocrinology. Eds: Ong K and Hochberg. Z. Haymarket, Teddington, UK, 2016, P. 49-64.
C17 Inzaghi E and Cianfarani S. Growth and growth factors. In: Yearbook of Pediatric Endocrinology. Eds: Ong K and Hochberg. Z. Haymarket, Teddington, UK, 2017, P. 50-67.
ATTIVITA' EDITORIALE
Boscherini B., Cianfarani S., Spadoni G.L. Eds.
Binding proteins for growth hormone and somatomedins.
Acta Endocrinologica, Vol. 124, Supplement 2, 1991.
Cianfarani S, Clemmons DR, Savage MO (eds.). IGF-I and IGF binding proteins. Basic research and clinical
CURRICULUM VITAE ET STUDIORUM E PUBBLICAZIONI DEL PROF. STEFANO CIANFARANI 19.6.2024 “… Noi non cerchiamo quello che Iddio poteva fare, ma quello che Egli ha fatto…poi finalmente sollevandoci all’ultimo scopo delle nostre fatiche, cioè all’amore del Divino Artefice, ci conservino la speranza di poter apprendere in Lui, fonte di luce e di verità ogni altro vero.” (Galileo Galilei) Stefano Cianfarani Nome: Stefano Cianfarani Indirizzo Università: Clinica Pediatrica-Dipartimento di Medicina dei Sistemi, Università degli Studi di Roma “Tor Vergata”, Via Montpellier 1, 00133-Roma Tel: 06-6859 3074 (Osp.) Tel: 06-7259 6178 (Lab.) Fax: 06-6859 2508 Indirizzo casa: Via Città di Castello 35, 00191 - Roma Tel: 06- 33 30 813 E-Mail: stefano.cianfarani@uniroma2.it Codice Fiscale: CNFSFN57T20H501C Data di nascita: 20 Dicembre 1957 Luogo di nascita: Roma Nazionalità: Italiana Stato Civile: Sposato con Teresa Maria Martino. Padre di Francesco, Eugenia, Agnese, Bernardo, Bartolomeo e Giovanni Maria Scolarità: Diploma di Maturità (60/60) presso il Liceo Classico della Scuola Pontificia Scuola "Pio IX" nel 1976. Facoltà di Medicina e Chirurgia: Universita' degli Studi di Roma "La Sapienza" 1976-1982. Voto di Laurea 110/110 con Lode Scuola di Specializzazione: Pediatria, Universita' degli Studi di Roma "La Sapienza" 1982-1986. Voto diploma di Specializzazione 70/70 con Lode. Attuale posizione : Professore Ordinario di Pediatria Generale e Specialistica (MED/38). Dipartimento Medicina dei Sistemi, Facoltà di Medicina e Chirurgia dell’Università di Roma Tor Vergata, Roma. Responsabile della Unità Operativa Complessa (U.O.C.) di “Endocrinologia e Diabetologia”, presso Ospedale Pediatrico I.R.C.C.S. Bambino Gesù, Roma. Dal 1/11/2012 Visiting Professor presso il Department of Women´s and Children´s Health, al Karolinska Institute, Stoccolma, Svezia. Attualmente: Affiliated Researcher presso il Department of Women´s and Children´s Health, al Karolinska Institute, Stoccolma, Svezia. Referente dell’Unità di Ricerca “Fisiopatologia della Crescita”, Ospedale Pediatrico “Bambino Gesù”, Roma. Chair of Clinical Practice Committee della European Society fo Pediatric Endocrinology (ESPE), 2022-2025. Posizioni Precedenti: Professore Associato di Pediatria Generale e Specialistica (MED/38), Facoltà di Medicina e Chirurgia, Università degli Studi di Roma Tor Vergata. Dal 1.11.2002 al 27/2/2018 Responsabile della Unità Operativa Complessa (U.O.C.) di “Diabetologia e Patologia dell’Accrescimento”, presso Ospedale Pediatrico I.R.C.C.S. Bambino Gesù, Roma. Dal 2017 al 2018 Responsabile della Struttura Semplice Dipartimentale di “Diabetologia”, presso Ospedale Pediatrico I.R.C.C.S. Bambino Gesù, Roma. Dal 1/10/2009 al 15/5/2017 Responsabile Struttura Semplice di “Endocrinologia Molecolare” presso Ospedale Pediatrico I.R.C.C.S. Bambino Gesù, Roma. Dal 1/7/1988, Funzionario Tecnico, Clinica Pediatrica, Dipartimento di Sanità Pubblica e Biologia Cellulare, Università degli Studi di Roma, "Tor Vergata", Roma. Dal 25/11/1988, Dirigente I livello (Assistente Ospedaliero) presso la Divisione di Pediatria, Ospedale S. Eugenio, Azienda USL RM-C, Roma. Dal 24/3/2003 Dirigente I Livello (ex Aiuto Ospedaliero) presso la Divisione di Pediatria (U. Org. Patologi Endocrina Pediatrica), Ospedale S. Eugenio, Azienda USL RM-C, Roma. Dal 1995, Responsabile del Laboratorio di Endocrinologia Pediatrica, Università “Tor Vergata”, Roma Dal 24/03/2003 al 30/09/2009 Responsabile dell’Unità Organizzativa di Patologia Endocrina Pediatrica, Ospedale S.Eugenio, ASL RM-C, Roma. Dal 1/1/2009 al 31/8/2009 incaricato dal Rettore dell’Università di Roma “Tor Vergata” come Direttore della Clinica Pediatrica dell’Università di Roma “Tor Vergata” con sede presso l’Ospedale S.Eugenio Roma. Presidente Società Italiana di Endocrinologia e Diabetologia Pediatrica (SIEDP) per il biennio 2017-2019. Presidente European Society fo Pediatric Endocrinology (ESPE) 2022. Tipologia Prestazioni Assistenziali: -Dalla data di strutturazione (1988):Assistenza diurna, notturna e festiva presso U.O.C. di Pediatria presso Ospedale S. Eugenio Roma, ASL-RMC, in convenzione con Università degli Studi di Roma Tor Vergata, con compiti di responsabilità diretta, con turni periodici di corresponsabilità del Reparto. Consulenze diurne, notturne e festive presso la Accettazione e il Pronto Soccorso dell’Ospedale S. Eugenio, Azienda USL RM-C, Roma, con compiti di responsabilità diretta. -Delegato periodicamente dal Primario della U.O.C. di Pediatria a sostituirlo come responsabile della stessa U.O.C. di Pediatria presso Ospedale S. Eugenio Roma, ASL-RMC, in convenzione con Università degli Studi di Roma Tor Vergata. -Attività ambulatoriale specialistica in Patologia Endocrina Pediatrica e responsabile della Unità Organizzativa di Patologia Endocrina Pediatrica-B2 su delibera del Consiglio di Facoltà del 24/10/2002 ed in conformità con quanto stabilito dalla ASL RMC in data 23/1/2002 delibera n. 42. -Incaricato dal Rettore dell’Università di Roma Tor Vergata ad esercitare funzione primariale temporanea presso la U.O.C. di Pediatria-Oncoematologia Pediatrica presso l’Ospedale S. Eugenio dal decorrenza dal 1.12.2008. Attività Didattica Insegnamenti: Corso di Laurea in Medicina 2002-2012 Corso Integrato di Pediatria (Scienze Pediatriche) Scuola di Specializzazione in Pediatria: 1989-1991 Clinica Pediatrica 1991-1993 Pediatria Generale e Specialistica 1993-1996 Endocrinologia 1999-2000 Pediatria Generale 2001-2004 Endocrinologia Pediatrica e Malattie del Metabolismo Infantile e Neonatale 2002-2003 Patologia Clinica 2003-2006 Endocrinologia Pediatrica 2004-2005 Pediatria Generale e Specialistica 2007-2012 Pediatria Generale e Specialistica Scuola di Specializzazione Scienze dell’Alimentazione: 2000/2001, 2003/2004, 2005-2008 Pediatria Scuola di Specializzazione in Neuropsichiatria Infantile 2005-2008 Neuropsicoendocrinologia Scuola di Specializzazione in Ortopedia e Traumatologia 2009 PediatrIa Diploma Universitario in Dietologia e Dietetica Applicata 1995-1997 Patologia dell’età evolutiva Diploma Universitario in Dietista 1997-2001 Patologia dell’età evolutiva Diploma Universitario in Ostetricia 1997-1998 Cardiologia Pediatrica Diploma Universitario Tecnici in Riabilitazione Psichiatria 2010 Pediatria Dottorato di Ricerca in Pediatria Molecolare, Università Tor Vergata, Roma. Docente AA.AA. 2002-2006. Scuola di Alta Formazione in Pediatria, Università Tor Vergata/Ospedale Pediatrico Bambino Gesù, Roma. 2012 Comitato Scientifico Master in Endocrinologia Pediatrica, Università di Parma AA 2010 e 2012 Basse stature da alterazione periferica Docente e organizzatore Corso di Perfezionamento in Endocrinologia Pediatrica, Università Tor Vergata, Roma, 10/3-9/6, 1999-2000. Docente e coordinatore Corso di Perfezionamento in Endocrinologia Pediatrica, Università Tor Vergata, Roma, 2000-2001. Docente Winter School, European Society for Paediatric Endocrinology, Varna, Bulgaria, 4-11 marzo 2006. Master Direttore Master II livello in Endocrinologia e Diabetologia Pediatrica, Scuola di Alta Fromazione in Pediatria, Università degli Studi di Roma Tor Vergata e Ospedale Pediatrico Bambino gesù, Roma. Primo ciclo a partire dal 2014. PhD courses (Dottorato di ricerca) Docente del Corso di Dottorato in Pediatria Molecolare Università degli Studi di Roma Tor Vergata (2003-2004). Docente del Corso di Dottorato in Pediatria Molecolare e Biotecnologie Applicate, Università degli Studi di Roma Tor Vergata (2005). Docente del Corso di Dottorato in "Immunologia, medicina molecolare e biotecnologie applicate ( ex immunologia e biotecnologie applicate)" Università degli Studi di Roma Tor Vergata (2012-2016). Docente del Corso di Dottorato in "Immunologia, medicina molecolare e biotecnologie applicate ( ex immunologia e biotecnologie applicate)" Università degli Studi di Roma Tor Vergata (2012-2017). Tutor and Supervisor: Supervisore della Dr.ssa Caterina Geremia, PhD, with the Thesis: “Metabolic programming in intrauterine groath retardsation (IUGR). Results from clinical and laboratory investigations”. Tor Vergata University, Rome, 2007. Supervisore della Dr.ssa Arianna Maiorana, PhD, with the Thesis: “A Method to Isolate Omental Adipose Stem cells in Pediatric Patients: Perspectives in investigating the Pathogenesis of metabolic Syndrome”. Tor Vergata University, Rome, 2008 Official opponent in doctoral dissertation of PhD. Candidate Sirpa Tenhola, Thesis Title: Cardiovascular Risk Factors and Adrenal Function in 12-year-old Children Born Small for Gestational age or After a Preeclamptic Pregnancy, University of Kuopio, Finland, 2006. Supervisore della Dr.ssa Valentina Pampanini, PhD Course, Women's and Children's Health, Pediatric Endocrinology Unit, Karolinska Institute, Stoccolma Sweden. Official opponent in doctoral dissertation of PhD. Candidate Manouk van der Steen, Thesis Title: Growth hormone treatment in SGA. More than meet the eye. Erasmus University, Rotterdam, 2016. Official opponent in doctoral dissertation of PhD. Candidate Carolina Smeets, Thesis Title: “Silver-Russell Syndrome & Small for Gestational Age Long-term health perspectives” Erasmus University, Rotterdam, 2017. External reviewer in doctoral dissertation of PhD. Candidate Nicola Improda, Thesis title: “New insights in childhood-onset growth hormone deficiency: from diagnosis to long-term outcomes”. Clinical and Experimental Medicine, University of Naples Federico II, Naples, 2021. Official opponent in doctoral dissertation of PhD. Candidate Wesley J. Goedegebuure, Thesis Title: “Small for gestational age. Adult metabolic and cardiovascular health and long-term safety of growth hormone treatment”. Erasmus University, Rotterdam, 2021. Società di appartenenza: Ordine dei Medici della Provincia di Roma N. 32942 (10/2/1983) British General Medical Council Registration N. 3417762 (13/5/1991) • Società Italiana di Pediatria • Società Italiana di Endocrinologia e Diabetologia Pediatrica • European Society for Pediatric Endocrinology (ESPE) Incarichi Internazionali Chairman of the Clinical Practice Committee della European Society for Pediatric Endocrinology dal 2004 al 2010. Comitato scientifico della Consensus Conference internazionale sull’approccio diagnostico e terapeutic del bambino nato piccolo per età gestazionale. Un Simposio internazionale organizzato congiuntamente dalla European Society for Pediatric Endocrinology (ESPE), Lawson Wilkins Society for Pediatric Endocrinology (LWPES) and la Growth Hormone Research Society (GRS). Manchester, UK, 2006 Membro del Consiglio Direttivo della European Society for Pediatric Endocrinology 2004-2010. Membro del Programme Organizing Committee della European Society for Pediatric Endocrinology 2004-2010. Consulente temporaneo Organizzazione Mondiale della Sanità (OMS). 2006. Membro temporaneo dell’EMA Scientific Advisory Group (SAG) for Diabetes/Endocrinology dal 2007. Membro Advisory Group della ERA-NET PRIOMEDCHILD European Network for Medicines in Childhood. 