Eleonora Candi

CV BREVE

POSIZIONE ATTUALE: (i) Professore Ordinario in Biologia Molecolare presso il Dipartimento di Medicina Sperimentale e Chirurgia, Università di Roma “Tor Vergata”, Roma, Italia. (ii) PI laboratorio di Biochimica,  IDI-IRCCS, Roma.

TITOLO di STUDIO:      Dottorato di Ricerca (1995, Roma) in “Biologia degli Epiteli, Laurea (1991, Roma) in Biologia.

POSIZIONI PRECEDENTI: Post-Dottorato presso “Skin Biology Branch”, NIAMS-NIH, Bethesda MD, USA (laboratorio diretto dal Dr. P.M. Steinert) dal 1993-1997.  Rientro a Roma con “Rientro dei Cervelli” finanziato da Telethon (fino al 2001). Ricercatore in Biologia Molecolare (BIO/11) presso il Dipartimento di Medicina Sperimentale e Biochimica, Università di Roma “Tor Vergata” (fino al 2012). Associato in Biologia Molecolare (BIO/11) presso il Dipartimento di Medicina Sperimentale e Chirurgia, Università di Roma “Tor Vergata” (fino al 2017).

ATTIVITA’ EDITORIALE: Editor-in-chief di Discover Oncology (Springer-Nature). Membro dell’ “Editorial Board” di: (i) The FEBS Journal; (ii) Encyclopedia of Life Science, Wiley-Blackwell; (iii) Molecular Cellular Oncology, Landes Biosciences; (iv) Cell Death Disease (www.nature.com.cddis).

INTERESSI SCIENTIFICI: Biochimica dell’epidermide, Transglutaminasi, Involucro corneo, Famiglia genica di p53, p63, micro-RNA, lncRNA, regolazione trascrizionale generazione e caratterizzazione di topi transgenici. 

PUBBLICAZIONI: 158 articoli scientifici; H-index = 53. Cites = 21971 (Google Scholar). Cumulative IF:779

SELECTED ARTICLE (10):

1. Lena et al. The p63 C-terminus is essential for murine oocytes integrity. NatureComms. 2021; 12:383. [IF: 12.121]

2. Panatta E et al. Long non-coding RNA uc.291 controls epithelial differentiation by interfering with the ACTL6A/BAF complex. EMBO Rep. 2020. 21(3):e46734.                                                            [IF: 7.497]

3. Viticchiè G, et al. p63 supports aerobic respiration through hexokinase II.

Proc Natl Acad Sci U S A. 2015. 112(37):11577-82.                                                                  [IF: 9.771]

4. Amelio I, et al. miR-24 triggers epidermal differentiation by controlling actin adhesion and cell migration.  

J Cell Biology. 2012;199(2):347-63.                                                                              [IF: 10.264]

5. Rivetti di Val Cervo P, et al. p63-microRNA feedback in keratinocyte senescence.

Proc Natl Acad Sci U S A. 2012. 109(4):1133-8.                                                                        [IF: 9.771]

6. Agostini M, et al. Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets. Proc Natl Acad Sci U S A. 2011. 108(52):21093-8.                                              [IF: 9.771]

7. Notari M, et al. Inhibitor of apoptosis-stimulating protein of p53 (iASPP) prevents senescence and is required for epithelial stratification.  Proc Natl Acad Sci U S A. 2011. 108(40):16645-50.    [IF: 9.771]

8. Boase NA, et al. Respiratory distress and perinatal lethality in Nedd4-2-deficient mice.

Nature Commun. 2011; 2:287.                                                                                      [IF: 12.764]

9. Gonfloni S, et al. Inhibition of the c-Abl-TAp63 pathway protects mouse oocytes from chemotherapy-induced death. Nature Medicine. 2009.15(10):1179-85.                                                            [IF: 27.553]

10. Candi E, et al. DeltaNp63 regulates thymic development through enhanced expression of FgfR2 and Jag2.  Proc Natl Acad Sci U S A. 2007.104(29):11999-2004.                                                    [IF=9.643]

REVIEWS (4):

1. Amelio I et al. Emerging roles of long non-coding RNAs in breast cancer biology and management. Semin Cancer Biol. 2020. S1044-579X(20)30155-3.

2. Dötsch V, et al.  p63 and p73, the ancestors of p53. Cold Spring Harb Perspect Biol. 2010 Sep;2(9):a004887.

3. Aberdam D, et al.   miRNAs, 'stemness' and skin. Trends Biochem Sci. 2008. 33(12):583-91.

4. Candi E, et al.  The cornified envelope: a model of cell death. Nature Reviews Molec. Cell. Biol. 2005. 6:328-40.