2008. Comitato scientifico organizzatore della Consensus Conference internazionale Growth Hormone Safety Workshop Workshop internazionale organizzato congiuntamente dalla European Society for Pediatric Endocrinology (ESPE), Pediatric Endocrinology Society (PES) and Growth Hormone Research Society (GRS). Manchester, UK, November, 2014. Chair of the Board of Advanced Seminars in Developmental Endocrinology (2014-2016), European Society for Pediatric Endocrinology (ESPE) Dal 2015 al 2019, membro del pannello di esperti del Science Committee della European Society for Pediatric Endocrinology (ESPE). Premi Internazionali Nomination per il Research Award della European Society for Pediatric Endocrinology (2005, 2006, 2007). Comitati e Consulenze Scientifiche: Comitato scientifico, V Congresso della Società Italiana di Endocrinologia e Diabetologia Pediatrica (SIEDP). Roma 18- 19 Ottobre 1985. Scientific Secretary, International Workshop on Binding Proteins for Growth Hormone and Somatomedins, Roma, November 23-24, 1990. Consulente scientifico per la R.A.I. per trasmissioni sulla crescita e la pubertà (D.S.E.) 1985 e 1986. Comitato Scientifico, Corso SIEDP in Endocrinologia Pediatrica, Sabaudia 5-7 Ottobre 2000. Coordinatore Corso di Perfezionamento in Endocrinologia Pediatrica, Università di Tor Vergata, Roma, 2002. Coordinatore Gruppo di Studio su “Fisiopatologia dei processi di accrescimento” Società Italiana di Endocrinologia e Diabetologia Pediatrica (SIEDP), 2001-2003 Comitato scientifico dell’Accademia Nazionale di Medicina, coordinatore per il settore Endocrinologia e Malattie del Ricambio dell’Età Evolutiva (2005-2008). Responsabile commissione giovani Società Italiana di Endocrinologia e Diabetologia Pediatrica (SIEDP) 2007-2009 Responsabile commissione farmaci Società Italiana di Medicina dell’Adolescenza (SIMA) 2009-2011. Membro Comitato Scientifico Fondazione “Cesare Serono”, dal 2011. Membro Gruppo di Lavoro Ricerca e Sviluppo, Agenzia Italiana del Farmaco (AIFA) 2011-2012. Member of the Steering Committee, European Society for Pediatric Endocrinology (ESPE) Advanced Seminar in Developmental Endocrinology (From 2012). Borse di Studio: C.N.R. borsa di studio per l'estero (n.203.04.10 6/5/1986) per il progetto: "Western Blotting Technique in the study of short stature" (1986). Department of Chemical Endocrinology, St. Bartholomew's Hospital, Londra, Gran Bretagna C.N.R.-N.A.T.O. junior fellowship (n. 215.24 18/01/90) per il progetto: "Insulin-like growth factor binding proteins in children with short stature" (1990). Division of Pediatric Endocrinology, St. Bartholomew's Hospital, Londra, Gran Bretagna. C.N.R.-N.A.T.O. senior fellowship (n. 217.28 del 29/4/1995) per il progetto: "Effetto dell’ormone della crescita e dei fattori di crescita insulino-simili (IGFs) sulla stabilità del genoma umano: studio “in vitro” e “in vivo”. University of Bristol, Bristol, Gran Bretagna. Precedenti Posizioni scientifiche e professionali all’estero: Visiting Paediatrician, Department of Growth and Development, (Prof. J.M. Tanner) Institute of Child Health, University of London, U.K. Settembre 1984 Visiting Researcher, Laboratory of Tumor Cell Biology, (Dr. R.C. Gallo), National Institutes of Health, National Cancer Institute, Bethesda, Maryland, U.S.A. Da Agosto a Settembre 1985 Research Fellow in Endocrinology (Prof. L.H. Rees), Department of Chemical Endocrinology, St. Bartholomew's Hospital, London U.K. Da Settembre 1988 a Febbraio 1989 Research Fellow in Paediatric Endocrinology, Division of Paediatric Endocrinology, Department of Endocrinology, St. Bartholomew's Hospital, London EC1A 7BE Da Maggio 1991 ad Aprile 1992 Honorary Clinical Assistant in Paediatric Endocrinology, Department of Paediatric Endocrinology, Dr. Martin Savage, "The Queen Elizabeth Hospital for Children", London, E2 8PS Da Maggio 1991 ad Aprile 1992 Teacher of Endocrinology of Growth, Serono, Auxology Course, St. Bartholomew's Hospital, London EC1A 7BE. 1991-1992 Honorary Research Fellow in Pediatric Endocrinology, Royal Hospital for Sick Children, Bristol BS2 8BJ, dal 28 Ottobre 1996 per 2 anni. Visiting Fellow in Surgery, Bristol Royal Infirmary, University of Bristol, Bristol BS2 8BJ, U.K. dal 30 Novembre 1996 per due anni. Organizzazione Conferenze Internazionali: Organizer and member of the Steering Committee. International Conference Organization Workshop on Binding Proteins for Growth Hormone and Somatomedins. Rome, November 23-24, 1990. Organizer and member of the Steering Committee. IGF-I and IGF binding protein assessment and therapeutic benefit. Serono Symposia, New Orleans, June 14-15, 2004. Organizer and member of the Steering Committee. ESPE/GRS/LWPES Consensus Workshop on Management of the Small for Gestational Age Child. 1-4 February 2006 Manchester, UK Delegate to ESPE/GRS/LWPES Consensus Workshop on Idiopathic Short Stature. 17-20 October 2007, Los Angeles, CA, US Comitato scientifico organizzatore della Consensus Conference internazionale Growth Hormone Safety Workshop Workshop internazionale organizzato congiuntamente dalla European Society for Pediatric Endocrinology (ESPE), Pediatric Endocrinology Society (PES) and Growth Hormone Research Society (GRS). Manchester, UK, November, 2014. Editorial Board 1. Editor in Chief, Frontiers in Pediatric Endocrinology, Frontiers Research Foundation, Lausanne, Switzerland, fino a Gennaio 2014 2. Associate Editor of Review of Diabetic Studies, Society for Biomedical Diabetes Research. Fino a Gennaio 2014. 3. Editor in Chief (appointed from 2014), Hormone Research in Paediatrics, Karger, Basel, Switzerland. 4. Advisory Board member of Biomedicine Hub, Karger, Basel, Switzerland. Dal 2016 5. Editorial board: Annals of Pediatric Endocrinology and Metabolism, dal 2016. 6. Editorial board: Jornal de Pediatria, Brazil, dal 2021 Incarichi Accademici Internazionali Official opponent in doctoral dissertation of PhD. Candidate Sirpa Tenhola, Thesis Title: Cardiovascular Risk Factors and Adrenal Function in 12-year-old Children Born Small for Gestational age or After a Preeclamptic Pregnancy, University of Kuopio, Finland, May 27th, 2006. Teacher of Evidence-Based Medicine in Paediatric Endocrinology, at the “Advanced Postgraduate Course on Methods in Growth Research – Theory and Practice”. Karolinska Institutet, Stockholm, November 22-26, 2010. Supervisore della Dr.ssa Valentina Pampanini, PhD Course, Women's and Children's Health, Pediatric Endocrinology Unit, Karolinska Institute, Stoccolma Sweden. Official opponent in doctoral dissertation of PhD. Candidate Manouk van der Steen, Thesis Title: Growth hormone treatment in SGA. More than meet the eye. Erasmus University, Rotterdam, 2016. Reviewer per: • Acta Paediatrica • Acta Obstetrica and Gynaecologica Scandinavica • Americal Journal of Clinical Nutrition • Archives for Diseases in Childhood • BMC Medical Genetics • Clinical Endocrinology • Diabetes • Diabetologia • Dutch Diabetes Research Foundation • Endocrinology • European Society for Pediatric Endocrinology • European Journal of Endocrinology • Frontiers in Pediatric Endocrinology • Hormone Research • International Journal of Cancer • International Journal of Clinical Practice • International Journal of Obesity • Italian Ministry of University and Research (MIUR). National Research Programmes (PRIN). • Journal of Clinical Endocrinology and Metabolism • Journal of Endocrinological Investigation • Journal of Pediatric Endocrinology and Metabolism • Journal of Pediatrics • Lancet • Metabolism • Obesity • Pediatric Research • Pediatrics • Psychoneuroendocrinology • Review of Diabetic Studies • Swiss National Science Foundation • Trends in Endocrinology and Metabolism • European Commission – HORIZON 2020 Direzione Attività Formativa ECM Responsabile Evento Formativo Tavola Rotonda: Prevenzione dell’Osteoporosi dell’Adulto in Età Pediatrica. Roma 6-9.2003. Crediti ECM assegnati: n. 3 Responsabile Evento Formativo Corso di Aggiornamento: Errori in Endocrinologia Pediatrica. Roma 18-10.2003. Crediti ECM assegnati: n. 6 Responsabile Evento Formativo: Corso di Aggiornamento in Endocrinologia Pediatrica, “Terapia Endocrina nell’Età Evolutiva”. Roma, Marzo-Giugno, 2004. Crediti ECM assegnati: n. 23 Responsabile Evento Formativo con US CME: “IGF-I and IGF binding protein assessment and therapeutic benefit”. New Orleans 14-15 Giugno, 2004, Serono Symposia. Responsabile Evento Formativo: Corso di Aggiornamento in Endocrinologia Pediatrica, “Endocrinologia pediatrica per problemi”. Roma, Marzo-Giugno, 2006. Crediti ECM assegnati: n. 17 Responsabile evento formativo: Corso di Aggiornamento in Endocrinologia Pediatrica, “Clinical Practice in Endocrinologia Pediatrica” Roma, Marzo-Giugno, 2008. crediti ECM: 19 Responsabile evento formativo: Corso di aggiornamento, “SGA: cause e conseguenze del basso peso alla nascita”. Roma, 21 Giugno, 2008. crediti ECM: 6 Attività formativa Coordinatore del Corso di Endocrinologia Pediatrica, per paesi in via di sviluppo per conto della Società Europea di Endocrinologia Pediatrica (ESPE). Nairobi (Kenia) 16-20 Maggio, 2006. Research Grants Gestiti come Responsabile “The Prevention of osteoporosis by nutrional phytoestrogens (PHYTOS)”. Shared Cost RTD actions. European Commission. Anno 1999, durata 48 mesi, Proposal No. QLRT-1999-00857. Subcontractor of Contractor 1: Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione. “Deteminazione di IGF-I, IGFBP-3, IGFBP-4 e forme circolanti di IGFBP-3”. Importo finanziato pari a 45.000 EURO. Principal Investigator and Coordinator “Terapia sperimentale nell’adrenoleucodistrofia”. Fondazione Baroni. Anno 2000-2001. Importo finanziato pari a Lire 50.000.000 “Phytohealth”. European Network for Research on Phytoestrogens. CORDIS RTD-Project #68987, EC 2003; 5000 EURO “S6 Kinase activity in Human Placentas from Normal and SGA Fetuses”. MIUR 60% 2003. 2500 EURO. Principal Investigator and Coordinator “Origine fetale delle malattie dell’adulto. Identificazione precoce dei fattori di rischio cardiovascolare e metabolico nei soggetti nati con ritardo di crescita ad inizio intrauterino”. MIUR COFIN-40% - 2003 . Coordinatore Nazionale del Progetto. Euro: 136.000. Responsabile Unità Operativa, Roma, Tor Vergata, EURO 63.000. Principal Investigator and Coordinator “Proteolisi della IGFBP-3 nei pazienti con deficit di GH (GHD). Effetto sulla sensibilità e specificità del dosaggio della IGFBP-3 nella diagnosi di GHD.” Progetti di Ricerca di Ateneo (ex 60%). Anno 2005. EURO 4.200. Principal Investigator and Coordinator Riprogrammazione dell’attività S6K e IRS-1 ed espressione dei recettori per insulina e IGF-I nei bambini small for gestational age (SGA). Progetti di Ricerca di Ateneo (ex 60%). Anno 2006. EURO 2.300. Principal Investigator and Coordinator “SAGhE: Safety and Appropriateness of Growth hormone treatments in Europe”. FP7-HEALTH-2007: Better use of medicines Collaborative projects (Small or medium-scale focused research projects) Coordinating person: Jean-Claude Carel EU grant FP7-223497, 2009-2012. Euro 440000 for the local Unit (Tor Vergata, University, Rome) coordinated by Prof. Stefano Cianfarani, Principal Investigator and Coordinator of WORKPACKAGE 4. “Protective role of IGF-I in premature babies at risk of neurological damage and retinopathy” Eli Lilly grant 2009. euro 70.000. Pricipal Investigator and Coordinator “Metilazione del gene igf2, ritardo di crescita ad inizio intrauterino e alterazioni metaboliche. Studio clinico in bambini obesi nati piccoli per età gestazionale e con peso alla nascita appropriato per età gestazionale.” Ricerca Corrente Ospedale Pediatrico Bambino Gesù, IRCCS, 2011. 12.000 Euro. Principal Investigator and Coordinator “Growth Hormone Treatment For Short Children Born Preterm And Presenting Extrauterine Growth Retardation”. Principal Investigator and Coordinator. Pfizer grant 2011. 164.000 Euro “Studio multicentrico europeo sulla identificazione dei fattori di rischio metabolico in bambini ed adolescenti obesi.” Ricerca Corrente Ospedale Pediatrico Bambino Gesù, IRCCS, 2012. 60.000 Euro. Principal Investigator and Coordinator Deficit Subclinico di Vitamina D e Rischio Metabolico e Cardiovascolare in Bambini Obesi. Trial Pilota Randomizzato Controllato con Vitamina D3. Ricerca Corrente Ospedale Pediatrico Bambino Gesù, IRCCS, 2013. 52000 Euro. Principal Investigator and Coordinator. miRNA – Novel markers to predict the development of obesity‐related disorders? Collaborative International Project. European Society for Paediatric Endocrinology-Research Unit. Co- Investigator. 2013. 60000 Euro. "PERSUADED. Phthalates and bisphenol : a biomonitoring in Italian mother-child pairs: link between exposure and juvenile diseases" LIFE13 ENV/IT/000482. Principal Investigator of “Bambino Gesù” Children’s Hospital Unit. Progetto cofinanziato Comunità Europea. Cofinanziamento richiesto 877658 Euro Principal Investigator of “Bambino Gesù” Children’s Hospital Unit. 238.853 Euro. Translational approaches to disease modifying therapy of type 1 diabetes - HARVESTing the fruits of INNODIA European Commission (BRUSSELS ) 2020-06 to 2023-06|Grant GRANT_NUMBER: 945268 Translational approaches to disease modifying therapy of type 1 diabetes: an innovative approach towards understanding and arresting type 1 diabetes - Sofia ref.: 11579 European Commission (Brussels) 2015-11-01 to 2022-10-31|Gran GRANT_NUMBER: 11579 URL:https://app.dimensions.ai/details/grant/grant.6814282 TESI Tesi di Laurea in Medicina e Chirurgia: "Patologia pediatrica da difetti recettoriali", 1982, Relatore Prof. B. Boscherini. Tesi di Diploma per la Specializzazione in Pediatria: "Nuovi metodi di indagine della funzionalità somatotropinica", 1986, Relatore Prof. B. Boscherini. PUBBLICAZIONI ORIGINAL ARTICLES 1. Spadoni G.L., Cianfarani S., Boscherini B. Le Somatomedine. Rivista Italiana di Pediatria 10, 347-351, 1984. 2. de Capoa A., Baldini A., Marlekaj P., Natoli C., Rocchi M., Archidiacono N., Cianfarani S., Spadoni G.L., Boscherini B. Hormone-modulated rRNA gene activity is visualized by selective silver staining of the NOs. Cell Biology International Reports 9, 791-796, 1985 3. de Capoa, Marlekaj P., Baldini A., Felli M.P., Rocchi M., Archidiacono N., Cianfarani S., Spadoni G.L., Boscherini B. Growth-hormone induced regulation of rRNA gene activity in human cultured cells. Hormone and Metabolic Research 18, 574-575, 1986. 4. Cianfarani S., Spadoni G.L., Finocchi G., Ravet P., Costa F., Papa M., Scirè G., Manca Bitti M.L., Boscherini B. Growth hormone treatment in Noonan's syndrome. Minerva Pediatrica 39, 281-284, 1987. 5. Cianfarani S., Spadoni G.L., Scirè G., Galasso C., Benvenuti S., Manca Bitti M.L., Rezza E., Boscherini B. Pretreatment growth velocity and response to GH (HGH) therapy. Minerva Pediatrica 39, 757-761, 1987. 6. Vaccaro F., Cioschi S., Falvo F., Bernardini S., Spadoni G.L., Cianfarani S., Carrozzo A.M., Nini G., Galasso C., Manca Bitti M.L., Pasquino A.M. Acanthosis Nigricans, insulino-resistenza ed endocrinopatie: attuali vedute e conoscenze. Il Progresso Medico 43, 483-489, 1987. 7. Spadoni G.L., Cianfarani S., Baldini A., Ravenna L., Felli M.P., Camaioni A., Manca Bitti M.L., Scirè G., Boscherini B., de Capoa A. Laron dwarfism: cellular unresponsiveness to GH demonstrated on cultured lymphocytes by a cytochemical method. Hormone and Metabolic Research, 20, 450-452, 1988. 8. Boscherini B., Cianfarani S., Spadoni G.L. Growth Disorders. Medicina 8, 287-292, 1988. 9. Baldini A., Felli M.P., Ravenna L., Camaioni A., de Capoa A., Spadoni G.L., Cianfarani S., Boscherini B. Differential ribosomal gene responsiveness to human growth hormone is visualized by selective silver staining. Cytogenetics and Cell Genetics 47, 22-25, 1988. 10. Spadoni G.L., Cianfarani S., Bernardini S., Vaccaro F., Galasso C., Manca Bitti M.L., Costa F., Boscherini B. Twelve-hour spontaneous nocturnal growth hormone secretion in growth retarded patients. Clinical Pediatrics 27, 473-478, 1988. 11. Holly JMP, Smith CP, Dunger DB, Howell RJS, Chard T, Perry LA, Savage MO, Cianfarani S., Rees LH, Wass JAH. Relationship between the pubertal fall in sex hormone- binding globulin and insulin-like growth factor binding protein-I. A synchronised approach to pubertal development? Clinical Endocrinology 31, 277-284, 1989. 12. Bernardini S., Cianfarani S., Galasso C., Spagnoli A., Vaccaro F., Spadoni G.L. Somatotropin function in Noonan's syndrome. Pediatria Oggi 9, 110-112, 1989. 13. Spagnoli A., Bernardini S., Galasso C., Vaccaro F., Manca Bitti M.L., Scirè G., Cianfarani S., Spadoni G.L. Treatment of somatotropic deficiency with biosynthetic growth hormone. Medical and Surgical Pediatrics 11, 5-10, 1989. 14. Cianfarani S., Holly JMP Somatomedin-binding proteins: what role do they play in the growth process? European Journal of Pediatrics 149:76-79, 1989. 15. Spadoni G.L., Cianfarani S., Bernardini S., Vaccaro F., Galasso C., Boscherini B. Growth hormone treatment in children with sporadic primary microcephaly. American Journal of Diseases in Childhood 143, 1282-1283, 1989. 16. Boscherini B., Cianfarani S., Spadoni G.L. Clinical features of growth hormone (GH) deficiency. Journal of Endocrinological Investigation 12, 17-19, 1989. 17. Holly JMP, Edeb JA, Alaghband-Zadeh J, Carter GD, Jemmott RC, Cianfarani S., Chard T, Wass JAH. Insulin-like growth factor binding proteins in follicular fluid from normal dominant and cohort follicles, polycystic and multicystic ovaries. Clinical Endocrinology 33, 53-64, 1990. 18. Vaccaro F, Cianfarani S., Spadoni GL, Spagnoli A, Bernardini S, Galasso C, Boscherini B. Growth hormone therapy in non GH-deficient short children. Rivista Italiana di Pediatria 16, 528-534, 1990. 19. Spadoni GL, Spagnoli A, Cianfarani S., Del Principe D, Menichelli A, Di Giulio S, Boscherini B. Enhancement of phorbol diester-stimulated respiratory burst in human polymorphonuclear leukocytes by growth hormone. Acta Endocrinologica (ora European Journal of Endocrinology) 124, 589-594, 1991. 20. Spadoni G.L., Rossi P., Ragno W., Galli E., Cianfarani S., Galasso C., Boscherini B. Immune function in growth hormone deficient children treated with biosynthetic growth hormone. Acta Paediatrica Scandinavica 80, 75-79, 1991. 21. Cianfarani S., Vaccaro F, Spadoni GL, Galasso C, Bernardini S, Spagnoli A, Boscherini B. Abnormal growth velocity does not impair the attainment of target height in "small-delay" children. Acta Medica Auxologica 23, 245-251, 1991. 22. Bernardini S, Spadoni GL, Cianfarani S, Scalera G, Cives C, Vaccaro F, Pasquino AM, Boscherini B. Growth hormone response to growth hormone releasing factor in Turner's syndrome. Acta Medica Auxologica 23, 173-178, 1991. 23. Bernardini S, Spadoni GL, Cianfarani S, Vaccaro F, Pasquino AM, Boscherini B. Growth hormone secretion in Noonan's syndrome. Journal of Pediatric Endocrinology (now Journal of Pediatric Endocrinology and Metabolism) 4, 217-221, 1991. 24. Cianfarani S. New modulators of growth: the somatomedin- binding proteins. Rivista Italiana di Pediatria 18, 119-124, 1992. 25. Cianfarani S., Holly J.M.P., Pasquino A.M., Vaccaro F., Spadoni G.L., Bernardini S., Segni M., Boscherini B. Insulin-like growth factor binding protein-1 (IGFBP-1) levels in Turner syndrome. Hormone and Metabolic Research 24, 537-540, 1992. 26. Pasquino A.M., Bernardini S., Cianfarani S., Mancuso G., Marchione S.A., Passeri F., Pucarelli I., Spadoni G.L. Growth hormone assessment and three years' hGH therapy in girls with Turner syndrome. Hormone Research 38, 120-124, 1992. 27. Tedeschi B, Spadoni G.L., Sanna M.L., Vernole P., Caporossi D., Cianfarani S., Nicoletti B, Boscherini B. Increased chromosome fragility in lymphocytes of short normal children treated with recombinant human growth hormone. Human Genetics 91, 459-463, 1993 28. Cianfarani S., Nicholl R.M., Medbach S., Charlesworth M.C., Savage M.O. Idiopathic hypothalamus-pituitary dysfunction: review of five cases. Hormone Research 39, 47-50, 1993. 29. Cianfarani S., Frost V.J., Savage M.O., Holly J.M.P. Glucose does not influence the insulin-like growth factor (IGF) binding to carrier proteins (IGFBPs): analysis of rat and human serum by western ligand blotting. Experientia (now Cellular and Molecular Life Sciences) 49, 699-701, 1993. 30. Cianfarani S., Vaccaro F., Pasquino A.M., Marchione S.A., Passeri F., Spadoni G.L., Bernardini S., Spagnoli A., Boscherini B. Reduced growth hormone (GH) secretion in Turner syndrome: is body weight a key factor? Hormone Research, 41, 27-32, 1994. 31. Bernardini S, Cianfarani S, Spagnoli A, Melino G, Annicchiarico-Petruzzelli M, Massoud R, Boscherini B, Finazzi-Agrò A, Rosenfeld RG, Federici G. Expression and down regulation by retinoic acid of IGF binding protein-2 and 4 in medium from human neuroblastoma cells. Journal of Neuroendocrinology 6, 409-413, 1994. 32. Cianfarani S, Vaccaro F, Boscherini B. What is the rationale of growth hormone therapy in Turner syndrome? Lancet 344, 114-115, 1994. 33. Cianfarani S., Boscherini B. La sindrome di Noonan. Prospettive in Pediatria 25, 25-32, 1995. 34. Bernardini S, Cianfarani S, Pianca C, Massoud R, Germani D, Melino G, Federici G. Insulin-like growth factor binding protein-1 serum levels in neuroblastoma. Clinical Chemistry and Enzimology Communications 6, 359-363, 1995. 35. Vaccaro F, Cianfarani S, Pasquino AM, Boscherini B. Is the obesity- related insulin status the cause of the blunted growth hormone secretion in Turner syndrome? Metabolism 44, 1033-1037, 1995. 36. Spagnoli A., Spadoni G.L., Cianfarani S., Pasquino A.M., Troiani S., Boscherini B. Predicting outcome of growth hormone therapy in children with idiopathic short stature. Journal of Pediatrics 126, 905-909, 1995. 37. Cianfarani S., Boemi S., Spagnoli A., Cappa M., Argirò G., Vaccaro F., Manca Bitti M.L., Boscherini B. Is IGFBP-3 binding protein-3 assessment helpful for the diagnosis of GH deficiency? Clinical Endocrinology 43, 43-47,1995. 38. Municchi G., Pasquino A.M., Pucarelli I., Cianfarani S., Passeri F. Growth hormone treatment in Noonan syndrome: report of four cases who reached final height. Hormone Research 44, 164-167,1995. 39. Cianfarani S., Vitale S., Stanhope R., Boscherini B. Imperforate anus, bilateral hydronephrosis, bilateral undescended testes, and pituitary hypoplasia: a variant of Hall-Pallister syndrome or a new syndrome? Acta Paediatrica 84, 1322-1324, 1995. 40. Spagnoli A., Branca F., Spadoni G.L., Cianfarani S., Pasquino A.M., Argirò G., Vitale S., Robins S.P., Boscherini B. Urinary pyridinium collagen cross-links predict growth performance in children with idiopathic short stature and with growth hormone (GH) deficiency. Skeletal metabolism during GH treatment. Journal of Clinical Endocrinology and Metabolism 81,3589-3593,1996. 41. Cianfarani S., Germani D., Rossi P., Spagnoli A., Mercanti D. Do insulin-like growth factor binding proteins (IGFBPs) modulate the IGF-I growth promoting and differentiating effects in human neuroblastoma cells? European Journal of Endocrinology 135, 716-723, 1996. 42. Cianfarani S., Rossi P. Neuroblastoma and Insulin-like growth factor (IGF) system. New insights and clinical perspectives. European Journal of Pediatrics 156, 256-261, 1997. 43. Cianfarani S., Boscherini B. Il bambino con ritardo di crescita ad inizio intrauterino (IUGR, intrauterine growth retardation). Fisiopatologia dell’asse GH-IGF-I e tentativi terapeutici. Prospettive in Pediatria 108, 299-306, 1997. 44. Cianfarani S, Tedeschi B, Germani D, Prete SP, Rossi P, Vernole P, Caporossi D, Boscherini B. “In vitro” effects of growth hormone (GH) and insulin-like growth factor-I and -II (IGF-I and -II) on chromosome fragility and p53 protein expression in human lymphocytes. European Journal of Clinical Investigation 28, 41-47, 1998. 45. Cianfarani S, Germani D, Rossi L, Argirò G, Boemi S, Lemon M, Holly JMP, Branca F. IGF-I and IGF-binding protein-1 are related to cortisol in human cord blood. European Journal of Endocrinology 138, 524-529, 1998. 46. Balducci R, Toscano V, Tedeschi B, Mangiantini A, Toscano R, Galasso C, Cianfarani S, Boscherini B. A new case of Ambras syndrome associated with a paracentric inversion (8) (q12:q22). Clinical Genetics 53, 466-468, 1998. 47. Cianfarani S, Germani D, Rossi P, Rossi L, Germani A, Ossicini C, Zuppa A, Argirò G, Holly JMP, Branca F. Intrauterine growth retardation (IUGR): Evidence for the activation of the IGF-related growth promoting machinery and the presence of a cation- independent IGFBP-3 proteolytic activity by two months of life. Pediatric Research 44, 374-380, 1998. 48. Cianfarani S, Germani D, Branca F. Low birth weight and adult insulin resistance: the catch-up growth hypothesis. Archives of Disease in Childhood, 81, F71-F73, 1999. 49. Cianfarani S Low birth weight and IGF system, Physiology and clinical implications. Rivista di Clinica Dietologica 27, 89-92, 1999. 50. Puglianiello A, Germani D, Rossi P and Cianfarani S Insulin-like growth factor-I (IGF-I) stimulates chemotaxis of human neuroblasts. Involvement of type I IGF receptor, insulin-like growth factor binding proteins (IGFBPs), phosphatidylinositol (PI)-3 kinase pathway and plasmin system. Journal of Endocrinology 165, 123-131, 2000. 51. Rossi L., Branca F. and Cianfarani S. Collagen cross-links and early postnatal growth in newborns with intrauterine growth retardation. Metabolism 49, 1467-1472, 2000. 52. Elias LLK, Huebner A, Metherell LA, Canas A, Warne GL, Manca Bitti ML, Cianfarani S, Clayton PE, Savage MO, Clark AJL. Tall stature in familial glucocorticoid deficiency. Clinical Endocrinology 53, 423-430, 2000. 53. Cianfarani S, Bonfanti R, Manca Bitti ML, Germani D, Boemi S, Chiumello G, Boscherini B. Growth and Insulin-like Growth Factors (IGFs) in Children with Insulin- Dependent Diabetes Mellitus (IDDM) at Onset of Disease. Evidence for Normal Growth, Age Dependency of the IGF System Alterations and Presence of a Small (18 kDa) IGFBP-3 Fragment in Serum. Journal of Clinical Endocrinology and Metabolism 85, 4162-4167, 2000. 54. Cianfarani S, Geremia C, Germani D, Scirè G, Maiorana A, Boemi S. Insulin resistance and insulin-like growth factors (IGFs) in children with intrauterine growth retardation (IUGR). Is catch-up growth a risk factor? Hormone Research 55 (Suppl.1) 7-10, 2001. 55. Rossi L, Migliaccio S, Corsi A, Marzia M, Bianco P, Teti A, Gambelli L, Cianfarani S, Paoletti F, Branca F. Reduced growth and skeletal changes in zinc deficient growing rats are the consequences of impaired growth plate activity and of zinc depletion-induced inanition. Journal of Nutrition 131, 1142-1146, 2001. 56 Tadin M, Braverman E, Cianfarani S, Sobrino AJ,m Levy B, Christiano AM, Warburton D. Complex cytogenetic rearrrangement of chromosome 8q in a case of Ambras syndrome. American Journal of Medical Genetics 102, 100-104, 2001. 57. Branca F, Spagnoli A, Cianfarani S, Spadoni GL, Golden MHN, Boscherini B, Valtuena S, Robins SP. Urinary excretion of pyridinium cross-links in short children treated with growth hormone. Journal of Pediatric Endocrinology and Metabolism 15, 27-34, 2002. 58 Cianfarani S, Geremia C, Scott CD, Germani D. Growth, Insulin-like growth factor (IGF) system and cortisol in children with intrauterine growth retardation (IUGR). Is catch-up growth affected by reprogramming of the hypothalamic-pituitary-adrenal axis (HPAA)? Pediatric Research 51, 94-99, 2002. 59 Cianfarani S, Tondinelli T, Spadoni GL, Scirè G, Boemi S, Boscherini B. Height Velocity and IGF-I Assessment in the Diagnosis of Childhood Onset GH Insufficiency. Do we still need a Second GH Stimulation Test? Clinical Endocrinology 57, 161-167, 2002. 60 Cianfarani S. Foetal origin of adult diseases: just a matter of stem cell number? Medical Hypotheses 61:401-404, 2003. 61 Cianfarani S, Maiorana A, Geremia C, Scirè G, Spadoni GL, Germani D. Blood Glucose Concentrations are Reduced in Children Born Small for Gestational Age (SGA) and TSH Levels are Increased in SGA with Blunted Postnatal Catch- up Growth. Journal of Clinical Endocrinology and Metabolism 88, 2699-2705, 2003. 62 Cianfarani S., Martinez C, Maiorana A, Scirè G, Spadoni G.L., Boemi S. Adiponectin Levels Are Reduced in Children Born Small for Gestational Age (SGA) and are Inversely Related to Postnatal Catch-up Growth. Journal of Clinical Endocrinology and Metabolism 89: 1346-1351, 2004. 63 Scommegna S., Galeazzi D., Picone S., Farinelli E., Agostino R., Bozzao A., Boscherini B, Cianfarani S. Neonatal Identification of Pituitary Aplasia:a Life- Saving Diagnosis. Review of Five Cases. Hormone Research 62, 10-16, 2004. 64 Geremia C, Cianfarani S. Insulin sensitivity in children born small for gestational age (SGA) Review of Diabetic Sciences 1, 58-65, 2004. 65 Cianfarani S. La pubertà precoce. Medico e Bambino 23, 485-491, 2004. 66 Torre P, Bertoli M, Di Giovanni S, Scommegna S., Conte C, Novelli G, Cianfarani S. Endocrine and Neuropsychological Assessment in a Child with a Novel Mutation of Thyroid Hormone Receptor. Response to 12-months Triiodothyroacetic Acid (TRIAC) Therapy. Journal of Endocrinological Investigation 28, 657-662, 2005. 67 Cianfarani S, Liguori A, Germani D. IGF-I and IGFBP-3 assessment in the management of childhood onset growth hormone deficiency. Endocrine Development 9, 66-75, 2005 68 Cianfarani S. Il ruolo dei fattori di crescita GH-dipendenti nella diagnosi del deficit di GH. Area Pediatrica 4, 44-48, 2005. 69 Cianfarani S., Puglianiello A, Germani D. Central reprogramming in intrauterine growth retardation. Minerva Pediatrica 57(Suppl.1 N3):71-73, 2005. 70 Cianfarani S., Liguori A., Boemi S., Maghnie M, Iughetti L., Wasniewska M., Street M.E., Zucchini S., Aimaretti G., Grmani D. Inaccuracy of IGFBP-3 Assessment in the Diagnosis of Growth Hormone Deficiency (GHD) from Childhood to Young Adulthood: Association to Low GH-Dependency of IGF-II and Presence of Circulating IGFBP-3 18 kD Fragment. Journal of Clinical Endocrinological and Metabolism, 90, 6028-6034, 2005. 71 Cianfarani S, Ladaki C, Geremia C. Hormonal regulation of post-natal growth in SGA children Hormone Research 65 (Suppl. 3): 70-74, 2006. 72 Cianfarani S, Liguori A. Sensibility and Specificity of Growth Factors in GH Deficiency. Journal of Endocrinological Investigation, 29 (Suppl.), 71-75, 2006. 73. Geremia C, Cianfarani S. Laboratory Tests and Measurements in Children Born Small for Gestational Age (SGA) Clinica Chimica Acta 364, 113-123, 2006. 74 Puglianiello A and Cianfarani S Central control of glucose metabolism The Review of Diabetic Studies 3, 54-60, 2006. 75 Kelberman D, Rizzoti K, Bitner-Glindzicz M, Cianfarani S, Collins J, Chong WK, Kirk JMW, Achermann JC, Ross R, Carmignac D, Lovell-Badge R, Robinson ICAF, Dattani MT Mutations within Sox2/SOX2 are Associated with Hypopituitarism in Mouse and Humans. Journal of Clinical Investigation 116, 2442-2455, 2006. 76 Scirè G, D’Anella G, Cristofori L, Mazzuca V, and Cianfarani S Marked left ventricular hypertrophy mimicking hypertrophic cardiomyopathy associated with steroid therapy for congenital adrenal hyperplasia. Journal of Cardiovascular Medicine 8(6):465-7, 2007 77. Federico G., Street M.E., Maghnie M., Caruso-Nicoletti M., Loche S., Bertelloni S., and Cianfarani S. Assessment of circulating levels of insulin-like growth factors in the diagnosis diagnosis of isolated childhood-onset isolated growth hormone deficiency. A proposal of the Italian Society for Pediatric Endocrinology and Diabetes. Journal of Endocrinological Investigation 29:732-737, 2006. 78. Ghirri P, Ladaki C, Bartoli A, Scirè G, Vuerich M, Spadoni GL, Maiorana M, Geremia C, Boldrini A , and Cianfarani S. Low Birth Weight for Gestational Age Associates with Reduced Glucose Concentrations at Birth, Infancy and Childhood. Hormone Research 67:123–131, 2007. 79. Clayton PE, Cianfarani S, Czernichow P, Johannsson G, Rapaport R, Rogol A Management of the Child Born Small for Gestational Age Child (SGA) through to Adulthood: A Consensus Statement of the International Societies of Paediatric Endocrinology and the Growth Hormone Research Society. Journal of Clinical Endocrinology and Metabolism 92, 804-810, 2007. 80. Antonella Puglianiello, Daniela Germani, Sara Antignani, Gianpaolo Scalia Tomba and Stefano Cianfarani. Changes in the Expression of Hypothalamic Lipid Sensing Genes in Rat Model of Intrauterine Growth Retardation (IUGR). Pediatric Research 61:433-437, 2007. 81. Zucchini S, Wasniewska M, Cisternino M, Salerno M, Iughetti L, Maghnie M, Street ME, Caruso-Nicoletti M, Cianfarani S. Adult height in children with short stature and idiopathic delayed puberty after different management. European Journal of Pediatrics 167, 677-681, 2008 82. Cianfarani S. Endocrine-metabolic follow-up of the small for gestational age (SGA) infant. Minerva Pediatr 59, 545-546, 2007 83. Cianfarani S, Geremia C, Puglianiello A, Mairana A, Germani D. Late Effects of Disturbed IGF Signaling in Congenital Diseases. Endocrine Development 11, 16-27, 2007. 84. Maiorana A, Del Bianco C, and Cianfarani S. Adipose Tissue: a Metabolic Regulator. Potential Implications for the Metabolic Outcome of Subjects Born Small for Gestational Age (SGA). The Review of Diabetic Studies, 4, 131-143, 2007. 85. Scirè G, Del Bianco C, Spadoni GL, and Cianfarani S Growth hormone (GH) therapy does not alter the IGF-I/IGFBP-3 molar ratio in GH deficient children. Journal of Endocrinological Investigation 31(2):153-8, 2008. 86. Torre P, Ladaki C, Scirè G, Spadoni GL, and Cianfarani S. Catch-up growth in body mass index (BMI) is associated neither with reduced insulin sensitivity nor with altered lipid profile in children born small for gestational age (SGA). Journal of Endocrinological Investigation 31(9):760-4, 2008. 87. Germani D, Puglianiello A and Cianfarani S. Uteroplacental Insufficiency Down Regulates Insulin Receptor and Affects Expression of Key Enzymes of Long-chain Fatty Acid (LCFA) Metabolism in Skeletal Muscle at Birth. Cardiovascular Diabetology, 7:14, 2008. 88. Elizabeth Brink, Veronique Coxam, Simon Robins, Kristiina Wahala, Aedin Cassidy, and Francesco Branca on behalf of the PHYTOS Investigators Long-term consumption of isoflavone-enriched foods does not affect bone mineral density, bone metabolism, or hormonal status in early postmenopausal women: a randomized, double-blind, placebo controlled study1. Americal Journal of Clinical Nutrition 87:761–70, 2008. 89. Katherine A. Fantauzzo, Marija Tadin-Strapps, Yun You, Sarah E. Mentzer, Friedrich A.M. Baumeister, Stefano Cianfarani, Lionel Van Maldergem, Dorothy Warburton, John P. Sundberg and Angela M. Christiano. A position effect on TRPS1 is associated with Ambras syndrome in humans and the Koala phenotype in mice. Human Molecular Genetics 17(22):3539-51, 2008 90. P Cohen, AD Rogol, CL Deal, P Saenger, EO Reiter, JL Ross, SD Chernausek, MO Savage, JM Wit on behalf of the 2007 ISS Consensus Workshop participants*Consensus Statement on the Diagnosis and Treatment of Children with Idiopathic Short Stature: A Summary of the Growth Hormone Research Society, the Lawson Wilkins Pediatric Endocrine Society and the European Society for Paediatric Endocrinology Workshop. Journal of Clinical Endocrinology and Metabolism 93(11):4210-4217. 2008. 91. Liguori A, Cianfarani S Postnatal onset of severe growth retardation after in utero exposure to carbamazepine and phenobarbital: a case report Journal of Medical Case Reports 2009; 3:7300 doi: 10.1186/1752-1947-3-7300 92 Pedicelli S, Peschiaroli E, Violi E, and Cianfarani S. Controversies in the definition and treatment of idiopathic short stature (ISS). Journal of Clinical Research in Pediatric Endocrinology. 2009; 1(3):105-115 93. Puglianiello A, Germani D, and Cianfarani S. Exposure to uteroplacental insufficiency reduces the expression of signal transducer and activator of transcription 3 (STAT3) and proopiomelanocortin (POMC) in the hypothalamus of newborn rats. Pediatric Research 66:208-211, 2009 94. Maiorana A, Fierabracci A and Cianfarani S Isolation and characterization of omental adipose progenitor cells in children: a potential tool to unravel the pathogenesis of metabolic syndrome. Hormone Research 2009;72:348–358 95. Maiorana A, Cianfarani S Impact of Growth Hormone Therapy on Adult Height of Children Born Small for Gestational Age: A Systematic Review of Randomized Controlled Trials. Pediatrics, 124, E519-E531, 2009. 96. Giacomozzi C, Savage MO and Cianfarani S Deficit primario di IGF-I. Implicazioni diagnostico-terapeutiche. Il Pediatra, giugno, 26-39. 2010 97. Bertelloni S, Garofalo P, and Cianfarani S. Il ritardo dello sviluppo puberale maschile: trattamento con androgeni. Rivista Italiana di Medicina dell’Adolescenza 8, 5-10,2010 98. Spadoni and Cianfarani S Bone age assessment in the work up of children with endocrine disorders Hormone Research in Paediatrics Vol. 73, No. 1, pp 2 - 5 , 2010 99. Giacomozzi C, Gullotta F, Federico G, Colapietro I, Nardone, AM, and Cianfarani S, Premature Ovarian Failure associated to the Absence of Pubic and Axillary Hair in a de novo Translocation X;15 (q24;q26.3). American Journal of Medical Genetics 2010 May;152A(5):1305-9. 100. Giacomozzi C, Ghirri P, Lapolla R, Bartoli A, Scirè G, Serino L, Germani D, Boldrini A, and Cianfarani S. Retinol-binding protein 4 in neonates born small for gestational age. Journal of Endocrinological Investigation 2010 Apr;33(4):218-21. 101. Nobili V, Cianfarani S, Agostoni C. Programming, metabolic syndrome, and NAFLD: the challenge of transforming a vicious into a virtuous cycle. Journal of Hepatology 2010 Jun;52(6):788-90. 102. Federico G, Cianfarani S Usefulness of serum insulin-like growth factor-I (IGF-I) assessment in the diagnosis of childhood-onset GH deficiency. Hormone Research in Paediatrics 74, 145-148, 2010 103. Bertelloni S, Garofalo P, and Cianfarani S. The role of androgen therapy in hypogonadal adolescent males Homone Research in Paediatrics 74, 292-296, 2010 104. Cianfarani S Grand Challenges in Pediatric Endocrinology Frontiers in Pediatric Endocrinology doi:10.3389/fendo.2010.00001 105. Deodati A, Peschiaroli E, Cianfarani S. Conseguenze endocrine e metaboliche del bambino nato SGA. Rivista Italiana di Medicina dell’Adolescenza 3, Suppl. 8 1-6, ,2010 106. Liguori A, Puglianiello A, Germani D, Deodati A, Peschiaroli E and Cianfarani S, Epigenetic changes predisposing to type 2 diabetes in intrauterine growth retardation. Frontiers in Pediatric Endocrinology doi: 10.3389/fendo.2010.00005 107. Deodati A and Cianfarani S. Impact of Growth Hormone Therapy on Adult Height of Children with Idiopathic Short Stature: A Systematic Review of Randomized and non-Randomized Controlled Trials. British Medical Journal, 2011;342:c7157 108. Zanni G, Barresi S, Travaglini L, Bernardini L, Digilio MC, Mercuri E, Cianfarani S, Ferraris A, Masotti A, Novelli A, Valente EM, Dallapiccola B, Bertini ES FGF17, a gene involved in cerebellar development is downregulated in a patient with Dandy-Walker Malformation carrying a de novo 8p deletion. Neurogenetics 2011;12(3):241-5 109. Pedicelli S, Scirè G, Bertelloni S, Peschiaroli E, Deodati A, Garofalo P, Cianfarani S. Il deficit di GH nel periodo di transizione (GH deficiency in the transition phase). Il Pediatra 2011, giugno, 48-54 110. Fernando Cassorla, Stefano Cianfarani, Fritz Haverkamp, Jose Labarta, Sandro Loche, Xiaoping Luo, Mohammad Maghnie, Veronica Mericq, Agota Muzsnai, Svante Norgren, Marja Ojaniemi, Zuzana Pribilincova, Sofia Quinteiro, Lars Sävendahl, Angela Spinola e Castro, Christoph Gasteyger. Growth Hormone and Treatment Outcomes: Expert Review of Current Clinical Practice Pediatric Endocrinology Reviews, 2011 Dec;9(2):554-65. 111. Fernando Cassorla, Stefano Cianfarani, Fritz Haverkamp, Jose Labarta, Sandro Loche, Xiaoping Luo, Mohammad Maghnie, Veronica Mericq, Agota Muzsnai, Svante Norgren, Marja Ojaniemi, Zuzana Pribilincova, Sofia Quinteiro, Lars Sävendahl, Angela Spinola e Castro, Christoph Gasteyger. Growth Hormone and Treatment Outcomes: Expert Review of Current Clinical Practice Pediatric Endocrinology Reviews, Dec;9(2):554-65, 2011 112. Deodati A, Peschiaroli E, and Cianfarani S. Review of Growth Hormone Randomized Controlled Trials in Children with Idiopathic Short Stature. Hormone Research in Paediatrics 76 (Suppl. 3):40B-42 (DOI: 10.1159/000330157), 2011 113. Canani RB, Di Costanzo M, Leone L, Bedogni G, Brambilla P, Cianfarani S, Nobili V, Pietrobelli A, Agostoni C. Epigenetic mechanisms elicited by nutrition in early life. Nutr Res Rev. Dec;24(2):198-205, 2011 114. Cianfarani S. Chairman's summary: Diagnostic techniques for identifying children with idiopathic short stature. Horm Res Paediatr. 76 Suppl 3:16.Epub 2011 Sep 7, 2011. 115. Cohen A, Lala R, Ravaglia A, Bernasconi S, Boscherini B, Cianfarani S, Pocecco M, Maghnie M, Panei P Modifiche della prescrizione dell’ormone della crescita. Una proposta dell’ACP. QUADERNI ACP, vol. 18, p. 42-44, 2011 116. Alisi A, Cianfarani S, Manco M, Agostoni C, Nobili V. Nonalcoholic fatty liver disease and metabolic syndrome in adolescents: pathogenetic role of genetic background and intrauterine environment. Annals of Medicine, Feb;44(1):29-40 2012 117. S. Cianfarani, C. Agostoni, G. Bedogni, R. Berni Canani, P. Brambilla, V. Nobili, A. Pietrobelli Effect of Intrauterine Growth Retardation on Liver and Long-Term Metabolic Risk. International Journal of Obesity. Oct;36(10):1270-7, 2012. 118. G. Bedogni, G. Giannone, M. Maghnie, C. Giacomozzi, N. Di Iorgi, S. Pedicelli, E. Peschiaroli, G. Melioli, M. Muraca, M. Cappa, and S. Cianfarani. Serum insulin-like growth factor-I (igf-I) reference ranges for chemiluminescence assay in childhood and adolescence. Data from a population of in- and out-patients. Growth Hormone and IGF Research, 22:134-138, 2012. 119. Nobili V, Bedogni G, Berni Canani R, Brambilla P, Cianfarani S, Pietrobelli A, Agostoni C The Hepato-Metabolic Syndrome In Children: A Distinct Phenotype With High Metabolic Risk? Pediatric Obesity Dec;7(6):e75-80, 2012. 120. Cianfarani S Long-term safety of growth hormone therapy: still a controversial issue. Frontiers in endocrinology, vol. 3, p. 1-2, 2012. doi: 10.3389/fendo.2012.00115 121. Cianfarani S Insulin-like growth factor-II (IGF-II): new roles for an old actor. Frontiers in endocrinology, vol.3, 1-4, 2012, doi: 10.3389/fendo. 2012.00118 122. Benevento D, Bizzarri C, Patera IP, Ravà L, Schiaffini R, Ciampalini P, Cianfarani S, Cappa M. Birth weight influences the clinical phenotype and the metabolic control of patients with type 1 diabetes (T1D) . Diabetes/metabolism research and reviews Jan;29(1):60-5, 2013 123. Inzaghi E and Cianfarani S The challenge of growth hormone deficiency (GHD) diagnosis and treatment during the transition from puberty into adulthood. Frontiers in Endocrinology 4:34. doi: 10.3389/fendo.2013.00034, 2013 124. Wit. JM. Ranke MB, Albertsson-Wikland K, Carrascosa A, Rosenfeld RG, Van Buuren S, Kristom B, Schoenau E, Audi L, Hokken.Koelega A, Bamg P, Junh H, Blum WF, Silverman LA, COhen P, Cianfarani S, Deal C, Clayton PE, de Graaf L, Dahlgren J, Kleintjens J, Roelants M. Personalized approach to growth hormone treatment: clinical use of growth prediction models. Horm Res Paediatr. 79(5):257-70, 2013 125. Deodati A, Inzaghi E, Liguori A, Puglianiello A, germani D, Brufani C, Fintini D, Cappa M, Barbetti F, Cianfarani S. IGF2 Methylation Is Associated with Lipid Profile in Obese Children. Horm Res Paediatr, Jun 14:361-367, 2013 126. Bizzarri C, Benevento D, Patera IP, Bongiovanni M, Boiani A, Cianfarani S, Cappa M Residual beta-cell mass influences growth of pre-pubertal children with type 1 diabetes. Horm Res Paediatr 80(4):287-92, 2013 127. Bizzarri C, Spadoni GL, Bottaro G, Monatanari G, Giannone G, Cappa M, Cianfarani S. The response to gonadotropin releasing hormone (GnRH) stimulation test does not predict the progression to true precocious puberty in girls with onset of premature thelarche in the first three years of life. Journal of Clinical Endocrinology and Metabolism, 99(2):433-9, 2014. 128. Valerio Nobili, Valentina Giorgio, Daniela Liccardo, Giorgio Bedogni, Giuseppe Morino, Anna Alisi, and Stefano Cianfarani. Vitamin D levels and liver histological alterations in children with non-alcoholic fatty liver disease (NAFLD). European Journal of Endocrinology 170(4):547-53, 2014. 129. Boscherini B and Cianfarani S. Considerazioni sulla diagnosi di deficienza idiopatica isolata di ormone della crescita Quaderni ACP 21(1): 31-32, 2014. 130. Cafiero G, Fintini D, Brufani C, Fiori R, Giordano U, Turchetta A, Deodati A, Cappa M and Cianfarani S Cardiovascular fitness is impaired in children that are born small for their gestational age. Acta Paediatrica 103(5):e219-21, 2014 131. Stefano Cianfarani, Elena Inzaghi, Anna Alisi, Daniela Germani, Antonella Puglianiello, V alerio Nobili. Insulin-like Growth Factor–I and –II Levels are Associated with the Progression of Nonalcoholic Fatty Liver Disease in Obese Children. Journal of Pediatrics 165(1):92-8, 2014. 132. Annalisa Deodati, Barbara Baldini Ferroli and Stefano Cianfarani. Association between Growth Hormone Therapy and Mortality, Cancer and Cardiovascular Risk: Systematic Review and Meta-Analysis. Growth Hormone and IGF Research 24:105-111, 2014. 133. Elena Inzaghi, Stefano Cianfarani, Valerio Nobili. Insulin-Like Growth Factors (IGF-I And –II): New Actors in the Development of Non-Alcoholic Fatty Liver Disease. Expert Reviews of Endocrinology and Metabolism 9:193-195, 2014. 134. S. Cianfarani Is High Dose Growth Hormone Treatment During Puberty Worthwhile? Hormone Research in Paediatrics, 82(3):143-4, 2014 135. Cianfarani S Editorial Hormone Research in Paediatrics 81:1, 2014 136 Bizzarri C, Benevento D, Giannone G, Bongiovanni M, Anziano M, Patera IP, Cappa M and Cianfarani S. Sexual dimorphism in growth and insulin-like growth factor-I in children with type 1 diabetes mellitus. Growth Hormone and IGF Research, 24(6):256-9, 2014. 137 Carla Bizzarri, Stefania Pedicelli, Brunetto Boscherini, Giorgio Bedogni, Marco Cappa and Stefano Cianfarani Early retesting by GHRH + arginine test shows normal GH response in most children with idiopathic GH deficiency. Journal of Endocrinological Investigation, Apr;38(4):429-36, 2015 138. Stefania Pedicelli, Paola Alessio, Giuseppe Scirè, Marco Cappa, and Stefano Cianfarani. Routine Screening by Brain Magnetic Resonance Imaging Is not Indicated in Every Girl with Onset of Puberty Between the Ages of Six and Eight Years. Journal of Clinical Endocrinology and Metabolism, 99(12):4455-61, 2014. 139. V. Pampanini, A. Boiani, C. De Marchis, C. Giacomozzi, R. Navas, R. Agostino, F. Dini, P.Ghirri, and S. Cianfarani Preterm Infants with Severe Extrauterine Growth Retardation (EUGR) Are at High Risk of Growth Impairment during Childhood. European Journal of Pediatrics, 174(1):33-41, 2015. 140. C. Giacomozzi, A. Deodati, M.G. Shaikh, S.F. Ahmed, and S. Cianfarani. The Impact of Growth Hormone Therapy on Adult Height in Noonan Syndrome: a systematic review. Hormone Research in Paediatrics, 83(3):167-76, 2015. 141. D. Fintini, E. Inzaghi, M. Colajacomo, S. Bocchini, G. Grugni, C. Brufani, M. Cappa, V. Nobili, S. Cianfarani, A. Crinò Non-Alcoholic Fatty Liver Disease (NAFLD) in children and adolescents with Prader–Willi Syndrome (PWS). Pediatric Obesity 11(3):235-8, 2016 142 Swerdlow AJ, Cooke R, Albertsson-Wikland K, Borgström B, Butler G, Cianfarani S, Clayton P, Coste J, Deodati A, Ecosse E, Gausche R, Giacomozzi C, Kiess W, Hokken-Koelega AC, Kuehni CE, Landier F, Maes M, Mullis PE, Pfaffle R, Sävendahl L, Sommer G, Thomas M, Tollerfield S, Zandwijken GR, Carel JC. Description of the SAGhE Cohort: A Large European Study of Mortality and Cancer Incidence Risks after Childhood Treatment with Recombinant Growth Hormone. Hormone Research in Paediatrics, 84, 172-183, 2015. 143. Pampanini V, Pedicelli S, Gubinelli J, Scirè G, Cappa M, Boscherini B, and Cianfarani S. Brain Magnetic Resonance Imaging as First-Line Investigation for Growth Hormone Deficiency Diagnosis in Early Childhood. Hormone Research in Paediatrics, 84(5):323-30, 2015. 144. D B Allen, P Backeljauw, M Bidlingmaier, BMK Biller, M Boguszewski , P Burman, G Butler, K Chihara, J Christiansen, S Cianfarani, P Clayton, D Clemmons, P Cohen, F Darendeliler, C Deal, D Dunger, E M Erfurth, J S Fuqua, A Grimberg, M Haymond, C Higham, K Ho, A R Hoffman, A Hokken-Koelega, G Johannsson, A Juul, J Kopchick, P Lee, M Pollak, S Radovick, L Robison, R Rosenfeld, R J Ross, L Savendahl, P Saenger, H Toft Sorensen, K Stochholm, C Strasburger, A Swerdlow, M Thorner. Growth Hormone Safety Workshop Position Paper: a critical appraisal of recombinant human growth hormone therapy in children and adults. Eur J Endocrinol. 174(2):P1-9, 2016. 145. Schiaffini R, Liccardo D, Alisi A, Benevento D, Cappa M, Cianfarani S, Nobili V Early Glucose Derangement Detected by Continuous Glucose Monitoring and Progression of Liver Fibrosis in Nonalcoholic Fatty Liver Disease: An Independent Predictive Factor? Hormone Research in Paediatrics 85(1):29-34, 2016. 146. Brambilla P, Bedogni G, Pietrobelli A, Cianfarani S , Agostoni C. Predictors of blood pressure at 7-13 years: The “new Millennium Baby” study. Nutrition, Metabolism and Cardiovascular Diseases. 26(8):706-12, 2016 147. Deodati A, Sallemi A, Maranghi , Germani D, Puglianiello A, Baldari F, Busani L, Mancini FR, Tassinari R, Mantovani A, Cianfarani S Serum Levels of Polybrominated Diphenyl Ethers in Girls with Premature Thelarche. Hormone research in Paediatrics 86(4):233-239, 2016. 148. Savage MO, Backeljauw PF, Calzada R, Cianfarani S, Dunkel L, Koledova E, Wit JM, Yoo HW. Early Detection, Referral, Investigation, and Diagnosis of Children with Growth Disorders. Hormone Research in Paediatrics 85(5):325-32, 2016 149. Fischer-Posovszky P, Roos J, Kotnik P, Battelino T, Inzaghi E, Nobili V, Cianfarani S, Wabitsch M. Functional Significance and Predictive Value of MicroRNAs in Pediatric Obesity: Tiny Molecules with Huge Impact. Hormone research in Paediatrics 86(1):3-10, 2016. 150. M. Cappa, L. Iughetti, S. Loche, M. Maghnie, A. Vottero. GeNeSIS National Board on behalf of the GeNeSIS Italian Investigators. Efficacy and safety of growth hormone treatment in children with short stature: the Italian cohort of the GeNeSIS clinical study. Journal of Endcorinological Investigation 39:667–677, 2016 151. Cambiaso P, Bottaro G, Cianfarani S, Tomà P, de Vito R, Cappa M. An Incidental Finding of Bilateral Adrenal Lymphoma The American Journal of Medical Sciences 52(1):80. doi: 10.1016/j.amjms.2016.02.018., 2016. 152. Bizzari C, Pedicelli S, Cappa M, Cianfarani S. Water Balance and 'Salt Wasting' in the First Year of Life: The Role of Aldosterone-Signaling Defects. Hormone Research in Paediatrics 86(3):143-153., 2016. 153. Deodati A, Cianfarani S. Trattamento con ormone della crescita in bambini nati piccoli per l’età gestazionale L’Endocrinologo 17(4):183-187, 2016 154. Cianfarani S, Soder O. Endocrine disruptors and child health. New insights. Hormone Research in Paediatrics Sep 16;86(4), 2016 155. Della Corte C, Carpino G, De Vito R, De Stefanis C, Alisi A, Cianfarani S, Overi D, Mosca A, Stronati L, Cucchiara S, Raponi M, Gaudio E, Byrne CD, Nobili V. Docosahexanoic Acid Plus Vitamin D Treatment Improves Features of NAFLD in Children with Serum Vitamin D Deficiency: Results from a Single Centre Trial. PLoS One. 2016 Dec 15;11(12):e0168216. doi: 10.1371/journal.pone.0168216. 156. Pampanini V, Germani D, Puglianiello A, Stukenborg JB, Reda A, Savchuk I, Kjartansdóttir KR, Cianfarani S, Soder O. Impact of uteroplacental insufficiency on postnatal rat male gonad. Journal of Endocrinology Feb;232(2):247-257, 2017. 157. Swerdlow AJ, Cooke R, Beckers D, Borgström B, Butler G, Carel JC, Cianfarani S, Clayton P, Coste J, Deodati A, Ecosse E, Gausche R, Giacomozzi C, Hokken-Koelega AC, Khan AJ, Kiess W, Kuehni CE, Mullis PE, Pfaffle R, Sävendahl L, Sommer G, Thomas M, Tidblad A, Tollerfield S, Van Eycken L, Zandwijken GR. Cancer risks in patients treated with growth hormone in childhood: the SAGHE European cohort study. Journal of Clinical Endocrinology and Metabolism 102:1661–1672, 2017. 158. Elena Inzaghi, Barbara Baldini Ferroli, Danilo Fintini, Armando Grossi, Valerio Nobili, Stefano Cianfarani Insulin-Like Growth Factors and Metabolic Syndrome in Obese Children. Hormone research in Paediatrics 87:400–404, 2017. 159. Francesca Santilli, Paola G. Simeone, Maria T. Guagnano, Marika Leo, Marica T. Maccarone, Augusto Di Castelnuovo, Cristina Sborgia, Riccardo C. Bonadonna, Ermanno Angelucci, Virginia Federico, Stefano Cianfarani, Lamberto Manzoli, Giovanni Davì, Armando Tartaro and Agostino Consoli. Effects of Liraglutide on Weight Loss, Fat Distribution, and β-Cell Function in Obese Subjects with Prediabetes or Early Type 2 Diabetes. Diabetes Care 2017 Nov;40(11):1556-1564 160 Deodati A, Cianfarani S. The rationale for growth hormone therapy in children with short stature. Journal of Clinical Research in Pediatric Endocrinology Dec 30;9(Suppl 2):23-32, 2017. 161 S. Brandt, J. Roos, E. Inzaghi, P. Kotnik, J. Kovac, T. Battelino, S. Cianfarani, V. Nobili, M. Colajacomo, W. Kratzer, C. Denzer, P. Fischer-Posovszky and M. Wabitsch Circulating levels of miR-122 and nonalcoholic fatty liver disease in pre-pubertal obese children. Pediatric Obesity 13(3):175-182, 2018. 162 Pampanini V, Inzaghi E, Germani D, Alterio A, Puglianiello A, Alisi A, Nobili V and Cianfarani S Serum Fetuin-A Levels in Obese Children with Biopsy Proven Nonalcoholic Fatty Liver Disease. Nutrition, Metabolism & Cardiovascular Diseases Jan;28(1):71-76, 2018. 163 Bizzarri C, Timpanaro TA, Matteoli MC, Patera IP, Cappa M, Cianfarani S. Growth trajectory in children with type 1 diabetes mellitus: the impact of insulin treatment and metabolic control. Hormone Research in Paediatrics. 89(3):172-177, 2018 164 Cinzia La Rocca, Francesca Maranghi, Sabrina Tait, Roberta Tassinari, Francesca Baldi, Giorgia Bottaro, Emma Buzzigoli, Fabrizia Carli, Stefano Cianfarani, Raffaele Conte, Annalisa Deodati, Amalia Gastaldelli, Anna Paola Pala, Andrea Raffaelli, Chiara Saponaro, Giuseppe Scirè, Gian Luigi Spadon, Luca Busani, the LIFE PERSUADED Project Group. The LIFE PERSUADED project approach on phthalates and bisphenol A biomonitoring in Italian mother-child pairs linking exposure and juvenile diseases. Environmental Science and Pollution Research, Jul 4. doi: 10.1007/s11356-018-2660-4, 2018. 165 Annalisa Deodati, Josepmaría Argemí, Daniela Germani, Antonella Puglianiello, Anna Alisi, Cristiano De Stefanis, Roberto Ferrero, Valerio Nobili, Tomás Aragón, Stefano Cianfarani The exposure to uteroplacental insufficiency is associated with activation of unfolded protein response in postnatal life. PLOS ONE Jun 13;13(6):e0198490. doi: 10.1371/journal.pone.0198490., 2018 166 Anna Alisi, Valentina Pampanini, Cristiano De Stefanis, Nadia Panera, Annalisa Deodati, Valerio Nobili, Stefano Cianfarani Expression of insulin-like growth factor I and its receptor in the liver of children with biopsy-proven NAFLD. PLOS ONE Jul 31;13(7):e0201566. 2018 167 Marzano F, Faienza MF, Caratozzolo MF, Brunetti G, Chiara M, Horner DS, Annese A, D’erchia AM, Consiglio A Pesole G, Sbisà E, Inzaghi E, Cianfarani S, Tullo A. Pilot study on circulating miRNA signature in children with obesity born small for gestational age and appropriate for gestational age. Pediatric Obesity Dec;13(12):803-811. 2018 168 Inzaghi E, Reiter E, Cianfarani S. The Challenge of Defining and Investigating the Causes of Idiopathic Short Stature and Finding an Effective Therapy. Hormone Research in Paediatrics, 92(2):71-83, 2019 169 Binder G, Reinehr T, Ibáñez L, Thiele S, Linglart A, Woelfle J, Saenger P, Bettendorf M, Zachurzok A, Gohlke B, Randell T, Hauffa BP, Claahsen van der Grinten HL, Holterhus PM, Juul A, Pfäffle R, Cianfarani S. GHD Diagnostics in Europe and the US: An Audit of National Guidelines and Practice. Hormone Research in Paediatrics, 92(2):71-83, 2019 170 Cianfarani S Pediatric endocrinology in the time of COVID-19 pandemic Hormone Research in Paediatrics 92(6):345-346, 2019 171 Pampanini V, Jahnukainen K, Sahlin L, Germani D, Puglianiello A, Cianfarani S, Söder O Impact of uteroplacental insufficiency on ovarian follicular pool in the rat. Reproductive Biology and Endocrinology, Jan 10;17(1):10, 2019 172 Swerdlow AJ, Cooke R, Beckers D, Butler G, Carel JC, Cianfarani S, Clayton P, Coste J, Deodati A, Ecosse E, Hokken-Koelega ACS, Khan AJ, Kiess W, Kuehni CE, Flück CE, Pfaffle R, Sävendahl L, Sommer G, Thomas M, Tidblad A, Tollerfield S, Zandwijken GRJ. Risk of Meningioma in European Patients Treated with Growth Hormone in Childhood: Results from the SAGhE Cohort. Journal of Clinical Endocrinology and Metabolism, Mar 1;104(3):658-664, 2019. 173 Spreghini N, Cianfarani S, Spreghini MR, Brufani C, Morino GS, Inzaghi E, Convertino A, Fintini D, Manco M. Oral glucose effectiveness and metabolic risk in obese children and adolescents Acta Diabetologica, Aug;56(8):955-962, 2019 174 Centonze C, Guzzetti C, Orlando G, Loche S; Italian ECOS Investigators. Adherence to growth hormone (GH) therapy in naïve to treatment GH-deficient children: data of the Italian Cohort from the Easypod Connect Observational Study (ECOS) Journal of Endocrinological Investigation, Oct;42(10):1241-1244, 2019. 175 Bizzarri C, Pedicelli S, Romanzo A, Bocchini S, Bottaro G, Cianfarani S, Cappa M. The impact of IGF-I, puberty and obesity on early retinopathy in children: a cross-sectional study. Italian Journal of Pediatrics Apr 27;45(1):52, 2019. 176 Cianfarani S Risk of cancer in patients treated with recombinant human growth hormone in childhood. Annals of Pediatric Endocrinology and Metabolism, Jun;24(2):92-98, 2019 177 Nobili V, Mantovani A, Cianfarani S, Alisi A, Mosca A, Sartorelli MR, Maffeis C, Loomba R, Byrne CD, Targher G. Prevalence of prediabetes and diabetes in children and adolescents with biopsy-proven non-alcoholic fatty liver disease. Journal of Hepatology, Oct;71(4):802-810, 2019. 178 Inzaghi E, Kistner A, Germani D, Deodati A, Vanpee M, Legnevall L, Berinder K, Cianfarani S. A prospective case-control study on miRNA circulating levels in subjects born small for gestational age (SGA) evaluated from childhood into young adulthood. PloS One, Jan 24;15(1):e0228075, 2020 179 Deodati A, Inzaghi E, Cianfarani S. Epigenetics and In Utero Acquired Predisposition to Metabolic Disease. Frontiers in Genetics, Jan 29;10:127, 2020. 180 Tassinari R, Narciso L, Tait S, Busani L, Martinelli A, Di Virgilio A, Carli F, Deodati A, La Rocca C, Maranghi F; LIFE PERSUADED Project Group. Juvenile Toxicity Rodent Model to Study Toxicological Effects of Bisphenol A (BPA) at Dose Levels Derived from Italian Children Biomonitoring Study. Toxicological Sciences, Feb 1;173(2):387-401, 2020 181 Tait S, Carli F, Busani L, Buzzigoli E, Della Latta V, Deodati A, Fabbrizi E, Gaggini M, Maranghi F, Tassinari R, Toffol G, Cianfarani S, Gastaldelli A, La Rocca C; LIFE PERSUADED Project Group. Biomonitoring of Bis(2-ethylhexyl)phthalate (DEHP) in Italian children and adolescents: Data from LIFE PERSUADED project. Environmental Research, Jun;185:109428, 2020 182 Fintini D, Cianfarani S, Cofini M, Andreoletti A, Ubertini GM, Cappa M, Manco M. The bones of children with obesity. Frontiers in Endocrinology, Apr 24;11:200, 2020. 183 Schiaffini R, Barbetti F, Rapini N, Inzaghi E, Deodati A, Patera IP, Matteoli MC, Ciampalini P, Carducci C, Lorubbio A, Schiaffini G, Cianfarani S. School and pre-school children with type 1 diabetes during Covid-19 quarantine: The synergic effect of parental care and technology. Diabetes Research in Clinical Practice, Aug;166:108302, 2020. 184 Sävendahl L, Cooke R, Tidblad A, Beckers D, Butler G, Cianfarani S, Clayton P, Coste J, Hokken-Koelega ACS, Kiess W, Kuehni CE, Albertsson-Wikland K, Deodati A, Ecosse E, Gausche R, Giacomozzi C, Konrad D, Landier F, Pfaeffle R, Sommer G, Thomas M, Tollerfield S, Zandwijken GRJ, Carel JC, Swerdlow AJ. Long-term mortality after childhood growth hormone treatment: the SAGhE cohort study. Lancet diabetes and Endocrinology, Aug;8(8):683-692, 2020 185 Amodeo ME, Inzaghi E, Deodati A, Cianfarani S. Endocrinological features of a patient with 14q microdeletion and Dubowitz phenotype. Mol Genet Genomic Med.May 31;e1644. doi: 10.1002/mgg3.16, 2021. 186 Petrelli A, Ravà L, Mascali A, Rapini N, Massoud M, Manca Bitti ML, Cianfarani S, Manco M. Estimated insulin sensitivity, cardiovascular risk, and hepatic steatosis after 12 years from the onset of T1D Diabetes Metab Res Rev. Jun 2:e3479, 2021. 187 Inzaghi E, Deodati A, Loddo S, Mucciolo M, Verdecchia F, Sallicandro E, Catino G, Cappa M, Novelli A, Cianfarani S. Prevalence of copy number variants (CNVs) and rhGH treatment efficacy in an Italian cohort of children born small for gestational age (SGA) with persistent short stature associated with a complex clinical phenotype J Endocrinol Invest. Jan;45(1):79-87, 2022 188 Cianfarani S, Pampanini V The Impact of Stress on Health in Childhood and Adolescence in the Era of the COVID-19 Pandemic Horm Res Paediatr. Jul 14:345-349, 2021 189 Giglione E, Lapolla R, Cianfarani S, Faienza MF, Fintini D, Weber G, Delvecchio M, Valerio G. Linear growth and puberty in childhood obesity: what is new? Minerva Pediatr (Torino). Dec;73(6):563-571, 2021. 190 Carducci C, Rapini N, Deodati A, Pampanini V, Cianfarani S, Schiaffini R. Post-traumatic stress disorder (PTSD) in parents of children with type 1 diabetes during Covid-19 pandemic. Ital J Pediatr. Aug 26;47(1):176, 2021. 191 Tait S, Carli F, Busani L, Ciociaro D, Della Latta V, Deodati A, Fabbrizi E, Pala AP, Maranghi F, Tassinari R, Toffol G, Cianfarani S, Gastaldelli A, La Rocca C, Life Persuaded Project Group. Italian Children Exposure to Bisphenol A: Biomonitoring Data from the LIFE PERSUADED Project. Int J Environ Res Public Health. Nov 12;18(22):11846, 2021. 192 Stefano Cianfarani. Safety of Pediatric rhGH Therapy: An Overview and the Need for Long-Term Surveillance Frontiers in Endocrinology, Dec 24;12:811846, 2021. 193 Zucchini S, Di Iorgi N, Pozzobon G, Pedicelli S, Parpagnoli M, Driul D, Matarazzo P, Baronio F, Crocco M, Giudica G, Partenope C, Nardini B, Ubertini G, Menardi R, Guzzetti C, Iughetti L, Aversa T, Di Mase R, Cassio A, Cianfarani S, Maghnie M, Tuli G, Loche S, Bruzzi P, Wasniewska M, Salerno M, Rutigliano I, Iezzi ML, Cherubini V, Grandone A, Faienza M, Tumini S, Baldoli C, Consales A, Genitori L, Marras CE, MIlanaccio C, Mortini P, Vindigni M, Zenga F, Zucchelli M; Physiopathology of Growth Processes; Puberty Study Group of the Italian Society for Pediatric Endocrinology and Diabetology. Management of Childhood-onset Craniopharyngioma in Italy: A Multicenter, 7-Year Follow-up Study of 145 Patients J Clin Endocrinol Metab. Feb 17;107(3):e1020-e1031, 2022. 194 Stefania Pedicelli, Danilo Fintini, Lucilla Ravà, Elena Inzaghi, Annalisa Deodati, Maria Rita Spreghini, Carla Bizzarri, Michela Mariani, Stefano Cianfarani, Marco Cappa, Melania Manco, Prevalence of prediabetes in children and adolescents by class of obesity. Pediatr Obes. Feb 10;e12900, 2022 195 Giorgia Sforza, Annalisa Deodati, Romina Moavero, Laura Papetti, Ilaria Frattale,Federico Vigevano, Stefano Cianfarani, Massimiliano Valeriani. Benign Intracranial Hypertension Due to Hypoparathyroidism: A Case Report. Frontiers in Neurology, Jan 10;12:818638, 2022 196 Arianna Petrelli, Lucilla Ravà, Alberto Mascali, Novella Rapini, Michela Massoud, Maria Luisa Manca Bitti, Stefano Cianfarani, Melania Manco. Estimated insulin sensitivity, cardiovascular risk, and hepatic steatosis after 12 years from the onset of T1D. Diabetes Metab Res Rev., Jan;38(1):e3479, 2022 197 Conor McClenaghan, Novella Rapini, Domenico Umberto De Rose, Jian Gao, Jacob Roeglin, Carla Bizzarri, Riccardo Schiaffini, Eloisa Tiberi, Mafalda Mucciolo, Annalisa Deodati, Alessandro Perri, Giovanni Vento, Fabrizio Barbetti, Colin G Nichols, Stefano Cianfarani. Sulfonylurea-insensitive permanent neonatal diabetes caused by a severe gain-of-function Tyr330His substitution in Kir6.2. Horm Res Paediatr. Jan 7. doi: 10.1159/000521858, 2022. 198 Annalisa Deodati, Elena Inzaghi, Daniela Germani, Francesca Fausti, Stefano Cianfarani. Crk Haploinsufficiency Is Associated with Intrauterine Growth Retardation and Severe Postnatal Growth Failure. Horm Res Paediatr, Jan 27;1-11. doi: 10.1159/000521629, 2022 199 Schiaffini R, Deodati A, Nicoletti MC, Carducci C, Ciampalini P, Lorubbio A, Matteoli MC, Pampanini V, Patera IP, Rapini N, Cianfarani S. Comparison of two advanced hybrid closed loop in a pediatric population with type 1 diabetes: a real-life observational study. Acta Diabetologica 59:959-964, 2022 200 Inzaghi E, Pampanini V, Deodati A and Cianfarani S The effects of nutrition on linear growth Nutrients 14(9):1752, 2022 201 Boguszewski MCS, Boguszewski CL, Chemaitilly W, Cohen LE, Gebauer J, Higham C, Hoffman AR, Polak M, Yuen KCJ, Alos N, Antal Z, Bidlingmaier M, Biller BMK, Brabant G, Choong CSY, Cianfarani S, Clayton PE, Coutant R, Cardoso-Demartini AA, Fernandez A, Grimberg A, Guðmundsson K, Guevara-Aguirre J, Ho KKY, Horikawa R, Isidori AM, Jørgensen JOL, Kamenicky P, Karavitaki N, Kopchick JJ, Lodish M, Luo X, McCormack AI, Meacham L, Melmed S, Mostoufi Moab S, Müller HL, Neggers SJCMM, Aguiar Oliveira MH, Ozono K, Pennisi PA, Popovic V, Radovick S, Savendahl L Touraine P, van Santen HM, Johannsson G. Safety of growth hormone replacement in survivors of cancer and intracranial and pituitary tumours: a consensus statement. European Journal of Endocrinology, 186(6):P35-P52, 2022 202 Pampanini V, Deodati A, Inzaghi E, Cianfarani S. Long-acting growth hormone preparations and their use in children with growth hormone deficiency. Hormone Research in Paediatrics Feb 25. doi: 10.1159/000523791, 2022 203 Barbetti F, Rapini N, Schiaffini R, Bizzarri C, Cianfarani S. The application of precision medicine in monogenic diabetes. Expert Rev Endocrinol Metab. Mar;17(2):111-129, 2022 204 Dunger DB, Bruggraber SFA, Mander AP, Marcovecchio ML, Tree T, Chmura PJ, Knip M, Schulte AM, Mathieu C; INNODIA consortium. INNODIA Master Protocol for the evaluation of investigational medicinal products in children, adolescents and adults with newly diagnosed type 1 diabetes Trials. 2022 May 18;23(1):414. doi: 10.1186/s13063-022-06259-z. 205 Novella Rapini, Patrizia I. Patera, Riccardo Schiaffini, Paolo Ciampalini, Valentina Pampanini, Matteoli M. Cristina, Annalisa Deodati, Giorgia Bracaglia, Ottavia Porzio, Rosario Ruta, Antonio Novelli, Mafalda Mucciolo, Stefano Cianfarani, Fabrizio Barbetti. Monogenic diabetes clinic (MDC): 3‐year experience Acta Diabetologica Sep 30. doi: 10.1007/s 00592-022-01972-2, 2022 206 Del Chierico F, Conta G, Matteoli MC, Fierabracci A, Reddel S, Macari G, Gardini S, Guarrasi V, Levi Mortera S, Marzano V, Vernocchi P, Sciubba F, Marini F, Deodati A, Rapini N, Cianfarani S, Miccheli A, Putignani L Gut Microbiota Functional Traits, Blood pH, and Anti-GAD Antibodies Concur in the Clinical Characterization of T1D at Onset. Int J Mol Sci. Sep 6;23(18):10256, 2022 207 Carli F, Tait S, Busani L, Ciociaro D, Della Latta V, Pala AP, Deodati A, Raffaelli A, Pratesi F, Conte R, Maranghi F, Tassinari R, Fabbrizi E, Toffol G, Cianfarani S, La Rocca C, Gastaldelli A, Life Persuaded Project Group. Exposure to Endocrine Disruptors (Di(2-Ethylhexyl)phthalate (DEHP) and Bisphenol A (BPA)) in Women from Different Residing Areas in Italy: Data from the LIFE PERSUADED Project. Int J Mol Sci. Dec 16;23(24):16012. 2022 208 Levi Mortera S, Marzano V, Vernocchi P, Matteoli MC, Guarrasi V, Gardini S, Del Chierico F, Rapini N, Deodati A, Fierabracci A, Cianfarani S, Putignani L Functional and Taxonomic Traits of the Gut Microbiota in Type 1 Diabetes Children at the Onset: A Metaproteomic Study. Int J Mol Sci. 2022 Dec 15;23(24):15982. 2022 209 Del Chierico F, Rapini N, Deodati A, Matteoli MC, Cianfarani S, Putignani L. Pathophysiology of Type 1 Diabetes and Gut Microbiota Role Int J Mol Sci. Nov 24;23(23):14650. 2022 210 Anita C. S. Hokken-Koelega, Manouk van der Steen, Margaret C. S. Boguszewski, Stefano Cianfarani, Jovanna Dahlgren, Reiko Horikawa, et al. International Consensus Guideline on Small for Gestational Age: Etiology and Management From Infancy to Early Adulthood. Endocrine Reviews, 2023, 00, 1–27 https://doi.org/10.1210/endrev/bnad002 211 Pezzino G, Ruta R, Rapini N, Chiodo DC, Mucciolo M, Tomaselli L, Cianfarani S, Barbetti F. A rare cause of transient neonatal diabetes mellitus: Spontaneous HNF1B splice variant. Diabet Med. 2024 Feb;41(2):e15202. doi: 10.1111/dme.15202. 212 Mosca A, Manco M, Braghini MR, Cianfarani S, Maggiore G, Alisi A, Vania A. Environment, Endocrine Disruptors, and Fatty Liver Disease Associated with Metabolic Dysfunction (MASLD). Metabolites. 2024 Jan 22;14(1):71. doi: 10.3390/metabo14010071. 213 Ravà L, Fintini D, Mariani M, Deodati A, Inzaghi E, Pedicelli S, Bizzarri C, Cappa M, Cianfarani S, Manco M. High 1-h glucose in youths with obesity as marker of prediabetes and cardiovascular risk. J Endocrinol Invest. 2023 Dec;46(12):2555-2562. doi: 10.1007/s40618-023-02111-6. 214 Aureli A, Recupero R, Mariani M, Manco M, Carlomagno F, Bocchini S, Nicodemo M, Marchili MR, Cianfarani S, Cappa M, Fintini D. Low Levels of Serum Total Vitamin B12 Are Associated with Worse Metabolic Phenotype in a Large Population of Children, Adolescents and Young Adults, from Underweight to Severe Obesity. Int J Mol Sci. 2023 Nov 22;24(23):16588. doi: 10.3390/ijms242316588 215 Deodati A, Bottaro G, Germani D, Carli F, Tait S, Busani L, Della Latta V, Pala AP, Maranghi F, Tassinari R, Gastaldelli A, La Rocca C, Cianfarani S. Urinary Bisphenol-A (BPA) and Bis(2-ethylhexyl)phthalate (DEHP) metabolite concentrations in children with obesity: A case-control study. LIFE PERSUADED Project Group. Horm Res Paediatr. 2023 Nov 16. doi: 10.1159/000535305. 216 Franceschi R, Fintini D, Ravà L, Mariani M, Aureli A, Inzaghi E, Pedicelli S, Deodati A, Bizzarri C, Cappa M, Cianfarani S, Manco M. Insulin Clearance at the Pubertal Transition in Youth with Obesity and Steatosis Liver Disease. Int J Mol Sci. 2023 Oct 6;24(19):14963. doi: 10.3390/ijms241914963. 217 Amodio D, Pascucci GR, Cotugno N, Rossetti C, Manno EC, Pighi C, Morrocchi E, D'Alessandro A, Perrone MA, Valentini A, Franceschini A, Chinali M, Deodati A, Azzari C, Rossi P, Cianfarani S, Andreani M, Porzio O, Palma P. Similarities and differences between myocarditis following COVID-19 mRNA vaccine and multiple inflammatory syndrome with cardiac involvement in children. Clin Immunol. 2023 Oct;255:109751. doi: 10.1016/j.clim.2023.109751 218 Troncone A, Affuso G, Cascella C, Chianese A, Zanfardino A, Iafusco D; Diabetes Study Group of Italian Society of Paediatric Endocrinology and Diabetology. Prevalence and Multidimensional Model of Disordered Eating in Youths With Type 1 Diabetes: Results From a Nationwide Population-Based Study. J Pediatr Psychol. 2023 Sep 20;48(9):731-739. doi: 10.1093/jpepsy/jsad016 219 Suomi T, Starskaia I, Kalim UU, Rasool O, Jaakkola MK, Grönroos T, Välikangas T, Brorsson C, Mazzoni G, Bruggraber S, Overbergh L, Dunger D, Peakman M, Chmura P, Brunak S, Schulte AM, Mathieu C, Knip M, Lahesmaa R, Elo LL; INNODIA Consortium. Gene expression signature predicts rate of type 1 diabetes progression. EBioMedicine. 2023 Jun;92:104625. doi: 10.1016/j.ebiom.2023.104625 220 Cianfarani S, Battelino T. A critical review of upcoming new therapeutic options in paediatric endocrinology. Horm Res Paediatr. 2023 Apr 24. doi: 10.1159/000530824. 221 Rapini N, Delvecchio M, Mucciolo M, Ruta R, Rabbone I, Cherubini V, Zucchini S, Cianfarani S, Prandi E, Schiaffini R, Bizzarri C, Piccini B, Maltoni G, Predieri B, Minuto N, Di Paola R, Giordano M, Tinto N, Grasso V, Russo L, Tiberi V, Scaramuzza A, Frontino G, Maggio MC, Musolino G, Piccinno E, Tinti D, Carrera P, Mozzillo E, Cappa M, Iafusco D, Bonfanti R, Novelli A, Barbetti F; Diabetes Study Group of Italian Society for Pediatric Endocrinology and Diabetes (ISPED). The changing landscape of neonatal diabetes mellitus in Italy between 2003-2022. J Clin Endocrinol Metab Feb 26:dgae095. doi: 10.1210/clinem/dgae095, 2024. 222 Hendriks AEJ, Marcovecchio ML, Besser REJ, Bonifacio E, Casteels K, Elding Larsson H, Gemulla G, Lundgren M, Kordonouri O, Mallone R, Pociot F, Szypowska A, Toppari J, Berge TVD, Ziegler AG, Mathieu C, Achenbach P; INNODIA consortium, the Fr1da Study Group and the GPPAD Study Group. Clinical care advice for monitoring of islet autoantibody positive individuals with presymptomatic type 1 diabetes. Diabetes Metab Res Rev. Feb;40(2):e3777. doi: 10.1002/dmrr.3777, 2024. 223 Rapini N, Martino M, Arnaldi C, Deodati A, Anagnostopoulou L, Amodeo ME, Ciampalini P, Pampanini V, Lorubbio A, Tosini D, Cianfarani S, Schiaffini R. Efficacy and safety of advanced hybrid closed loop systems in children with type 1 diabetes younger than 6 years. Front Endocrinol (Lausanne). May 21:15:1382920, 2024 224 Schiaffini R, Lumaca A, Martino M, Rapini N, Deodati A, Amodeo ME, Ciampalini P, Matteoli MC, Pampanini V, Cianfarani S. Time In Tight Range in children and adolescents with type 1 diabetes: A cross-sectional observational single centre study evaluating efficacy of new advanced technologies. Diabetes Metab Res Rev. Jul;40(5):e3826. 2024. Letters 1. Cianfarani S., Spadoni G.L., Manca Bitti M.L., Boscherini B. Growth hormone treatment and somatomedin C levels. Journal of Pediatrics 105, 853, 1984. 2. Scirè G., Cianfarani S., Spadoni G.L., Manca Bitti M.L., Fonte M.T., Boscherini B., Pasquino A.M., Bozzao L. Primary empty sella and endocrinopathies in childhood: high prevalence among children with precocious puberty. European Journal of Pediatrics 147, 665, 1988. 3. Spadoni GL, Cianfarani S, Bernardini S, Vaccaro F, Galasso C, Boscherini B. How far should indications for growth hormone expand? Lancet 335, 1351, 1990. 4. Scirè G, Magliocca FM, Cianfarani S, Scalamandrè A, Petrozza Bonamico M. Autoimmune polyendocrine candidiasis syndrome with associated chronic diarrhea caused by intestinal infection and pancreas insufficiency. Journal of Pediatric Gastroenterology and Nutrition 13, 224-227, 1991. 5. Cianfarani S. Growth hormone therapy in Noonan syndrome. Journal of Pediatrics 134, 385-6, 1999. 6. Cianfarani S. Ambras syndrome or hypertrichosis universalis, does it really matter? Clinical Genetics 57, 158, 2000. 7. Cianfarani S, Bonfanti R, Manca Bitti ML, Chiumello G, Boscherini B. Growth and autoantibodies to IA-2 in children with type 1 diabetes. Lancet 356, 1521, 2000. 8. Cianfarani S. Role of Hormones in Puberty Lancet 358, 1459, 2001. 9. Schiaffini R, Deodati A, Rapini N, Pampanini V, Cianfarani S. Increased incidence of childhood type 1 diabetes during the COVID-19 pandemic. Figures from an Italian tertiary care center. Journal of Diabetes. 2022 Aug;14(8):562-563. Testi e Monografie Boscherini B., Cianfarani S., Spadoni G.L., Mancuso G. Il bambino con bassa statura. Ed: Piccin, Padova, 1990. Cianfarani S. Bambini Nati Piccoli per Età Gestazionale (small for gestational age, SGA): Implicazioni Cliniche. Come, Quando e Perchè Trattarli con l’Ormone della Crescita. Ed: Mediprint, Roma, 2007. Capitoli di testi C1 Boscherini B., Spadoni G.L., Cianfarani S. Le anomalie della crescita: eziologia e classificazione. In: Progressi nella Diagnosi e Terapia dei Disturbi dell'Accrescimento. A cura di E.E. Muller & G. Chiumello. Pythagora Press, Milano, pp. 175-197, 1987. C2 Cianfarani S, Spadoni GL. La bassa statura (Short Stature). In: Endocrinologia Pediatrica (Paediatric Endocrinology). Boscherini B. & Scalamandre' A. Ed. Nuova Scientifica Italiana, Roma, pp. 13-47, 1991. C3 Cianfarani S. Gli ormoni: Azione degli ormoni e loro dosaggio. In: Diagnosi e Terapia in Endocrinologia. GL Spadoni, AP Taviani, V Toscano. Ed. Grasso, Bologna, 1993, pp.1-15. C4 Cianfarani S. Disturbi della Crescita (Growth Disorders). In: Dal Sintomo alla Diagnosi in Endocrinologia Pediatrica (From Symptoms to Diagnosis in Pediatric Endocrinology). B. Boscherini, GL Spadoni, S. Stoduto. Carocci Editore, Roma, 2003. C5 Cianfarani S. Tumori Associati ad Endocrinopatie (Tumors associated to Endocrinopaties). In: Dal Sintomo alla Diagnosi in Endocrinologia Pediatrica (From Symptoms to Diagnosis in Pediatric Endocrinology). B. Boscherini, GL Spadoni, S. Stoduto. Carocci Editore, Roma, 2003. C6 Giacomozzi C and Cianfarani S. Patologie dell’ipofisi anteriore. Deficit di GH. “Hypopituitarism: GH deficiency”. Capitolo 73, pp. 659-669. Vademecum di Diagnosi e Terapia Pediatrica, Margiacchi-Galeno Editrice, Perugia 2008. C7 Giacomozzi C and Cianfarani S. Diabete insipido e sindrome da inappropriata secrezione di ormone antidiurerico “Diabetes insipidus and sindrome of inappropriate antidiuretic hormone (SIADH)”. Capitolo 74, pp. 669-679. Vademecum di Diagnosi e Terapia Pediatrica, Margiacchi-Galeno Editrice, Perugia 2008. C8 Cianfarani S. Neuroendocrine Complications of Central Nervous System Malformations. Chapter 23. In: Maformations of the Nervous System, Handbook of Clinical neurology, 3rd Edition. Eds: H.B. Sarnat, P. Curatolo. Elsevier Ltd., pp 433- 458, 2008. C9 Cianfarani S. Growth and growth factors. In: Yearbok of Pediatric Endocrinology. Eds: Carel JC and Hochberg. Z. Karger AG, Basel, Switzerland, 2010, pp 49-64. C10 Pedicelli S, Scirè G, Bertelloni S, Peschiaroli E, Deodati A, Garofalo P e Cianfarani S. Il deficit di ormone della crescita nel periodo di transizione. Adolescentologia Aspetti Medici e Socio-Educativi, cap. 6, pp 57-62, 2010 C11 Cianfarani S. Growth and growth factors. In: Yearbok of Pediatric Endocrinology. Eds: Carel JC and Hochberg. Z. Karger AG, Basel, Switzerland, 2011, pp 47-61. C12 Cianfarani S. Growth and growth factors. In: Yearbook of Pediatric Endocrinology. Eds: Ong K and Hochberg. Z. Karger AG, Basel, Switzerland, 2012, p. 45-59. C13 Cianfarani S. Growth and growth factors. In: Yearbook of Pediatric Endocrinology. Eds: Ong K and Hochberg. Z. Karger AG, Basel, Switzerland, 2013, P. 45-60. C14 Inzaghi E and Cianfarani S. Growth and growth factors. In: Yearbook of Pediatric Endocrinology. Eds: Ong K and Hochberg. Z. Karger AG, Basel, Switzerland, 2014, P. 45-61. C15 Inzaghi E and Cianfarani S. Growth and growth factors. In: Yearbook of Pediatric Endocrinology. Eds: Ong K and Hochberg. Z. Karger AG Haymarket, Teddington, UK, 2015, P. 40-59 C16 Inzaghi E and Cianfarani S. Growth and growth factors. In: Yearbook of Pediatric Endocrinology. Eds: Ong K and Hochberg. Z. Haymarket, Teddington, UK, 2016, P. 49-64. C17 Inzaghi E and Cianfarani S. Growth and growth factors. In: Yearbook of Pediatric Endocrinology. Eds: Ong K and Hochberg. Z. Haymarket, Teddington, UK, 2017, P. 50-67. ATTIVITA' EDITORIALE Boscherini B., Cianfarani S., Spadoni G.L. Eds. Binding proteins for growth hormone and somatomedins. Acta Endocrinologica, Vol. 124, Supplement 2, 1991. Cianfarani S, Clemmons DR, Savage MO (eds.). IGF-I and IGF binding proteins. Basic research and clinical management. Endocrine Development, Basel, Karger, Vol.9, 2005 Stefano Cianfarani, Yves Le Bouc, Martin Savage (eds.). The evolving biology of growth and metabolism. European Journal of Endocrinology 157: Supplement 1, 2007. Cappa M, Cianfarani S, Ghizzoni L, Loche S, Maghnie M (eds.) Advanced therapies in pediatric Endcorinology and Diabetology. Endocrine Development, Basel, Karger, Vol.30, 2015. Cianfarani S and Soder O (eds.) Emdocrine disruptors and child health. Hormone Research in Paediatrics, Karger, basel, Vol. 86 (4), 215-290, 2016.management. Endocrine Development, Basel, Karger, Vol.9, 2005
Stefano Cianfarani, Yves Le Bouc, Martin Savage (eds.). The evolving biology of growth and metabolism. European Journal of Endocrinology 157: Supplement 1, 2007.
Cappa M, Cianfarani S, Ghizzoni L, Loche S, Maghnie M (eds.) Advanced therapies in pediatric Endcorinology and Diabetology. Endocrine Development, Basel, Karger, Vol.30, 2015.
Cianfarani S and Soder O (eds.) Emdocrine disruptors and child health. Hormone Research in Paediatrics, Karger, basel, Vol. 86 (4), 215-290, 2016.
| Nome del Corso | Facoltà | Anno | ||
|---|---|---|---|---|
| 0 | Pediatric Sciences | Medicina E Chirurgia | 2019/2020 | |
| Modulo: General And Specialised Pediatrics | Medicina E Chirurgia | 2019/2020 | ||
| 0 | Pediatric Sciences | Medicina E Chirurgia | 2018/2019 | |
| Modulo: General And Specialised Pediatrics | Medicina E Chirurgia | 2018/2019 |